Skip to main content

ORIGINAL RESEARCH article

Front. Public Health, 28 February 2023
Sec. Children and Health
This article is part of the Research Topic Fighting Against Vaccine Hesitancy: An Emerging Challenge for Public Health View all 26 articles

Determinants of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in Ethiopia: A multilevel analysis using 2016 demographic and health survey

  • 1Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
  • 2Department of Reproductive Health, School of Public Health, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia
  • 3Department of Reproductive Health, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
  • 4Department of Human Anatomy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
  • 5Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
  • 6Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
  • 7Department of Health Promotion and Health Behavior, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia

Background: Despite remarkable improvements in child health services utilization, childhood immunization has been poorly implemented in Ethiopia. However, evidence on the coverage of immunization among children from mothers/caregivers with no education (non-educated mothers were the most identified risk for underutilization of services) are scarce. Therefore, this study aimed to assess the determinants of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in Ethiopia.

Methods: We analyzed data from the 2016 Ethiopia Demographic and Health Survey (EDHS) on a sample of 1,170 children 12–23 months of age identified from deviant mothers/caregivers (mothers/caregivers with no education) through a two-stage stratified sampling. A multilevel mixed-effect binary logistic regression analysis was used to identify the individual and community level determinants of full immunization coverage among children 12–23 months of age with their deviant mothers/caregivers. In the final model, a p-value of <0.05 and adjusted odds ratio (AOR) with 95% confidence interval (CI) were used to select statistically significant determinants of full immunization coverage.

Results: The overall full immunization coverage among children 12–23 months of age identified from deviant mothers/caregivers was 27.4% (95%CI: 25.0, 31.0) in Ethiopia. Deviant mothers/caregivers who are employed (AOR = 1.69, 95%CI: 1.68, 2.45), being in the rich household wealth status (AOR = 2.54, 95%CI: 1.53, 4.22), residing in city (AOR = 5.69, 95%CI: 2.39, 13.61), having one to three (AOR: 3.28, 95% CI: 2.12–5.07) and four and more ANC follow-up during the recent pregnancy (AOR: 3.91, 95% CI: 2.45, 6.24) were the determinants that increased full immunization coverage among children 12–23 months of age.

Conclusions: Full immunization coverage among children 12–23 months of age from non-educated mothers/caregivers was low and far behind the national target of coverage. Therefore, a system-wide intervention should be used to enhance employability, wealth status, and key maternal health services like ANC follow-up among non-educated mothers/caregivers to increase their children's full immunization coverage.

Background

Immunization has been proven to be one of the most cost-effective health interventions in the world, having successfully averted or eradicated severe childhood diseases (1). Childhood vaccination continues to rise substantially across the globe (2). The global under-five mortality rate has decreased by 59% from 93 deaths per 1,000 live births in 1990 to 38 in 2021 (3). Vaccinations have been found to protect children in poor and middle-income countries against preventable diseases- diphtheria, measles, mumps, pertussis, pneumonia, polio, rotavirus diarrhea, rubella, and tetanus (46).

Children are considered fully vaccinated by the World Health Organization when they have had one dose of Bacillus Calmette Guerin (BCG), three doses of diphtheria-tetanus-pertussis (DTP3), three doses of the polio vaccine, three doses of Pneumococcal conjugate vaccine (PCV3), 3–4 doses of Hepatitis B, three doses of Haemophilus influenza type b (Hib), 2–3 doses of rotavirus, one doses of rubella and one dose of measles vaccine by the age of 5 years (7). According to WHO data for 2021, 84% of children received BCG, 86% received DTP3, 51% received PCV3, and 81% received measles vaccination globally (8). Vaccination coverage has improved significantly in several African countries in the last few decades (9).

Ethiopia launched expanded immunization program in 1980 with the aim of reducing mortality, morbidity, and disability of children from vaccine preventable diseases (10). The program has been freely provided by the public health sector in collaboration with other non-governmental organizations and donors in all regions and districts though district-based strategies and long-term outreach service approaches to achieve the national targets (11). Despite the free provision of immunization services in Ethiopia, full immunization coverage has not been achieved as expected (12). The total immunization coverage was 24.3% in 2011 (13) and 38.3% in 2016 (14). As a result, in Ethiopia, many children have not received the benefit of full immunization (15).

Previous empirical studies focusing on full immunization coverage among children 12–23 months of age and have revealed determinants of full immunization coverage. The identified individual and community level factors are socio-demographic and economic variables like mothers' educational level, residence, household wealth index, maternal marital and occupational status, religion, region, age, and distance to the nearest health facility (1, 14, 1623). Previous obstetric characteristics like having an antenatal care (ANC) visit, place of delivery, parity, number of children and childbirth order were also identified (14, 1618, 20, 24, 25).

Many studies have shown that education is one of the factors significantly associated with full immunization coverage among children (1719, 26). These studies suggest that improving mothers' education will contribute to improving immunization coverage. However, according to EDHS 2016 report, nearly 50% of women have never attended school in Ethiopia (27) moreover, it is not easy to go back and attend the education for mothers at this stage. Despite accessing the same limited resources, specific individuals or groups (underserved populations) in every community can find better solutions and practices to overcome limited access than their peers—which are a positive deviant (28, 29).

