Fei Jiang
Jinsong Huang1- 1Department of Psychiatry, Dalian Seventh People’s Hospital, Dalian, China
- 2Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China
Introduction: Sleep disorders often coexist with personality and psychological issues, alongside nocturnal hypoxia. This study investigates the potential mediating role of nocturnal hypoxia between personality traits and psychological symptoms in individuals with sleep disorders.
Methods: A cohort comprising 171 participants reporting sleep disturbances was recruited from Dalian Seventh People’s Hospital. Psychological symptoms were assessed using the Symptom Checklist-90-R (SCL-90-R), while personality traits were evaluated using the Eysenck Personality Questionnaire (EPQ). Nocturnal hypoxia status was determined through overnight polysomnography.
Results: Mediation analysis, conducted using SPSS 23.0, demonstrated that the cumulative time of nocturnal peripheral oxygen saturation (SpO2) < 85% (T85) partially mediated the relationship between neuroticism and various psychological symptoms, including somatization (c=0.207, c’=0.164, a*b=0.043, proportion of mediation 20.8%), interpersonal sensitivity (c=0.360, c’=0.326, a*b=0.034, proportion of mediation 9.6%), depression (c=0.277, c’=0.234, a*b=0.042, proportion of mediation 15.3%), anxiety (c=0.240, c’=0.199, a*b=0.041, proportion of mediation 16.9%), hostility (c=0.241, c’=0.205, a*b=0.036, proportion of mediation 14.9%), phobic anxiety (c=0.271, c’=0.241, a*b=0.030, proportion of mediation 11.1%), and psychoticism (c=0.298, c’=0.266, a*b=0.032, proportion of mediation 10.8%).
Discussion: These findings underscore the potential mediating role of nocturnal hypoxia in the association between neuroticism personality traits and psychological symptoms among individuals with sleep disorders. Our research holds considerable significance in advancing the quest for personalized treatments targeting psychological symptoms in individuals with sleep disorders.
1 Introduction
Sleep disorders often coexist with personality and psychological issues, alongside nocturnal hypoxia. Personality traits and psychological symptoms are fundamental aspects of human behavior and mental well-being (1). Personality traits encompass enduring patterns of cognition, emotion, and behavior that consistently characterize individuals across diverse contexts. In contrast, psychological symptoms represent deviations from typical functioning and encompass a broad spectrum of psychological phenomena, including mood dysregulation, cognitive disturbances, and behavioral aberrations. Extensive research has investigated the associations between personality traits and various psychological disorders, including depression, anxiety, and schizophrenia (2–4). For example, individuals with elevated levels of psychopathic traits often exhibit deficits in empathy and engage in coercive behaviors, with a propensity towards multiple forms of violence (5). Specific personality traits may predispose individuals to particular psychological symptoms, modulate symptom severity, and influence treatment outcomes. Maladaptive personality traits characterized by internalizing tendencies and psychoticism have been linked to heightened psychological distress (6). Additionally, vulnerability traits have been reported to negatively impact anxiety and depression, especially in the context of the COVID-19 pandemic (7). While personality traits generally demonstrate relative stability over time, psychological symptoms exhibit variability in intensity and manifestation, often fluctuating in response to internal and external stressors. Moreover, personality traits are intricately intertwined with stress responsivity under certain psychological circumstances. For instance, research has shown that levels of salivary enzymes may increase in individuals exhibiting traits such as neuroticism, extraversion, agreeableness, and rumination in response to psychological stressors (8). Studies have also explored the relationship between personality traits and specific psychological symptoms. For instance, research on internet addiction in teenagers found that certain personality traits were associated with higher scores on measures of psychological distress (9). Similarly, studies examining the Big Five personality traits revealed positive associations between neuroticism and openness and COVID-19 anxiety (10). Additionally, self-reported personality, particularly neuroticism, has been prospectively associated with a broad spectrum of behavioral symptoms among individuals with cognitive impairment nearing the end of life (11). Furthermore, alterations in personality traits such as neuroticism, extraversion, openness to experiences, and conscientiousness have been linked to symptoms of apathy and affective symptoms among patients diagnosed with mild cognitive impairment (12). Furthermore, alterations in personality traits such as neuroticism, extraversion, openness to experiences, and conscientiousness have been linked to symptoms of apathy and affective symptoms among patients diagnosed with mild cognitive impairment (13). In the realm of psychotherapy, a cohort study discovered that individuals with a combined high extraversion and high neuroticism personality score at baseline were more likely to receive benzodiazepine prescriptions (14).
