Beyond PD-1: novel checkpoint receptors and ligands as targets for immunotherapy

Jesse Haramati, Dallas Flies, Fabiola Solorzano Ibarra

Frontiers Media SA

The incredible power of the immune system to control or eliminate neoplasias has been made evident...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: combined checkpoint therapies,­ICI,­engagers,­redirecting T cells,­biomarkers,­CAR,­Innate,­NK,­agonist,­Inflammation,­Phagocytosis

Deciphering the Regulatory Role of Transcription Factors in Cancer Immune Infiltration

Qian Yang, Yujia Lan, Jin-Fen Xiao

Frontiers Media SA

Transcription factors (TF) are proteins that bind to specific DNA sequences and regulate the...

Health Oncology Cancer Immunity and Immunotherapy

Keywords: Transcription Factors,­Epigenetic regulator,­Tumor Microenvironment,­cancer immunology,­Immune infiltration,­tumor immune escape,­regulatory networks

Tertiary lymphoid structures (TLS) in the tumor immune microenvironment

Ying Ma, Hui Zhao

Frontiers Media SA

Cancer has become the most common disease worldwide. With their extremely
aggressive nature of...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Tertiary lymphoid structures (TLSs),­Tumor microenvironment (TME),­Immunotherapy,­Immune checkpoint inhibitors (ICI),­Solid tumors (ST),­biomarkers,­prognosis

Novel Reliable Approaches for Prediction and Clinical Decision-making in Cancer

Ines Zidi, Safa Bhar Layeb, Vera Rebmann

Frontiers Media SA

Cancer is one of the leading causes of death worldwide. Significant advances in the understanding...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Cancer,­omics,­Systemic analysis,­cancer innovation,­artificial intelligence,­prediction,­decision-making,­data sciences.,­cancer immunology,­Immunotherapy,­Clinical data,­machine learning,­data science

Monoclonal Antibodies and Immune Checkpoint Inhibitors in the treatment of Cancer

Prakash Radhakrishnan, Cory L. Brooks, Murali M. Yallapu

Frontiers Media SA

Cancer is a complex disease that can evade the immune system's natural defenses. However, recent...

Health Oncology Cancer Immunity and Immunotherapy

Keywords: Antibodies,­Immunotherapy,­MABR,­immune checkpoint inhibitors

Spotlighting the Interaction Network of Hub Genes, Molecules, and Cells in the Tumor Immune Microenvironment (TIME) and their Contribution to Malignant Progression

Xuanbin Wang, Yongqian Shu, Xiaoqiang Qi, Run Shi

Frontiers Media SA

The tumor immune microenvironment (TIME) is a complex network of interactions between cancer cells,...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: tumor immune microenvironment (TIME),­interaction network,­Immune Activation and Evasion,­therapeutic targets,­precision medicine,­Translational research

Cell Death in Cancer Immunology

Laura Senovilla, Laura Mondragón Martínez, Shensi Shen

Frontiers Media SA

The relationship between cell death and cancer immunology has been addressed for decades with...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Cell Death,­Oncoimmunology,­Cancer,­immunology,­cancer immunotherapy

Application of Multi-omics Analysis in Thoracic Cancer Immunotherapy

Attila Szöllősi, Hailin Tang, Yuan Li, Jindong Xie

Frontiers Media SA

Based on statistical data provided by the World Health Organization, cancer is widely acknowledged...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: multi-omics,­Thoracic cancer,­Immunotherapy,­oncology,­Tumor Microenvironment

Cancer Immunotherapy – Diagnostic and Therapeutic Strategies to Enhance Antitumoral Efficacies whilst Minimizing Toxicity

Roza Nurieva, Sang T. Kim, Yeonseok Chung

Frontiers Media SA

With their unprecedented success, cancer immunotherapies including immune checkpoint inhibitors...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Immunotherapy,­Resistance to immunotherapy,­immune checkpoint inhibitors,­Immune-related adverse events