AUTHOR=Tampellini Davide , Gouras Gunnar K. TITLE=Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease JOURNAL=Frontiers in Aging Neuroscience VOLUME=2 YEAR=2010 URL=https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2010.00013 DOI=10.3389/fnagi.2010.00013 ISSN=1663-4365 ABSTRACT=

β-Amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer's disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons. Synapses are important targets of β-amyloid, and alterations in synapses better correlate with cognitive impairment than amyloid plaques or neurofibrillary tangles. The link between β-amyloid and synapses became even tighter when it was discovered that β-amyloid accumulates within synapses and that synaptic activity modulates β-amyloid secretion. Currently, a central question in Alzheimer's disease research is what role synaptic activity plays in the disease process, and how specifically β-amyloid is involved in the synaptic dysfunction that characterizes the disease.