On the other hand, Hypoxia has been identified as a factor associated with psychological symptoms. Previous research has indicated that prolonged exposure to anoxic environments can precipitate neuropsychiatric disorders and heighten the vulnerability to depression, anxiety, and other psychological issues (15, 16). Furthermore, residing at high altitudes has been linked to an increased risk of depression and suicide (17, 18). Acute exposure to high-altitude hypoxia has been shown to induce adverse neurological effects (19). Moreover, emerging lines of evidence suggest a potential role of hypoxia in the pathophysiology of schizophrenia (20–23). Intriguingly, depression and anxiety disorders are frequently observed as comorbidities in individuals with hypoxia associated with chronic obstructive pulmonary disease (COPD) (24). Obstructive sleep apnea (OSA), characterized by recurrent episodes of intermittent hypoxia during sleep, is prevalent in approximately 11%–18% of individuals diagnosed with major depressive disorder (25). Indeed, various researchers have delineated differing patterns of effect resulting from hypoxic events on the brain’s neuropathological and cognitive processes. Some describe a diffuse pattern, wherein there is a global deterioration across various brain regions and functions (26). This diffuse effect suggests widespread damage throughout the brain. In contrast, others propose that certain brain regions are affected at different rates, with specific cortical regions known as ‘watershed’ areas being particularly vulnerable (27). These watershed regions rely heavily on cerebral arteries for an efficient and continuous vascular supply. Consequently, they are more susceptible to damage during hypoxic events. Additionally, studies have identified specific brain regions within the temporal lobes, including the hippocampus, as being especially prone to the effects of hypoxia (28–30). These regions are noted for their high metabolic activity and are therefore more sensitive to disruptions in oxygen supply. Damage to the hippocampus, for example, can have profound implications for memory formation and cognitive function. Indeed, some researchers have proposed that the structural and pathophysiological consequences following hypoxia are primarily dependent on the nature and severity of the injury (31). This suggests that the extent of damage and the specific mechanisms of injury play crucial roles in determining the outcomes of hypoxic brain injury. A literature review has indicated that the total duration of unconsciousness following a hypoxic brain injury is closely associated with long-term cognitive prognosis. This suggests that the duration of impaired consciousness serves as an important predictor of cognitive outcomes, with longer periods of unconsciousness generally correlating with poorer cognitive prognosis. Furthermore, scholars have argued that the extent of impairment is directly linked to the site and brain structures affected by the hypoxic event (27). In other words, the specific brain regions and structures that sustain damage during a hypoxic event play a critical role in determining the severity and nature of cognitive deficits experienced by individuals following such an injury.
Clinical studies have shown that individuals with neurotic personality traits have an increased susceptibility to respiratory diseases primarily characterized by hypoxia. A cohort study of older adults found that individuals with high levels of neuroticism had lower peak expiratory flow and were more likely to develop COPD and experience dyspnea (32). In patients with stable COPD, dyspnea scores were correlated with indices of anxiety, depression, and neuroticism (33). Additionally, research indicates that neuroticism, agreeableness, and conscientiousness personality traits significantly influence COPD Assessment Test scores (34). Moreover, the diagnosis of asthma and poor asthma control in adolescents is associated with elevated neuroticism and perceived stress (35). A cohort study of middle-aged adults demonstrated that high neuroticism increases the risk of asthma (36). Another study also indicates that higher neuroticism scores are linked to a greater likelihood of a lifetime asthma diagnosis (37). Furthermore, a seven-year longitudinal study found that neuroticism was predictive of an increased risk of bronchitis (38). It is worth mentioning that there is substantial evidence that nocturnal hypoxemia frequently occurs in conditions such as asthma (39, 40), COPD (39, 41), OSA (42) and bronchitis (43).
