Giulia Poggi
Anes Ju
Esther Castillo-Gómez- 1Department of Psychiatry and Psychotherapy & Institute of Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
- 2Samsung Advanced Institute of Technology (SAIT), Samsung Electronics, Suwon-si, Republic of Korea
- 3Department of Medicine, School of Medical Sciences, Universitat Jaume I, Castelló de la Plana, Spain
- 4Spanish National Network for Research in Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Editorial on the Research Topic
Understanding of brain cellular dysfunction in psychiatric disorders-relevant phenotypes: from humans to models
The World Health Organization (WHO) reports that one in eight individuals globally is affected by mental disorders, including psychiatric illnesses and neurodevelopmental pathologies, highlighting the profound and widespread impact of these conditions. These individuals often endure substantial cognitive, emotional, and behavioural dysfunctions, particularly when access to effective treatments is limited. The category of mental disorders encompasses a broad spectrum of pathological conditions, including schizophrenia (SCZ), depression, anxiety disorders, bipolar disorders, post-traumatic stress disorders (PTSD), eating disorders, disruptive behaviour/dissocial disorders, and neurodevelopmental disorders such as autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD)1.
Both environmental and genetic factors, as well as their interaction, are well-established contributors to the onset of mental disorders (1). However, the inherent complexity, heterogeneity, and multifactorial nature of these disorders have hindered significant progress in pinpointing the specific molecular and cellular pathways involved. Indeed, to date, there is no consensus on the underlying pathophysiology of mental disorders.
To address this challenge and advance the field, the National Institute of Mental Health (NIMH) introduced the Research Domain Criteria (RDoC) framework (2). Unlike traditional clinical diagnostic approaches, the RDoc framework examines mental disorders by assessing the dysfunction of specific behavioural and biological systems that may be shared across different conditions.
Inspired by this innovative approach, we have assembled a collection of preclinical and clinical studies focused on cell type-specific functions that are implicated in the onset or exacerbation of psychiatric symptoms. This Research Topic includes three research articles (Wei et al.; Pan et al.; Buttermore et al.) and one review (Hassamal) that explore the role of excitatory neurons, neurotrophic factors and inflammasome in mental disorders. Specifically, through the implementation of induced-pluripotent stem cells (iPSCs) system, Buttermore et al. explored the impact of the 16p13.11 deletion - associated with increased risk for SCZ and ADS - on the morphology, activity, and synaptic properties of iPSCs-derived cortical neurons. Their findings revealed an increased number of Synapsin-1+/PSD95+synapses, altered neuron development-related transcriptome and synaptic formation, and increased neuronal branching in probands compared to non-carrier controls, irrespective of deletion size (Buttermore et al.).
Similarly, Wei et al. identified 247 genes associated with ADHD by integrating genome-wide association study (GWAS) data with brain expression quantitative trait locus (eQTL) data using summary-data-based Mendelian randomization (SMR). Their findings revealed that these ADHD risk genes are primarily enriched in brain tissues, particularly within the mesencephalon, visual cortex, and frontal lobe regions. Further cell-type-specific analysis indicated that these genes are highly expressed in excitatory neurons (Wei et al.). These results, although preliminary, suggest that the aetiology of ADHD may involve mechanisms related to excitatory neurons in these brain regions, potentially overlapping with the pathophysiology of conditions like SCZ and ADS.
Further, Pan et al. explored the pathophysiology of SCZ from the perspective of common variations - specifically single nucleotide polymorphisms (SNPs) - in genes encoding for brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9). Their study confirmed an increased likelihood of developing SCZ in patients carrying the BDNF rs6265 196 G>A (GG or GA genotypes), although the MMP-9 rs3918242-1562 C>T SNP showed no association. Notably, BDNF GG and MMP-9 CC genotypes were associated with higher Positive and Negative Syndrome Scale (PANSS) scores as compared to other genotypes (Pan et al.).
Lastly, a review by Hassamal highlighted emerging inflammation-related mechanisms that connect chronic stress to depression onset, emphasising the critical role of neurotrophic factors, including BDNF, in immune regulation. This review also noted ongoing research into dipeptides that mimic BDNF and specifically target the tyrosine kinase B (TkB) receptor as potential treatments for depression (Hassamal).
While these studies underscore the importance of mechanisms relevant to mental disorders and call for further confirmatory research, it is important to recognize that they do not offer a comprehensive overview of the biological substrates currently under investigation in mental illness. For instance, substantial evidence has also consistently implicated inhibitory neurons and glia cells in the onset of mental disorders (for relevant reviews, see (3–8).
In summary, while the field of research in mental disorders has still a long way to go, a collective effort to explore relevant cellular and molecular mechanisms - possibly through the implementation of the RDoC framework rather than conventional diagnostic criteria - holds promise for unravelling the complexity of mental illnesses and determining their underlying pathophysiology. Understanding these mechanisms is crucial not only for advancing our knowledge but also for developing more effective therapeutic approaches, ultimately improving the treatment and management of mental health disorders.
Author contributions
GP: Writing – original draft, Writing – review & editing. AJ: Writing – original draft, Writing – review & editing. EC: Writing – original draft, Writing – review & editing.
Conflict of interest
Author AJ was employed by Samsung Electronics.
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Footnotes
References
1. Tsuang MT, Bar JL, Stone WS, Faraone SV. Gene-environment interactions in mental disorders. World Psychiatry. (2004) 3:73–83.
2. Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. (2010) 167:748–51. doi: 10.1176/appi.ajp.2010.09091379
3. Lewis DA, Hashimoto T, Volk DW. Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci. (2005) 6:312–24. doi: 10.1038/nrn1648
4. Marín O. Interneuron dysfunction in psychiatric disorders. Nat Rev Neurosci. (2012) 13:107–20. doi: 10.1038/nrn3155
5. Nacher J, Guirado R, Castillo-Gómez E. Structural plasticity of interneurons in the adult brain: role of PSA-NCAM and implications for psychiatric disorders. Neurochem Res. (2013) 38:1122–33. doi: 10.1007/s11064-013-0977-4
6. Haroutunian V, Katsel P, Roussos P, Davis KL, Altshuler LL, Bartzokis G. Myelination, oligodendrocytes, and serious mental illness. Glia. (2014) 62:1856–77. doi: 10.1002/glia.22716
7. Elsayed M, Magistretti PJ. A new outlook on mental illnesses: glial involvement beyond the glue. Front Cell Neurosci. (2015) 9:468. doi: 10.3389/fncel.2015.00468
Keywords: mental disorders, excitatory neurons, neurotrophic factors, inflammasome, inhibitory neurons, glia cells
Citation: Poggi G, Ju A and Castillo-Gómez E (2024) Editorial: Understanding of brain cellular dysfunction in psychiatric disorders-relevant phenotypes: from humans to models. Front. Psychiatry 15:1487010. doi: 10.3389/fpsyt.2024.1487010
Received: 27 August 2024; Accepted: 29 August 2024;
Published: 11 September 2024.
Edited and Reviewed by:
Ming D. Li, Zhejiang University, ChinaCopyright © 2024 Poggi, Ju and Castillo-Gómez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Esther Castillo-Gómez, ZXNjYXN0aWxAdWppLmVz