A study conducted in Ghana using the positive deviance (PD) approach showed that even the poorest regions (deviant regions) with disparate characteristics and social situations could achieve excellent child immunization coverage (30). The study suggests future exploration using newer DHS data from countries with district-level data, thereby having much larger sample sizes. But evidence on the determinants of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers are still scarce, as most existing literature focuses on both educated and uneducated (14, 17, 18, 23, 24, 31).

Consequently, in this study, we employed the PD approaches to identify mothers/caregivers with positive health behaviors (determinants of full immunization coverage) despite an adverse profile (being uneducated) using recent DHS data. As a result, knowing the positive determinants of full immunization coverage among children 12–23 months of age from mothers/caregivers with a high risk for immunization services underutilization (being uneducated) could help health policy implementers and enable the EPI program to optimize child health initiative performance, and ultimately improve children's health through vaccine services utilization improvement in resource-limited settings with high illiteracy in Ethiopia. The finding is also essential for designing better strategies to improve full immunization coverage and meet child health related targets of sustainable development goal 3.2. Therefore, this study aimed to assess determinants of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in Ethiopia.

Methods

Data sources and context

This analysis was conducted using a cross-sectional data from the EDHS 2016. The EDHS is a nationally representative household survey implemented by the Central Statistical Agency (CSA) of Ethiopia every 5 years (12). Ethiopia was home to more than 120 million people in 2022, of which 16% were children under 5 years (32). Administratively, the country is divided into nine regions [Tigray, Afar, Amhara, Oromia, Benishangul, Gambela, South Nation Nationalities and Peoples' Region (SNNPR), Harari, and Somali] and two City Administrations (Addis Ababa and Dire-Dawa). These nine regions can be divided into developed regions (Tigray, Amhara, Oromia, SNNPR, and Harari) and emerging regions (Afar, Somalia, Benishangul, and Gambela).

A developed region and city administrations have a relatively dense population, better infrastructure, education services and better accessibility to health, including immunization services (33). In contrast, in emerging regions, where scattered pastoralists are the majority. It is common for emerging regions to suffer from inadequate infrastructure, inaccessible health services, droughts, poverty, and a lack of clear and detailed regulations (34).

Sample size and sampling procedures

The Ethiopian CSA performed a population and housing census in 2007, which was utilized as a sample frame for the 2016 EDHS and provided a complete list of 84,915 enumeration areas (27). To select study participants, the EDHS used a two-stage stratified sampling approach. Each stratum had a sample of EAs, which were chosen at random. Accordingly, all children aged 12–23 months who are regular members of the selected households were eligible for the survey. Finally, a total of 1,170 children 12–23 months of age from deviant mothers/caregivers were identified (Figure 1).

FIGURE 1
www.frontiersin.org

Figure 1. Study sample of children 12–23 months of age with their deviant mothers/caregivers in the 2016 Ethiopia DHS (n = 1,170).

Identification of positive deviant mothers/caregivers

To identify the positive deviance of mothers/caregivers for full immunization coverage among children aged 12–23 months and determinants of being positive deviant, Anderson's behavioral model of health service (35) and other related studies were used (1, 17, 20, 23, 36).

Accordingly, education is the primary determinant of health services utilization. We selected mothers/caregivers with no formal education as a sub-group with a very low likelihood of fully immunizing their children, as mother/caregiver education was the strongest predictor of full immunization coverage after adjusting for the other risk factors associated with full immunization coverage among children in this population. Positive deviant mothers/caregivers were those who reported no formal education but their children fully immunized. Finally, in the analysis, we compared the characteristics of the PD mothers/caregivers to those of their counterparts. Due to significant variations by clusters in the overall full immunization coverage among children aged 12–23 months of age from deviant mothers/caregivers, analysis was stratified by individual and community level.

Measurements of variables

The outcome variable for this study was full vaccination coverage among children 12–23 months of age from deviant mothers/caregiver's which is defined as a child who has had one dose of BCG, three doses of pentavalent, three doses of polio, two doses of Rota, three doses of PCV, and one dose of measles (30). If the child had obtained all of the recommended doses of all vaccines, the immunization status was recoded as “1” and classified as “fully immunized”, or if the child had missed one or more doses, the immunization status was recoded as “0” and was classified as “not fully immunized” (14).

Our study assessed independent variables by considering the individual and community-level variables (1, 6, 14, 18, 20, 23). Individual-level variables include, the age of deviant mother/caregivers recoded in completed years (15–24, 25–34, 35+), employment status (employed, non-employed), religion (muslim, orthodox, and other), marital status (married, not married), household wealth status (poor, middle, and rich), head of household (male, female), sex of child (male, female), health insurance coverage (yes, no), i.e., in Ethiopia, community-based health insurance the only health insurance that has been implemented in all regions at household level (37), educational status of husband (no education, primary, secondary, and above), number of ANC visit (no visit, 1–3 visits, 4+ visits), place of delivery (home, health facility), parity (1, 2–5, 6+), childbirth order (1, 2–5, 6+) and uptake of postnatal care (PNC) (yes, no). The uptake of PNC services was assessed whether women received PNC services within 2 months after delivery, regardless of their place of birth. PNC services were assessed based on the mothers/caregiver's verbal responses during the survey. Therefore, it was categorized as “yes” if a woman had at least one PNC visit; otherwise “no.”