The relationship between neuroticism and nocturnal hypoxia can be understood through both autonomic dysfunction and hormonal regulation. Existing research also highlights that neuroticism is associated with autonomic dysfunction (44, 45), particularly through increased sympathetic activity (46, 47). This heightened sympathetic activity can disrupt normal respiratory patterns, with studies indicating interactions between muscle sympathetic nerve activity and hypoxia (48). Additionally, neuroticism is associated with an imbalance between sympathetic and parasympathetic nervous system activity (49, 50). Increased sympathetic activity, coupled with reduced parasympathetic regulation, can lead to peripheral vasoconstriction, which reduces oxygen delivery to tissues. This imbalance may be especially pronounced during sleep, where reduced airway dilation due to sympathetic influence can result in intermittent breathing pauses and hypoxia (51). Moreover, individuals with high levels of neuroticism are more prone to anxiety and panic reactions, especially in quiet, isolated environments at night. These responses can lead to heightened awareness of breathing patterns and may cause alterations in respiratory function, such as shortness of breath or hyperventilation, which in turn can lead to hypoxemia (52). In addition, the connection between neuroticism and nocturnal hypoxia can also be explained through its effects on the hypothalamic-pituitary-adrenal (HPA) axis. Neuroticism is linked to prolonged HPA axis activation (53–55), which leads to elevated cortisol levels. These hormonal changes affect not only metabolic processes but also the central nervous system’s control of respiration (56, 57). This can result in irregular breathing patterns, increasing the risk of nocturnal hypoxia (58, 59).
While substantial evidence exists on the significant associations between personality traits, nocturnal hypoxia, and psychological symptoms, no prior study has investigated the potential mediating role of nocturnal hypoxia in this intricate relationship. Therefore, our study aims to fill this gap and contribute to the existing literature in several meaningful ways. Our primary objective is to examine the hypothesis that nocturnal hypoxia mediates the positive association between personality traits and psychological symptoms in individuals experiencing sleep disturbances. By addressing this gap in knowledge, our study seeks to advance understanding of the complex interplay between personality traits, nocturnal hypoxia, and psychological symptoms, thereby providing valuable insights for clinical practice and further research in this field.
2 Methods
2.1 Participants
We recruited a total of 171 participants aged 18 and above, presenting with sleep complaints (44 males, with a mean age of 57.99 years), from the outpatient or inpatient department of Dalian Seventh People’s Hospital between September 2019 and January 2023. All participants underwent polysomnography (PSG) due to various sleep-related issues, such as sleep disorders, snoring, abnormal behavior during sleep, observed apnea, and other related complaints. General information gathered for each participant included gender, age, marital status, family history of mental disorders, smoking and drinking history, major illnesses, medication use, and body mass index, among others. All procedures involving human participants adhered to the ethical standards set forth by the institutional and/or national research committee and complied with the principles outlined in the 1964 Helsinki Declaration and its subsequent amendments or comparable ethical standards. The study received approval from the ethics committee of Dalian Seventh People’s Hospital, and written informed consent was obtained from all participants or their legal guardians.
2.2 PSG measures
Nocturnal PSG serves as a crucial diagnostic tool for various sleep disorders, allowing for a comprehensive assessment of sleep architecture, respiratory patterns, and hypoxia levels in subjects. PSG enables simultaneous recording of electroencephalogram (EEG), electromyography (EMG), and eye movement, providing detailed insights into sleep quality and respiratory events (60, 61). In our study, participants underwent PSG using a 64-channel PSG system (Compumedics Grael, Australia), adhering to the guidelines outlined by the American Academy of Sleep Medicine. PSG data were meticulously scored to analyze sleep stages and respiratory events. To evaluate hypoxia levels, peripheral capillary oxygen saturation (SpO2) measurements were obtained, including average SpO2, lowest SpO2, and cumulative time spent with oxygen saturation levels (T95, T85) below various thresholds (e.g., <95%, <85%). These measurements were conducted from 22:00 to 06:00 the following day in a controlled environment characterized by darkness and minimal disturbance.
