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ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1475330
This article is part of the Research Topic Diagnosing and Treating Frailty and Sarcopenia in Middle-aged and Older Adults View all 3 articles

Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: A cross-sectional study

Provisionally accepted
Min Li Min Li Ying Liu Ying Liu Lei Gao Lei Gao Yongli Zheng Yongli Zheng Luyao Chen Luyao Chen Yan Wang Yan Wang *Wei Zhang Wei Zhang
  • Third Hospital of Hebei Medical University, Shijiazhuang, China

The final, formatted version of the article will be published soon.

    Purpose: Sarcopenia, an age-related complication, constitutes a major public health problem given the aging of the population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate the correlations between triglyceride-glucose (TyG) index and TyG-body mass index (BMI) and sarcopenia in non-diabetic middle-aged and older women and whether they would be helpful indicators of sarcopenia.This cross-sectional study was conducted in the Department of Endocrinology, Hebei Medical University Third Hospital. This study prospectively enrolled 460 non-diabetic postmenopausal women aged ≥ 50 years.Results: As TyG and TyG-BMI increased, the prevalence of sarcopenia decreased. In multivariate analysis, the TyG index and TyG-BMI index were inversely associated with sarcopenia (OR: 0.492; 95% CI: 0.256-0.944 and OR: 0.948; 95% CI: 0.934-0.962). Women in the fourth TyG-BMI quartiles showed decreased OR of 0.009 (95% CI: 0.001-0.072) for sarcopenia with respect to first quartiles after adjusting confounding factors. The area under the curve (AUC) for TyG index in the diagnosis of sarcopenia was 0.598 (95% CI: 0.529-0.666), while the AUC for TyG-BMI index was 0.858 (95% CI: 0.816-0.899).Higher TyG index and TyG-BMI index protected against sarcopenia in non-diabetic middle-aged and older females. Moreover, the TyG-BMI index was a reliable and cost-efficient biomarker to predict sarcopenia.

    Keywords: Sarcopenia, Triglyceride-glucose index, Triglyceride glucose-body mass index, Insulin Resistance, middle-aged and older non-diabetic women

    Received: 03 Aug 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Li, Liu, Gao, Zheng, Chen, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yan Wang, Third Hospital of Hebei Medical University, Shijiazhuang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.