The wealth index is a composite measure of a household's cumulative living standard. It is calculated using readily available data on a household's ownership of certain assets, such as televisions and bicycles, materials used for housing construction, and types of water access and sanitation facilities. The household wealth index was originally classified into five categories (poorest, poorer, middle, richer, and richest) by the DHS, which was done with principal component analysis (12). However, for analysis in this study, we divided wealth status into three categories: poor, average, and rich.

On the other hand, the community-level variables include, place of residence (rural, urban), region (emerging region, developed region, and city administration), the difficulty of getting health services (big problem or not big problem) and media exposure. Deviant mothers/caregiver's media exposure was assessed from the three variables: watching television, listening radio, and reading a newspaper, and labeled as “yes” if a woman has exposure to either of the three media sources at least once a week or “no” if a woman has exposure to none of them.

Data processing and analysis

The STATA software version 16 was used to extract, clean, recode, and analyze the data. The descriptive statistics were presented via tables, figures, and narrations. The EDHS data were collected using multistage stratified cluster sampling techniques; as a result, the data had a hierarchical (individuals were nested within communities) nature. Besides, selected and interviewed deviant mothers/caregivers in the same cluster are more likely to be similar to each other than deviant mothers/caregivers from another cluster. This implies that there is a need to consider the between cluster variability by using advanced models. Therefore, to identify determinants, and to estimate the effect of independent variables on full immunization coverage among children 12–23 months of age with their deviant mothers/caregivers, we used the multilevel binary logistic regression analysis method. The Interclass Correlation Coefficient (ICC) and Median Odds Ratio (MOR) were checked to assess whether there was significant clustering or not (38). Accordingly, we found 48% of ICC in our study which showed that 48% of the variation in full coverage among children 12–23 months of age from deviant mothers/caregivers can be explained by clustering.

Four models were fitted in this study—null model (no explanatory variables), model I (individual-level factors), model II (community-level factors), model III (both individual and community-level factors). The ICC and deviance (-2* log-likelihood ratio) were used to evaluate model comparison and fitness. Model III was selected as the best-fitted model since it had the lowest deviance. The proportion of variance (PCV) explained by the grouping structure in the population was calculated to analyze the variation between clusters (39).

In the bivariable analysis, variables with a p-value < 0.2 were considered for multivariable analysis in each three models. Finally, adjusted odds ratios (AOR) with 95% CI and p-value of ≤ 0.05 in the multivariable analysis were used to declare statistically significant determinants of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in the final model. Multicollinearity was tested using the variance inflation factor (VIF). There was a VIF of <5 for each independent variable with a mean VIF of 1.85, indicating no significant multicollinearity between independent variables.

Results

Characteristics of study participants

A total of 1,170 children 12–23 months of age with their deviant mothers/caregivers were included in this analysis (Figure 1). The socio-demographic and economic characteristics of these deviant mothers/caregivers and their children 12–23 months of age are presented in Table 1. The mean age of mothers/caregivers was 30 ± 6.5 years, 64.1% were in poor household wealth status and 57.18% were Muslim religion followers. Moreover, 95.2% of the mothers/caregivers are married and of these married 66.3% of their husbands were uneducated. The mean age of children 12–23 months of age was 16.7 ± 3.4 months and half of children were males.

TABLE 1
www.frontiersin.org

Table 1. Socio-demographic and economic characteristics of deviant mothers/caregivers of children aged 12–23 months in Ethiopia, EDHS 2016 (n = 1,170).

Obstetric characteristics of the deviant mothers/caregivers

Table 2 shows the obstetric characteristics of deviant mothers/caregivers of children aged 12–23 months in Ethiopia. Nearly 45% of deviant mothers/caregivers have not received ANC visits for their recent pregnancy, and 74.5% of the mothers/caregivers gave their recent birth at home. The majority (93.7%) of deviant mothers/caregivers were not received PNC.

TABLE 2
www.frontiersin.org

Table 2. Obstetric characteristics of deviant mothers/caregivers of children aged 12–23 months in Ethiopia, EDHS 2016 (n = 1,170).

Community-level variables for full immunization coverage

The description of community-level factors of full immunization in Ethiopia are presented in Table 3. In this analysis, only 21.45% of deviant mothers/caregivers had access to all media types (radio, newsletter, and television) more than once a week, and 90.2% were rural dwellers. Nearly 40% of the deviant mothers/caregivers were living closer to health facility.

TABLE 3
www.frontiersin.org

Table 3. Health services related and community-level characteristics of deviant mothers/caregivers of children aged 12–23 months in Ethiopia, EDHS 2016 (n = 1,170).

Full immunization coverage among children 12–23 months of age from deviant mothers/caregivers

The overall full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in Ethiopia was 27.4% (95%CI: 25.0, 31.0). Of those fully immunized, 18.1, 30.6, and 38.8% of children with their deviant mothers/caregivers were residing in emerging regions, developed regions, and city administrations, respectively (Figure 2).