2.3 Mental health status measurements
In our study, we employed the Symptom Checklist-90-Revised (SCL-90-R), specifically utilizing its Chinese version, to assess the mental health status of participants. This self-report questionnaire comprehensively evaluates various dimensions of psychological symptoms, encompassing somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism. Participants were instructed to rate their behaviors, feelings, and thoughts over the preceding week using a 5-point Likert scale, providing a nuanced understanding of their psychological experiences. To enhance the reliability of our assessments, we carefully managed the timing of mental health evaluations relative to overnight PSG administration. Specifically, we restricted the time interval between mental testing and PSG to three days. This precautionary measure aimed to minimize potential fluctuations in mental health status that could confound our analyses. By ensuring consistency in the timing of assessments, we sought to establish a robust foundation for our findings and enhance the validity of our conclusions.
2.4 Personality traits measurements
The Eysenck Personality Questionnaire (EPQ), devised by Hans J. Eysenck, is a self-report scale derived from the Eysenck Personality Inventory (EPI). Rooted in Eysenck’s personality dimension framework, the EPQ evaluates personality traits via factor analysis of questionnaire data. Eysenck identified three core dimensions of personality type through this method: extraversion (E), neuroticism (N), and psychoticism (P). Additionally, the questionnaire incorporates a social desirability scale (L), enhancing its comprehensive assessment of personality traits. Thanks to its brevity, simplicity, and broad applicability, the EPQ has exhibited strong reliability and validity, rendering it a valuable instrument in both psychological research and clinical settings.
2.5 Statistical analysis
Statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA, version 23.0). Descriptive statistics were computed for variables including gender, age, marital status, family history of mental disorders, smoking history, drinking history, major illness, medication use, and BMI. Absolute and relative frequencies were calculated for qualitative variables. The student’s t-test was employed to compare means between two groups, while analysis of variance (ANOVA) was used to compare the means of more than three groups. To assess for a significant indirect effect, a mediation analysis was conducted using SPSS 25.0, examining three pathways: pathway A from the independent variable to the mediator, pathway B from the mediator to the dependent variable, and pathway C from the independent variable to the dependent variable. Variables demonstrating a p-value < 0.05 in the bivariate analysis were included in the path analysis. Statistical significance was set at p < 0.05.
3 Results
3.1 Characteristics of participants
The study comprised a total of 171 participants, with 44 being male and having an average age of 58.84 years (standard deviation ±10.11). Among the participants, the majority were married (91.8%), with 1.8% being divorced, 2.9% single, and 3.6% widowed. Noteworthy findings included 12.3% reporting a family history of mental disorders, 22.8% with a history of hypertension, 9.4% with a history of diabetes, 17% with a history of fatty liver, 12.3% with a history of cerebral infarction or lacunar infarction, 10.5% with a smoking history, 7.6% with a history of alcohol consumption, 8.8% with a history of COPD, 4.1% with a history of asthma, and 18.1% with a history of OSA. Furthermore, 70.8% of participants had used at least one benzodiazepine within a week, while 15.8% had used more than one benzodiazepine during the same timeframe (Table 1).
Table 1. Characteristics of the participants.
In all participants, the mean BMI was 23.06 ± 3.01. The variables T95 and T85 represented the cumulative time of nocturnal hypoxia, with EPQ scores for extraversion (E) averaging 52.10 (± 0.96), neuroticism (N) averaging 57.92 (± 1.57), and psychoticism (P) averaging 52.81 (± 12.18). The SCL-90-R scores reflected the psychological status of the participants across nine dimensions: somatization (2.09 ± 0.72), obsessive compulsive (2.30 ± 0.82), interpersonal sensitivity (1.94 ± 0.74), depression (2.22 ± 0.83), anxiety (2.20 ± 0.88), hostility (1.79 ± 0.72), phobic anxiety (1.75 ± 0.81), paranoid ideation (1.69 ± 0.70), and psychoticism (1.81 ± 0.67) (Table 1).
