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MINI REVIEW article

Front. Public Health
Sec. Radiation and Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1517147
This article is part of the Research Topic Advances in Radiation Research and Applications: Biology, Environment and Medicine View all 4 articles

Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: An update on preclinical works

Provisionally accepted
Wangcai Ren Wangcai Ren 1Jialing Wen Jialing Wen 2Gang Guo Gang Guo 1,2Wenchao Gu Wenchao Gu 3Shenke Zhang Shenke Zhang 4Chang Liu Chang Liu 5,6Qiaojuan Wang Qiaojuan Wang 1,2Yue Wang Yue Wang 1,2Xuanzhang Tu Xuanzhang Tu 1Chen Li Chen Li 7*Li Sui Li Sui 2*Liqiu Ma Liqiu Ma 1,8,9*
  • 1 Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China
  • 2 National Innovation Center of Radiation Application, Beijing, China
  • 3 Department of Diagnostic and Interventional Radiology, University of Tsukuba, Ibaraki, Japan
  • 4 Shenzhen university medical school, Shenzhen, China
  • 5 National Institutes for Quantum Science and Technology, Chiba, Japan
  • 6 Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China
  • 7 China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National 15 Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China
  • 8 Gunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan
  • 9 National Institutes for Quantum and Radiological Science and Technology (Japan), Chiba, Japan

The final, formatted version of the article will be published soon.

    In the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal effect. Enhancing the incidence of this phenomenon possesses profound significance for the investigation of metastatic cancer treatment. Currently, the underlying mechanisms of the abscopal effect remain unclear. Radiation-induced immunogenic cell death is considered one of the potential mechanisms for the abscopal effect. From this perspective, we explored how physical parameters and biological factors influence this process. Differences between patients with respect to physical factors and intrinsic biological factors that activate the immune response (acquired factors) may affect the induction of the abscopal effect.

    Keywords: abscopal effect, physical parameters, Biological Factors, Radiotherapy, Immunogenic cell death

    Received: 25 Oct 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Ren, Wen, Guo, Gu, Zhang, Liu, Wang, Wang, Tu, Li, Sui and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chen Li, China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National 15 Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China
    Li Sui, National Innovation Center of Radiation Application, Beijing, China
    Liqiu Ma, Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.