FIGURE 2
www.frontiersin.org

Figure 2. Full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in the 2016 Ethiopia DHS (n = 1,170).

Measure of variation using random effects and model fitness

There was a significant variation in full immunization coverage among children 12–23 months of age from deviant mothers/caregivers across clustering. The model fitness was checked using the ICC across, Akaike's Information Criterion (AIC) and deviance as presented in Table 4. Then model three (a model with both individual and community level factors) was best (low deviance and AIC) and chosen for the final analysis to identify the determinants of full immunization coverage.

TABLE 4
www.frontiersin.org

Table 4. Random-intercept model of multilevel analysis for full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in Ethiopia, EDHS 2016.

Factors affecting full immunization coverage among children 12–23 months of age from deviant mothers/caregivers

After adjusting for individual and community level factors, deviant mothers/caregivers who are employed, rich household wealth status, had ANC follow-up, and residing in city administrations were statistically significant determinants of full immunization coverage as presented in Table 5.

TABLE 5
www.frontiersin.org

Table 5. A mixed effect multilevel logistic regression analysis of individual and community-level factors associated with full immunization coverage among deviant mothers/caregiver's children aged 12–23 months in Ethiopia, EDHS 2016 (n = 1,170).

Hence, the odds of full immunization coverage among children 12–23 months of age from employed deviant mothers/caregivers was 1.69 higher than the odds of full immunization among children 12–23 months of age from non-employed deviant mothers/caregivers (AOR = 1.69, 95% CI: 1.68, 2.45). The odds of full immunization coverage among children aged 12–23 months of deviant mothers/caregivers from wealthy households were 2.54 higher than those from poor households (AOR = 2.54, 95%CI: 1.53, 4.22). The odds of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers who reside in the city administration was 5.69 higher than that of deviant mothers/caregivers who reside in the emerging regions (AOR: 5.69, 95% CI: 2.39, 13.61). The odds of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers who had 1–3 and greater or equal to four ANC follow up were 3.28 (AOR: 3.28, 95% CI: 2.12–5.07) and 3.91 (AOR: 3.91, 95% CI: 2.45, 6.24) higher than their counterparts, respectively.

Discussion

This study identifies determinants that significantly increase the full immunization coverage among children 12–23 months of age from mothers/caregivers at high risk for low vaccine uptake (mothers/caregivers who do not have an education) in Ethiopia. Mothers/caregivers with no formal education are at particularly high risk for low immunization coverage among children aged 12–23 months and are consequently a key target group for improving childhood vaccine utilization. Identifying the positive determinants of PD behavior could be used to guide high-impact interventions to improve children's health in Ethiopia, where a significant proportion of mothers/caregivers are illiterate.

The overall full immunization coverage among children 12–23 months of age from deviant mothers/caregivers was 27.4% (95%CI: 25.0, 31.0). This finding is very low compared to previous studies estimates of full immunization coverage among children aged 12–23 months range from 36 to 77.4% in Ethiopia (1, 14, 17, 18, 23, 31), Kenya (40), Senegal (41), Burkina Faso (21), Nigeria (20), Indonesia (25), and Mozambique (22). This could be due to differences in outcome variable measurement, cultural practices, and study participants; for example, previous studies included both educated and uneducated mothers/caregivers, whereas our study only looked at mothers/caregivers with no formal education. Mothers/caregivers with no formal education may be unaware of the benefits of childhood immunization programs. Furthermore, mothers/caregivers without a formal education are less likely to engage in paid work and are more financially dependent on others. Even though immunization services have been provided freely, obtaining childhood immunization services still has an indirect cost. As a result, they may be unable to access these services for their children. On the other hand the differences in study periods, health system performance differences among countries, and the number of newly introduced vaccines like PCV and Rota incorporated into the definition of full expanded immunization program in Ethiopia can explain the variations (14).

The current study finding revealed that deviant mothers/caregiver's household wealth status, region, employment status, and ANC follow-up were statistically significant determinants of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers and in concert with prior studies risk factor analysis (1, 14, 17, 18, 20, 31, 41).

We found that full immunization coverage among children 12–23 months of age from deviant mothers/caregivers who were employed was higher than those who do not employed. This finding agrees with the results of previous studies conducted in Ethiopia (14, 17), and Nigeria (20). This could be due to employed mothers/caregivers having better information about the benefits of childhood services including immunization, and also, they can cover the indirect cost of accessing the vaccine service. This implies that policymakers should create opportunities for mothers/caregivers to work and to become financially independent.

Our finding revealed that full immunization coverage among children 12–23 months of age from wealthy household deviant mothers/caregivers were higher than those with the poor wealth status supported with findings from other studies conducted Ethiopia (1, 6, 14, 17, 23), Indonesia (25), and Bangladesh (42). This could be inequalities in accessing healthcare between poor and wealthy households. Children from impoverished parents may face challenges in reaching health facilities compared to wealthy households (43); because low-income families had to incur high costs and take their time to maintain their daily lives. The other possible explanation could be that wealthier households have increased childcare practices and better health-seeking behavior (44). In contrast, studies conducted in Pakistan (45) revealed that household wealth status was not statistically associated with full immunization coverage. This could be because immunization is universal, and wealth no longer has as big of an impact on full immunization coverage as it formerly did because immunization offered through the EPI program is free, and public efforts to reach vulnerable mothers and children are continued (14). This implies that policymakers should continue to focus on developing interventions, initiatives, and expanding existing programs aimed at empowering women to develop their income and become economically self-sufficient. Consequently, their children will have better access to health services, including immunization.