3.2 Bivariate analysis
The results of bivariate analysis, presented in Tables 2 and 3, revealed significant associations between various factors and psychological symptoms. Participants with a family history of mental disorders exhibited higher scores in somatization (2.34 ± 0.54 vs 2.05 ± 0.73, p < 0.05), obsessive-compulsive (2.52 ± 0.54 vs 2.27 ± 0.85, p < 0.05), and depression (2.57 ± 0.72 vs 2.17 ± 0.84, p < 0.05) compared to those without such a family history. Similarly, participants with a smoking history demonstrated elevated levels of depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism compared to non-smokers (p < 0.05). Likewise, participants with a history of alcohol consumption displayed increased scores in depression, anxiety, hostility, paranoid ideation, and psychoticism compared to those without a history of alcohol consumption (p < 0.05) (Table 2).
Table 2. Bivariate analysis of factors associated with psychological symptoms (somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism).
Table 3. Correlation of continuous variables with psychological symptoms (somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism).
Furthermore, our analysis revealed significant associations between neuroticism (N) and psychoticism (P) with all examined psychological symptoms, encompassing somatization (N: Rho=0.27, p < 0.01; P: Rho=0.40, p < 0.01), obsessive compulsive (N: Rho=0.38, p < 0.01; P: Rho=0.31, p < 0.01), interpersonal sensitivity (N: Rho=0.48, p < 0.01; P: Rho=0.44, p < 0.01), depression (N: Rho=0.44, p < 0.01; P: Rho=0.43, p < 0.01), anxiety (N: Rho=0.039, p < 0.01; P: Rho=0.38, p < 0.01), hostility (N: Rho=0.41, p < 0.01; P: Rho=0.42, p < 0.01), phobic anxiety (N: Rho=0.33, p < 0.01; P: Rho=0.34, p < 0.01), paranoid ideation (N: Rho=0.39, p < 0.01; P: Rho=0.47, p < 0.01), and psychoticism (N: Rho=0.44, p < 0.01; P: Rho=0.49, p < 0.01). Additionally, the cumulative time of nocturnal hypoxia, denoted by T85, exhibited a significant association with phobic anxiety (Rho=0.16, p < 0.05). Additionally, T95 was found to be associated with both age (Rho=0.34, p < 0.01) and BMI (Rho=0.26, p < 0.01). Moreover, T85 demonstrated associations with both BMI (Rho=0.27, p < 0.01) and extraversion (E) personality traits (Rho=0.39, p < 0.01) (Table 3).
3.3 Mediation analysis
The mediation analysis, adjusted for gender, age, marital status, family history of mental disorders, smoking history, drinking history, and BMI, revealed that T85 played a partial mediating role in the association between neuroticism and various psychological symptoms. Specifically, T85 partially mediated the relationship between neuroticism and somatization (c=0.207, c’=0.164, a*b=0.043, proportion of mediation 20.8%), interpersonal sensitivity (c=0.360, c’=0.326, a*b=0.034, proportion of mediation 9.6%), depression (c=0.277, c’=0.234, a*b=0.042, proportion of mediation 15.3%), anxiety (c=0.240, c’=0.199, a*b=0.041, proportion of mediation 16.9%), hostility (c=0.241, c’=0.205, a*b=0.036, proportion of mediation 14.9%), phobic anxiety (c=0.271, c’=0.241, a*b=0.030, proportion of mediation 11.1%), and psychoticism (c=0.298, c’=0.266, a*b=0.032, proportion of mediation 10.8%). Higher scores of neuroticism were significantly associated with increased levels of T85, which, in turn, were associated with higher scores of these psychological symptoms. Additionally, higher scores of neuroticism were directly associated with elevated scores of these symptoms (Figure 1).
