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GENERAL COMMENTARY article

Front. Surg., 29 September 2022
Sec. Visceral Surgery
Volume 9 - 2022 | https://doi.org/10.3389/fsurg.2022.1032084

Commentary: The impact of bariatric and metabolic surgery on cancer development

This article is a commentary on:

  1. The impact of bariatric and metabolic surgery on cancer development

    1. Read original article
\r\nMagdalena Taube Magdalena Taube1*Kajsa SjholmKajsa Sjöholm1Markku Peltonen,Markku Peltonen2,3Lena Carlsson\r\nLena Carlsson1
  • 1Department of Molecular and Clinical Medicine, Institute of Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
  • 2Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
  • 3Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden

A Commentary on
The impact of bariatric and metabolic surgery on cancer development
by Lunger F, Aeschbacher P, Nett PC, Peros G. Front Surg. (2022). 9:918272. doi: 10.3389/fsurg.2022.918272

Obesity is associated with increased cancer risk and bariatric surgery -leading to substantial, sustainable weight loss -has repeatedly been found to be associated with a reduced risk. To increase the understanding of this expanding research field review articles that summarize results from different studies are needed. One such review is the recent publication from Lunger et al. (1), in which pre- and post-interventional aspects of bariatric and metabolic surgery and its potential benefit on cancer development in patients with obesity is reviewed and discussed. We read this review with great interest, but as representatives of the Swedish Obese Subjects (SOS) study group we need to point out that the statement regarding our previously published report specifically analyzing incidence of colorectal cancer is incorrect (2).

In the review article by Lunger et al. it is stated that our study (2) demonstrates an increased risk of colorectal cancer with bariatric surgery and also that the risk increased steadily with time following surgery. In contrast, we found no evidence that colorectal cancer is affected by bariatric surgery (hazard ratiounadj with surgery = 0.79 (95% CI: 0.55–1.12; p = 0.183). In addition, when analyzing rectal cancer events separately- we found a decreased risk of rectal cancer with surgery (HRunadj = 0.56; 95% CI: 0.32–0.99; p = 0.045), while the risk of colon cancer was unchanged.

Author contributions

The authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors contributed to the article and approved the submitted version.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

1. Lunger F, Aeschbacher P, Nett PC, Peros G. The impact of bariatric and metabolic surgery on cancer development. Front Surg. (2022) 9:918272. doi: 10.3389/fsurg.2022.918272

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2. Taube M, Peltonen M, Sjöholm K, Palmqvist R, Andersson-Assarsson JC, Jacobson P, et al. Long-term incidence of colorectal cancer after bariatric surgery or usual care in the Swedish obese subjects study. PLoS One. (2021) 16:e0248550. doi: 10.1371/journal.pone.0248550

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Keywords: bariatric, surgery, cancer, colorectal, incidence

Citation: Taube M, Sjöholm K, Peltonen M and Carlsson L (2022) Commentary: The impact of bariatric and metabolic surgery on cancer development. Front. Surg. 9:1032084. doi: 10.3389/fsurg.2022.1032084

Received: 30 August 2022; Accepted: 13 September 2022;
Published: 29 September 2022.

Edited by:

Paolo Bernante, University of Bologna, Italy

Reviewed by:

Mirto Foletto, University Hospital of Padua, Italy

© 2022 Taube, Sjöholm, Peltonen and Carlsson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Magdalena Taube magdalena.taube@gu.se

Specialty Section: This article was submitted to Visceral Surgery, a section of the journal Frontiers in Surgery

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.