In our study, full immunization coverage among children 12–23 months of age from deviant mothers/caregivers who reside in the city administration was higher than that of deviant caregivers who reside in the emerging regions. Similarly, studies conducted in Ethiopia showed that regions are significantly associated with full immunization coverage (6, 17). This could be due to regional differences in vaccine procurement, supply, cold chain, or other logistics issues (46, 47). This might also be due to differences in cultural beliefs, population size, topography, and levels of development, and this could be linked with differences in the availability of healthcare providers, vaccine and commodities. Hence, these regional differences tend to affect the range of childhood immunization uptake across the country (43). This implies that the government should improve infrastructure, i.e., electricity, transportation, and water, as well as health facilities, to increase the accessibility and uptake of full immunization among children in emerging regions.

In this study, fully immunization coverage among children 12–23 months of age from deviant mothers/caregivers who had 1–3 and greater or equal to four ANC follow up was higher than their counterparts. This finding is in line with the results of previous studies conducted in Ethiopia (1, 14, 17, 48, 49), Senegal (41), Nigeria (50), Uganda (51), Pakistan (45), and Indonesia (25). This could be because increased contact with a healthcare facility for ANC would promote full immunization coverage among children, giving mothers more opportunities to learn about child health, particularly the importance of vaccines, and be encouraged to immunized their children by healthcare professionals (52). This implies that policymakers should develop strategies to increase ANC service utilization by improving health facility accessibility and quality, and creating awareness through mass campaigns, which may ultimately increase the full immunization coverage.

Strengths and limitations of the study

The positive deviance approach was used for the first time in Ethiopia to identify positive determinants for full immunization coverage among children 12–23 months of age from deviant mothers/caregivers. Non-educated mothers/caregivers are at high risk of their children's getting full immunization coverage so; identifying determinants using this positive deviance approach can improve the child health services policy in the country which can be transferable to other similar settings. In addition, multilevel analysis was employed to account for the hierarchical nature of the EDHS data to obtain reliable standard errors and estimates. Furthermore, because it is based on national survey data with large sample size, the study has the potential to give evidence for policymakers, program planners, and other stakeholders on how to create relevant interventions at both the national and regional levels to improve full immunization coverage among children. However, the findings of the study are interpreted with some limitations. We cannot show the temporal association between full immunization coverage among children aged 12–23 months of deviant mothers/caregivers and independent variables due to the cross-sectional nature of the survey. Since the EDHS survey relied on the respondents' reports, there might be a chance of recall bias.

Conclusions

In Ethiopia, full immunization coverage among children 12–23 months of age from deviant mothers/caregivers is still low, and far behind the national target of full immunization coverage. The deviant mothers/caregiver's employment status, household wealth status, region, and ANC follow-up were associated with PD behavior and full immunization coverage. The positive deviance approach provides evidence for health policy makers and program implementers to identify determinants facilitating improved health behavior and, ultimately, better child health outcomes despite an acknowledged adverse risk profile. Such strategies and knowledge could facilitate targeted efforts aimed to improve child health outcomes and meet the national targets of child morbidity and mortality. Therefore, improving mothers/caregivers' employability, wealth status, and ANC follow-up will contribute to full immunization coverage improvement among children 12–23 months of age from deviant mothers/caregivers.

Data availability statement

The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article/supplementary material.

Ethics statement

Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements. Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. Written informed consent was not obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.

Author contributions

SM, DB, EF, and DA conceived the idea for this study. SM is involved in the data extraction, analysis, interpretation of the finding, and writing the original draft. DB and WD assisted in the analysis of the study. ES, RT, TA, HE, and FA writing the review and editing the manuscript. All the authors read and approved the final manuscript.

Acknowledgments

We are very thankful to the major DHS program which permitted us to use the DHS survey data sets.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Abbreviations

AOR, Adjusted Odds Ratio; CI, Confidence Intervals; COR, Crude Odds Ratio; DHS, Demographic and Health Survey; ICC, Intra-Cluster Correlation; OR, Odds Ratio; PCV, Proportional Change in Variance; WHO, World Health Organization; MOR, Median Odds Ratio; LLR, Likelihood Ratio Test; PD, Positive Deviance; ANC, Antenatal care; EPI, Expanded Program for Immunization; DTP3, Diphtheria-Tetanus-Pertussis.

References

1. Etana B, Deressa W. Factors associated with complete immunization coverage in children aged 12–23 months in Ambo Woreda, Central Ethiopia. BMC Public Health. (2012) 12:9. doi: 10.1186/1471-2458-12-566

CrossRef Full Text | Google Scholar

2. World Health Organization. WHO Vaccine-preventable Diseases: Monitoring System: 2009 Global Summary. Geneva: World Health Organization (2009).

Google Scholar

3. data U: UNICEF. Monitoring the Situation of Children and Women. UNICEF (2021).