Figure 1. The mediating role of T85 in the relationship between neuroticism and psychological symptoms. (A): T85 as a mediator between neuroticism and somatization; (B): T85 as a mediator between neuroticism and interpersonal sensitivity; (C): T85 as a mediator between neuroticism and depression; (D): T85 as a mediator between neuroticism and anxiety; (E): T85 as a mediator between neuroticism and hostility; (F): T85 as a mediator between neuroticism and phobic anxiety; (G): T85 as a mediator between neuroticism and psychoticism; Pathway: (a) Relation between neuroticism and T85; (b) Relation between T85 and psychological symptoms; (c) Total effect of neuroticism on psychological symptoms; (c’) Direct effect of neuroticism on psychological symptoms. Numbers are displayed as regression coefficients (standard error). p<0.05; *p<0.01.
4 Discussion
Regarding the direct effect, our findings revealed that greater psychological symptoms, including somatization, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, and psychoticism, were directly associated with neuroticism. This is consistent with previous research that has also confirmed the link between neuroticism and psychological symptoms (15, 16). Indeed, research has found that neuroticism plays a significant moderating role between allostatic load and mental health during the COVID-19 pandemic (62). This suggests that individuals with higher levels of neuroticism may be more susceptible to the effects of allostatic load on their mental well-being during times of heightened stress and uncertainty, such as a global pandemic. Allostatic load refers to the cumulative physiological burden on the body due to chronic stressors, and individuals with high neuroticism may experience greater difficulty in coping with these stressors, leading to exacerbated mental health outcomes (62). Additionally, other studies have shown that momentary self-regulation is more variable in individuals with higher levels of neuroticism (63). It’s been suggested that neuroticism personality traits can influence physiological reactivity to mental and emotional stressors, potentially increasing psychological stress in various complex situations (64–66). Exposure to pandemic stressors combined with neuroticism has been identified as a risk factor for depressive symptoms, aiding in the identification of individuals at greater risk for adverse psychological responses during the COVID-19 pandemic (67). Some scholars propose that neuroticism serves as an independent etiologically informative risk factor for common mental disorders and can serve as an efficient marker of nonspecific general risk in mental health (68). Moreover, genome-wide association studies have revealed genetic correlations between neuroticism and conditions such as anorexia nervosa, major depressive disorder, and schizophrenia (69). A meta-analysis has further supported associations between neuroticism and anxiety, depression, and non-specific mental distress (65, 70). In conjunction with our findings, these research results collectively underscore the crucial role of neuroticism in understanding mental health outcomes and risk factors for various psychological conditions. Neuroticism emerges as a significant factor influencing how individuals respond to stressors and navigate psychological challenges, particularly during challenging periods like the COVID-19 pandemic.
It is worth mentioning that during the COVID-19 pandemic, the high incidence of hypoxia has further highlighted its role in the development of psychiatric symptoms among neurotic populations. The COVID-19 pandemic has been linked to significant respiratory dysfunctions, particularly in patients with pre-existing conditions. Studies indicate that COVID-19 exacerbates underlying respiratory diseases such as COPD, asthma, and OSA, which are also associated with neuroticism (71–73). In severe cases of COVID-19, the virus can directly impact lung function, often resulting in acute respiratory distress syndrome and subsequent nocturnal hypoxia (74). Additionally, asymptomatic hypoxia is more prevalent in COVID-19 cases and is linked to adverse outcomes and altered mental status (75–77). This is particularly relevant for individuals with neurotic traits, who may be more vulnerable to respiratory complications due to stress-induced physiological changes, including autonomic dysfunction and impaired breathing regulation (35, 78). Moreover, the pandemic has been associated with increased distress, fear, obsessions, and reduced positive mood symptoms. Individuals with neuroticism and autonomic risk factors may be at a heightened risk for developing psychopathology (79). Research has shown that patients with OSA experience approximately an eight-fold greater risk of COVID-19 infection compared to a similar-aged population (80). The relationship between neuroticism and respiratory health during the COVID-19 pandemic suggests that individuals with high neuroticism may face worse outcomes, including increased anxiety and stress, which can further exacerbate respiratory issues such as nocturnal hypoxia. Furthermore, there is evidence that COVID-19-related sleep disturbances and heightened stress can contribute to irregular breathing patterns during sleep, thereby increasing the risk of intermittent nocturnal hypoxia in affected patients (81, 82). In this context, the pandemic underscores the importance of considering both psychological and physiological factors, as the interaction between neuroticism and respiratory health appears especially pertinent during times of heightened stress, such as during COVID-19.
