AUTHOR=Kumar Ashok 

TITLE=Long-Term Potentiation at CA3–CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress

JOURNAL=Frontiers in Aging Neuroscience

VOLUME=3

YEAR=2011

URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2011.00007

DOI=10.3389/fnagi.2011.00007

ISSN=1663-4365

ABSTRACT=<p>Synaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmission following the delivery of a brief, high-frequency train of electrical stimulation. LTP is regarded as a principal candidate for the cellular mechanisms involved in learning and offers an attractive hypothesis of how memories are constructed. There are a number of exceptional full-length reviews published on LTP; the current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults.</p>