AUTHOR=Roberts Blaine R., Lothian Amber , Hare Dominic J., Masters Colin L., Ryan Timothy M., Grimm Rudolf 

TITLE=Metalloproteomics: principles, challenges and applications to neurodegeneration

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=5

YEAR=2013

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2013.00035

DOI=10.3389/fnagi.2013.00035

ISSN=1663-4365

ABSTRACT=<p>Trace elements are required for a variety of normal biological functions. As our understanding of neurodegenerative disease advances we are identifying a number of metalloenzymes involved in disease process. Thus, the future of metals in neurobiology will rely more on detailed information regarding what metalloenzymes are present and how they are involved in the pathophysiology of disease. To gain this detailed information, we will rely less on bulk measures of the amount of a trace elements in a particular tissue and turn to metalloproteomic techniques to help elucidate both metalloprotein structure <italic>and</italic> function. Recent advances in metalloproteomics will translate to a richer understanding of the mechanism and precise role of metalloenzymes and proteins in the brain.</p>