Our mediation analysis confirmed our hypothesis regarding the indirect effect: T85 serves as a mediating variable in the association between neuroticism personality traits and psychological symptoms, including somatization, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, and psychoticism. Specifically, a higher cumulative time of nocturnal hypoxia in individuals with neuroticism personality traits was found to be associated with an increased manifestation of psychological symptoms. This study’s mediation analysis elucidated the interplay among these three variables (neuroticism personality traits, T85, and psychological symptoms) and highlighted the mediator role of nocturnal hypoxia in this association, thereby extending the findings of previous literature. Healthcare professionals may potentially identify individuals at greater risk of developing psychological symptoms by identifying those with heightened levels of nocturnal hypoxia. Early identification and intervention targeting nocturnal hypoxia may, therefore, be beneficial in mitigating the development or progression of psychological symptoms in these individuals.
In addition, the accumulation of hypoxia emerges as a crucial mediating factor, indicating that prolonged hypoxia may indirectly contribute to the exacerbation of psychological symptoms. Hypoxia is intricately linked to various diseases, including chronic kidney disease, lung diseases, and anemia. Our experimental findings suggest that, in the presence of a predisposition toward certain personality traits, the cumulative duration of nocturnal hypoxia may serve as a pivotal mediating factor in the transition to mental illness. Furthermore, a big data survey demonstrates that patients with COPD and current smokers are at an increased risk of developing depression (83). Additionally, research has shown that hypobaric hypoxia exposure induces depression-like behavior in female rats, but not in males (84). Previous studies have shown that the total duration of unconsciousness following a hypoxic brain injury is closely associated with long-term cognitive prognosis. In other words, the duration of consciousness impairment is an important predictor of cognitive outcomes. This is consistent with our research findings. These findings underscore the importance of considering nocturnal hypoxia as a potential mediator in the relationship between personality traits and mental illness, highlighting the need for further research to elucidate the underlying mechanisms and implications for clinical practice.
Over the past two decades, insights from clinical practice and animal experiments have illuminated the intricate role of hypoxic injury in the pathophysiology of mental disorders, driven by diverse neurochemical and neurobiological mechanisms. Despite the conventional assumption of a close correlation between neuronal activity and cerebral blood flow (CBF) (85), hypoxia-induced alterations in CBF exhibit regional variability, with specific brain regions affected, leading to neurocognitive dysfunction (86). Previous studies have underscored the detrimental impact of prolonged hypoxia on dopaminergic and serotonergic functions, thereby heightening susceptibility to psychological disorders (87–89). Additionally, hypoxic conditions have been shown to modulate signaling pathways such as brain-derived neurotrophic factor and Ras homolog gene family member A/Ras homolog-associated kinase in the brain (15, 90), culminating in elevated levels of inflammatory mediators and subsequent cerebral hypoxic damage (91–93). Acute hypoxia prompts the deployment of multiple oxygen sensors by neurons to adapt to physiological changes, whereas chronic hypoxia may induce severe perturbations in synaptic transmission and activate transcription factors regulating oxygen homeostasis (94). The brain’s decompensation response to chronic hypoxia may contribute to the emergence of mental symptoms (16), embodying adaptive mechanisms employed by the brain to cope with prolonged oxygen deficiency. Furthermore, primary necrosis initiated by the underlying event triggers a secondary inflammatory process (95). Furthermore, research has revealed that monoamine oxidase A upregulation induced by chronic intermittent hypoxia plays a significant pathogenic role in oxidative stress, inflammation, and cytokine-responsive indoleamine 2,3-dioxygenase-1 activation, resulting in serotonin depletion and neurodegeneration (96). This may be a multifaceted reason why hypoxia plays a role in mediating the relationship between neuroticism and psychological symptoms.