Google Scholar

4. Lee EHJ, Lewis RF, Makumbi I, Kekitiinwa A, Ediamu TD, Bazibu M, et al. Haemophilus influenzae type b conjugate vaccine is highly effective in the Ugandan routine immunization program: a case–control study. Trop Med Int Health. (2008) 13:495–502. doi: 10.1111/j.1365-3156.2008.02027.x

CrossRef Full Text | Google Scholar

5. Danielsson N, Fakakovikaetau T, Szegedi E. Improved immunization practices reduce childhood hepatitis B infection in Tonga. Vaccine. (2009) 27:4462–7. doi: 10.1016/j.vaccine.2009.05.051

PubMed Abstract | CrossRef Full Text | Google Scholar

6. Wondwossen L, Gallagher K, Braka F, Karengera T. Advances in the control of vaccine preventable diseases in Ethiopia. Pan Afr Med J. (2017) 27(Suppl. 2). doi: 10.11604/pamj.supp.2017.27.2.12701

PubMed Abstract | CrossRef Full Text | Google Scholar

7. WHO. WHO Recommendation for Routine Immunization 2021. Geneva: WHO (2021).

Google Scholar

8. Rachlin A. Routine vaccination coverage—worldwide 2021. MMWR Morb Mort Weekly Rep. (2022) 71:mm7144a2. doi: 10.15585/mmwr.mm7144a2

CrossRef Full Text | Google Scholar

9. Ali HA, Hartner A-M, Echeverria-Londono S, Roth J, Li X, Abbas K, et al. Vaccine equity in low and middle income countries: a systematic review and meta-analysis. Int J Equity Health. (2022) 21:1–30. doi: 10.1186/s12939-022-01678-5

PubMed Abstract | CrossRef Full Text | Google Scholar

10. Maternal CND. Federal Ministry of Health, Ethiopia: National Implementation Guideline for Expanded Program on Immunization. Ethiopia: Maternal CND (2021).

Google Scholar

11. FDRo E. National Expanded Programme on Immunization Comprehensive Multi-year Plan 2011–2015. Addis Ababa: Fedral Ministry of Health (2010).

Google Scholar

12. CSAC. Ethiopia Demographic and Health Survey 2016. Addis Ababa, Ethiopia, and Rockville, MD: CSA; ICF (2016).

Google Scholar

13. Authority CS. Ethiopia Demographic and Health Survey 2000 (2001).

PubMed Abstract | Google Scholar

14. Tamirat KS, Sisay MM. Full immunization coverage and its associated factors among children aged 12–23 months in Ethiopia: further analysis from the 2016. Ethiopia demographic and health survey. BMC Public Health. (2019) 19:7. doi: 10.1186/s12889-019-7356-2

CrossRef Full Text | Google Scholar

15. Machingaidze S, Wiysonge CS, Hussey GD. Strengthening the expanded programme on immunization in Africa: looking beyond 2015. PLoS Med. (2013) 10:e1001405. doi: 10.1371/journal.pmed.1001405

PubMed Abstract | CrossRef Full Text | Google Scholar

16. Lakew Y, Bekele A, Biadgilign S. Factors influencing full immunization coverage among 12–23 months of age children in Ethiopia: evidence from the national demographic and health survey in 2011. BMC Public Health. (2015) 15:8. doi: 10.1186/s12889-015-2078-6

CrossRef Full Text | Google Scholar

17. Debie A, Amare G, Handebo S, Mekonnen ME, Tesema GA. Individual-and community-level determinants for complete vaccination among children aged 12-23 months in Ethiopia: a multilevel analysis. BioMed Res. Int. (2020) 2020:6907395. doi: 10.1155/2020/6907395

PubMed Abstract | CrossRef Full Text | Google Scholar

18. Girmay A, Dadi AF. Full immunization coverage and associated factors among children aged 12-23 months in a hard-to-reach areas of Ethiopia. Int. J. Pediatr. (2019) 2019:1924941. doi: 10.1155/2019/1924941

PubMed Abstract | CrossRef Full Text | Google Scholar

19. Beyene EZ, Worku A, Bisrat F, Fantahun M. Factors associated with immunization coverage among children age 12-23 months: the case of Zone 3, Afar Regional State, Ethiopia. Ethiop Med J. (2013) 51:41–50.

PubMed Abstract | Google Scholar

20. Fatiregun AA, Okoro AO. Maternal determinants of complete child immunization among children aged 12–23 months in a southern district of Nigeria. Vaccine. (2012) 30:730–6. doi: 10.1016/j.vaccine.2011.11.082

CrossRef Full Text | Google Scholar

21. Sanou A, Simboro S, Kouyaté B, Dugas M, Graham J, Bibeau G. Assessment of factors associated with complete immunization coverage in children aged 12-23 months: a cross-sectional study in Nouna district, Burkina Faso. BMC Int Health Hum Rights. (2009) 9:15. doi: 10.1186/1472-698X-9-S1-S10