By specifically examining nocturnal hypoxia, our study both confirms and extends earlier findings regarding its significant role in mental health outcomes. These results provide preliminary insights into new opportunities for reducing psychological distress in individuals experiencing hypoxia. Indeed, our findings suggest that prolonged hypoxia during sleep may contribute to neurotic tendencies in personality and predisposition to mental illness. Recognizing the impact of nocturnal hypoxia enables the development of tailored interventions and strategies aimed at promoting mental well-being and mitigating the risk of psychological disorders among patients with neuroticism personality traits. Incorporating nocturnal hypoxia into clinical assessments and treatment plans of patients with neuroticism personality traits empowers healthcare professionals to address the diverse needs of individuals more effectively, ultimately improving mental health outcomes.
While this study has provided valuable clinically relevant evidence, it is important to acknowledge several limitations. Firstly, our study did not investigate the long-term effects of nocturnal hypoxia. Repeated PSG could offer more precise insights, but it may impose financial constraints and decrease patient compliance. Future research should explore alternative detection methods and indicators to better understand the implications of chronic hypoxia over the long term. Secondly, the cross-sectional design of this study precludes establishing causality between variables. Longitudinal studies would be beneficial in elucidating the temporal relationships between nocturnal hypoxia, neuroticism, and psychological symptoms. Thirdly, due to the scope of our study objectives, we limited the questionnaire items to those directly relevant, in order to streamline administration and reduce participant burden. As a result, we did not consider other potential mediators that are already known in the literature. Lastly, future investigations should delve deeper into the interplay between nocturnal hypoxia, neuroticism, and psychological symptoms. Despite these limitations, this study represents an initial exploration of the relationships between nocturnal hypoxia and mental disorders, offering a fresh perspective and evidence for clinical evaluation and treatment approaches.
5 Conclusion
Nocturnal hypoxia may mediate the association between neuroticism personality traits and psychological symptoms in individuals with sleep disorders. Recognizing the mediating role of nocturnal hypoxia could aid in developing targeted interventions to enhance the psychological well-being of individuals with sleep disorders. Further research is needed to explore the underlying mechanisms and implications for personalized treatment approaches.
Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Ethics statement
The studies involving humans were approved by the ethics committee of Dalian Seventh People’s Hospital. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.
Author contributions
FJ: Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing. JH: Conceptualization, Investigation, Validation, Writing – review & editing. LF: Conceptualization, Investigation, Writing – review & editing. XD: Data curation, Investigation, Methodology, Writing – review & editing. CY: Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing. WZ: Data curation, Investigation, Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The study was supported by Dalian Life and Health Planning Guidance Project and Dalian Medical Science Research Project (2211015).
Acknowledgments
The authors would like to thank all participants. During the preparation of this work the authors used ChatGPT 3.5 in order to spell check and proof-reading assistance. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
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Keywords: nocturnal hypoxia, mediation analysis, neuroticism, psychological symptoms, sleep disorders
Citation: Jiang F, Huang J, Fan L, Dong X, Yang C and Zhou W (2024) Nocturnal hypoxia in patients with sleep disorders: exploring its role as a mediator between neurotic personality traits and psychological symptoms. Front. Psychiatry 15:1442826. doi: 10.3389/fpsyt.2024.1442826
Received: 03 June 2024; Accepted: 11 November 2024;
Published: 06 December 2024.
Edited by:
Jianyu Que, Xiamen Xianyue Hospital, ChinaCopyright © 2024 Jiang, Huang, Fan, Dong, Yang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Fei Jiang, amlhbmdmZWkwMjE0QDE2My5jb20=