PubMed Abstract | CrossRef Full Text | Google Scholar

22. Shemwell SA, Peratikos MB, Gonzalez-Calvo L, Renom-Llonch M, Boon A, Martinho S, et al. Determinants of full vaccination status in children aged 12–23 months in Gurùé and Milange districts, Mozambique: results of a population-based cross-sectional survey. Int Health. (2017) 9:234–42. doi: 10.1093/inthealth/ihx020

PubMed Abstract | CrossRef Full Text | Google Scholar

23. Yadita ZS, Ayehubizu LM. Full immunization coverage and associated factors among children aged 12–23 months in Somali Region, Eastern Ethiopia. PLoS ONE. (2021) 16:e0260258. doi: 10.1371/journal.pone.0260258

PubMed Abstract | CrossRef Full Text | Google Scholar

24. Enyew EB, Tareke AA. Vaccination status and factors associated among children age 12–23 months in Ethiopia, based on 2016. EDHS: Logit based multinomial logistic regression analysis. PLoS ONE. (2022) 17:e0264004. doi: 10.1371/journal.pone.0264004

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Efendi F, Pradiptasiwi DR, Krisnana I, Kusumaningrum T, Kurniati A, Sampurna MTA, et al. Factors associated with complete immunizations coverage among Indonesian children aged 12–23 months. Child Youth Serv Rev. (2020) 108:104651. doi: 10.1016/j.childyouth.2019.104651

PubMed Abstract | CrossRef Full Text | Google Scholar

26. Mukungwa T. Factors associated with full immunization coverage amongst children aged 12–23 months in Zimbabwe. Afr Popul Stud. (2015) 29:745. doi: 10.11564/29-2-745

CrossRef Full Text | Google Scholar

27. Csa I. Central Statistical Agency (CSA) [Ethiopia] and ICF. Addis Ababa, Ethiopia; Calverton, MD: Ethiopia Demographic and Health Survey (2016). p. 1.

Google Scholar

28. Baxter R, Taylor N, Kellar I, Lawton R. What methods are used to apply positive deviance within healthcare organisations? A systematic review. BMJ Qual Safety. (2016) 25:190. doi: 10.1136/bmjqs-2015-004386

PubMed Abstract | CrossRef Full Text | Google Scholar

29. Marsh DR, Schroeder DG, Dearden KA, Sternin J, Sternin M. The power of positive deviance. BMJ. (2004) 329:1177. doi: 10.1136/bmj.329.7475.1177

CrossRef Full Text | Google Scholar

30. Kyere P. Complete child immunization: a cluster analysis of positive deviant regions in Ghana. J Vacc Vaccin. (2017) 8:1–7. doi: 10.4172/2157-7560.1000351

CrossRef Full Text | Google Scholar

31. Facha W. Fully vaccination coverage and associated factors among children aged 12 to 23 months in Arba Minch Zuriya Woreda, Southern Ethiopia. J Pharm Altern Med. (2015) 7:19–25. Available online at: https://core.ac.uk/download/pdf/234689511.pdf

Google Scholar

32. UNEP. Population Estimation E: World Population Dashboard Ethiopia. New York, NY: UNEP (2022). Available online at: https://www.unfpa.org/data/world-population/ET

Google Scholar

33. Gebremedhin T, Aschalew AY, Tsehay CT, Dellie E, Atnafu A. Micronutrient intake status and associated factors among children aged 6–23 months in the emerging regions of Ethiopia: a multilevel analysis of the 2016. Ethiopia demographic and health survey. PLoS ONE. (2021) 16:e0258954. doi: 10.1371/journal.pone.0258954

CrossRef Full Text | Google Scholar

34. Gebre-Egziabhere T. Emerging Regions in Ethiopia: are they catching up with the rest of Ethiopia? East Afr Soc Sci Res Rev. (2018) 34:1–36. doi: 10.1353/eas.2018.0000

CrossRef Full Text | Google Scholar

35. Andersen RM. Revisiting the behavioral model and access to medical care: does it matter? J Health Soc Behav. (1995) 36:1–10. doi: 10.2307/2137284

PubMed Abstract | CrossRef Full Text | Google Scholar

36. Meleko A, Geremew M, Birhanu F. Assessment of child immunization coverage and associated factors with full vaccination among children aged 12–23 months at Mizan Aman town, bench Maji zone, Southwest Ethiopia. Int J Pediatr. (2017) 2017:7976587. doi: 10.1155/2017/7976587

PubMed Abstract | CrossRef Full Text | Google Scholar

37. Abdilwohab MG, Abebo ZH, Godana W, Ajema D, Yihune M, Hassen H. Factors affecting enrollment status of households for community based health insurance in a resource-limited peripheral area in Southern Ethiopia. Mixed method. PLoS ONE. (2021) 16:e0245952. doi: 10.1371/journal.pone.0245952

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Hox JJ, Moerbeek M, Van de Schoot R. Multilevel Analysis: Techniques and Applications. 3rd edn. New York, NY: Routledge (2017). doi: 10.4324/9781315650982

CrossRef Full Text | Google Scholar

39. Merlo J, Chaix B, Yang M, Lynch J, Råstam L. A brief conceptual tutorial of multilevel analysis in social epidemiology: linking the statistical concept of clustering to the idea of contextual phenomenon. J Epidemiol Commun Health. (2005) 59:443–9. doi: 10.1136/jech.2004.023473

PubMed Abstract | CrossRef Full Text | Google Scholar

40. Mutua MK, Kimani-Murage E, Ngomi N, Ravn H, Mwaniki P, Echoka E. Fully immunized child: coverage, timing and sequencing of routine immunization in an urban poor settlement in Nairobi, Kenya. Trop Med Health. (2016) 44:1–12. doi: 10.1186/s41182-016-0013-x

PubMed Abstract | CrossRef Full Text | Google Scholar

41. Mbengue MAS, Sarr M, Faye A, Badiane O, Camara FBN, Mboup S, et al. Determinants of complete immunization among senegalese children aged 12–23 months: evidence from the demographic and health survey. BMC Public Health. (2017) 17:1–9. doi: 10.1186/s12889-017-4493-3

PubMed Abstract | CrossRef Full Text | Google Scholar

42. Boulton ML, Carlson BF, Power LE, Wagner AL. Socioeconomic factors associated with full childhood vaccination in Bangladesh, 2014. Int J Infect Dis. (2018) 69:35–40. doi: 10.1016/j.ijid.2018.01.035

PubMed Abstract | CrossRef Full Text | Google Scholar

43. Abadura SA, Lerebo WT, Kulkarni U, Mekonnen ZA. Individual and community level determinants of childhood full immunization in Ethiopia: a multilevel analysis. BMC Public Health. (2015) 15:10. doi: 10.1186/s12889-015-2315-z

PubMed Abstract | CrossRef Full Text | Google Scholar

44. Peters DH, Garg A, Bloom G, Walker DG, Brieger WR, Hafizur Rahman M. Poverty and access to health care in developing countries. Ann N Y Acad Sci. (2008) 1136:161–71. doi: 10.1196/annals.1425.011

PubMed Abstract | CrossRef Full Text | Google Scholar

45. Noh J-W, Kim Y-m, Akram N, Yoo K-B, Park J, Cheon J, et al. Factors affecting complete and timely childhood immunization coverage in Sindh, Pakistan; a secondary analysis of cross-sectional survey data. PLoS ONE. (2018) 13:e0206766. doi: 10.1371/journal.pone.0206766

PubMed Abstract | CrossRef Full Text | Google Scholar

46. O'Donnell O. Access to health care in developing countries: breaking down demand side barriers. Cad Saude Publica. (2007) 23:2820–34. doi: 10.1590/S0102-311X2007001200003

PubMed Abstract | CrossRef Full Text | Google Scholar

47. Legesse E, Dechasa W. An assessment of child immunization coverage and its determinants in Sinana District, Southeast Ethiopia. BMC Pediatr. (2015) 15:14. doi: 10.1186/s12887-015-0345-4

PubMed Abstract | CrossRef Full Text | Google Scholar

48. Dessie DB, Negeri MA. Determining factors of full immunization of children among 12-23 months old in rural Ethiopia. Am J Public Health Res. (2018) 6:160–5. doi: 10.12691/ajphr-6-3-6

CrossRef Full Text | Google Scholar

49. Asmamaw A, Getachew T, Gelibo T, Taye G, Bekele A, Teklie H, et al. Determinants of full valid vaccine dose administration among 12-32 months children in Ethiopia: evidence from the Ethiopian 2012 national immunization coverage survey. Ethiop J Health Dev. (2016) 30:135–41.

Google Scholar

50. Funmilayo A. Determinants of full child immunization among 12-23 months old in Nigeria (Msc thesis). University of the Witswatersrand. Demography and Population (2015).

Google Scholar

51. Bbaale E. Factors influencing childhood immunization in Uganda. J Health Popul Nutr. (2013) 31:118. doi: 10.3329/jhpn.v31i1.14756

PubMed Abstract | CrossRef Full Text | Google Scholar

52. Dixit P, Dwivedi LK, Ram F. Estimating the Impact of Antenatal Care Visits on Institutional Delivery in India: A Propensity Score Matching Analysis (2013). Available online at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=31925

Google Scholar

Keywords: full immunization, positive deviance, multilevel-mixed effect, Ethiopia, EDHS 2016

Citation: Mihret Fetene S, Debebe Negash W, Shewarega ES, Asmamaw DB, Belay DG, Teklu RE, Aragaw FM, Alemu TG, Eshetu HB and Fentie EA (2023) Determinants of full immunization coverage among children 12–23 months of age from deviant mothers/caregivers in Ethiopia: A multilevel analysis using 2016 demographic and health survey. Front. Public Health 11:1085279. doi: 10.3389/fpubh.2023.1085279

Received: 31 October 2022; Accepted: 07 February 2023;
Published: 28 February 2023.

Edited by:

Pasquale Stefanizzi, University of Bari Aldo Moro, Italy

Reviewed by:

Sidikiba Sidibe, Gamal Abdel Nasser University of Conakry, Guinea
Shantanu Sharma, Lund University Library, Lund University, Sweden

Copyright © 2023 Mihret Fetene, Debebe Negash, Shewarega, Asmamaw, Belay, Teklu, Aragaw, Alemu, Eshetu and Fentie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Samrawit Mihret Fetene, yes samrimih21@gmail.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.