Adriana Farcas
Mackenzie Campbell
Charmaine Wong
Felicia Iftene- Providence Care Hospital, Queen’s University, Kingston, ON, Canada
Background: Schizophrenia is a severe, chronic mental disorder that involves disruptions in cognitive processes, emotional responsiveness, and social interactions. Psychotherapeutic and social integration practices have increasingly been added to the pharmacological treatment in an effort to improve the level of functioning and the quality of life of individuals affected by this condition. Befriending, defined as a one-on-one companionship provided by a volunteer who aims to act as an emotionally supportive liaison, is hypothesized to be an effective such intervention, offering support for building and maintaining social relationships in the community. Despite its increase in popularity and acceptance, befriending remains poorly understood and under-researched.
Methods: We performed a systematic search for studies targeting befriending either as an intervention or a controlled condition in studies on schizophrenia. Searches were performed in four databases: APA PsycInfo, Pubmed, Medline and EBSCO. The keywords “schizophrenia,” AND “befriending,” were searched for on all databases.
Results: The search yielded 93 titles and abstracts, of which 18 met the criteria for inclusion. The studies included in this review have all incorporated befriending as an intervention or a controlled condition, as per our search criteria, and aimed at depicting the value and feasibility of this intervention to address social and clinical deficits in individuals with schizophrenia.
Conclusion: The studies selected for this scoping review revealed inconsistent findings regarding the effect of befriending on overall symptoms and the subjective reporting of quality of life in individuals with schizophrenia. This inconsistency may be attributed to differences between the studies and their specific limitations.
Introduction
Schizophrenia is a severe, chronic mental disorder that involves disruptions in cognitive processes, emotional responsiveness, and social interactions. Individuals with schizophrenia tend to exhibit poor social functioning and are characteristically more socially isolated when compared to other groups of people in the general population (1). Psychotherapeutic and social integration practices have increasingly been included in therapeutic guidelines in addition to the pharmacological treatment, to improve quality of life. A recent systematic review of efficacy meta-analyses on psychosocial and behavioral interventions in schizophrenia (2) highlights the most cited ones in the literature: CBT and cognitive based interventions, social skills training, acceptance, and mindfulness based approaches, family interventions, exercise therapy, music therapy, as well as befriending, although no evidence was found in support of befriending as being superior to other interventions. Within this approach, befriending stands as an intervention of interest, still, as it is one of the most easily available approach. It does not involve extensive training nor does it come with associated risks, and it is hypothesized to be an effective intervention for individuals with schizophrenia as it serves as a resource that these patients can utilize in order to better integrate in the community.
Befriending is a one-on-one companionship that is regularly provided by a volunteer who aims to act as an emotionally supportive liaison (3). Although concepts such as mentoring, peer support and friendship are considered related to befriending, and sometimes used interchangeably, there are important distinctions the literature highlights: mentoring aims at achieving specific goals; peer support implies that the provider has lived experience of the condition, while friendship refers to a private, mutual and voluntary exchange between two individuals (4). The befriending interventions are not responsible for targeting particular dilemmas or symptoms nor do they imply deeper, private, mutual connections; rather it is simply a social interaction between patients and volunteers, hence volunteer training is not compulsive (3). The discussed topics are generally of a neutral nature, including possible interests and hobbies of the patient; thus, the volunteer would not challenge any delusions of the patients with schizophrenia and would instead divert the conversation to a different, neutral topic (5). Due to the ease of initiating and low cost involved, this type of intervention, befriending as a type of treatment protocol has the potential to be widely used in all clinical and community settings for patients with schizophrenia.
While befriending may have been exercised between patients and healthcare workers or volunteers for quite some time already, the effects of befriending on individuals with schizophrenia and their symptoms have not received extensive academic attention. In the systematic review on studies occurring before 2009 (6), only one literature source was identified that was at all related to befriending in treating early psychosis, although the onset of schizophrenia occurs at an early, socially vulnerable stage of life. Additionally, befriending was only used as a controlled condition, meaning no study was identified prior to 2009 examining the effect of befriending as an intervention on early psychosis.
In this scoping review, the aim is to investigate the existing literature regarding befriending either as an intervention or a controlled condition in studies on schizophrenia to gather the findings and conclusions on the effect of befriending on patients with this diagnosis and their associated symptoms. In further considering the limitations of these studies, the hope is to also delineate if or how befriending as an intervention is useful in individuals with schizophrenia, as well as to provide directions and considerations for future studies that should be conducted.
Methods
Befriending has only recently begun to gain academic traction as it has been a less utilized, and therefore less studied, intervention style in the past. To ensure the broadest scope allowing for the identification of the greatest number of evidence-based studies, the literature search involved four databases: PubMed, Medline, APA PSYCinfo, and Embase. To be considered eligible for this scoping review, articles must have presented experimental results using befriending either as an intervention or as a controlled condition for individuals with schizophrenia.
On all four of the databases the keywords “befriending” and “schizophrenia” were used with the Boolean operator “AND.” As studies examining befriending as an intervention are fairly limited, the publication dates were set to include “all publications since 2000”. Only articles published in peer-reviewed journals with full text available are included in this scoping review.
The initial PubMed database search returned 21 results, Medline database 18; APA PSYCinfo database 22 and the Embase database search returned 32 results. Following the elimination of duplicate articles, the ones examining the effect of befriending interventions on individuals other than those with schizophrenia, articles examining only interventions other than befriending on individuals with schizophrenia, and other systematic reviews themselves, a total of 18 studies meeting the criteria described above were examined in the present scoping review (see Figure 1). The studies in the current review include: (1) 11 randomized controlled trials; (2) 1 exploratory non-controlled study; (3) 1 prospective, single-blind, randomized controlled trial; (4) 1 parallel, single-blind, randomized controlled trial; (5) 1 parallel, randomized controlled trial; and (6) 1 preliminary controlled/comparative study.
Figure 1. PRISMA flow diagram for befriending studies in patients with schizophrenia.
Results
The studies included in this review have all incorporated befriending as an intervention or a controlled condition, as per our search criteria, and aimed at depicting the value and feasibility of this intervention to address social and clinical deficits in individuals with schizophrenia.
Of the 18 articles selected, 7 are secondary research studies – performing statistical analysis on data from other studies, included here: (9–13) use data from (7), Allot et al. (15), and (8) use data from (18).
Ten of the articles describe randomized controlled studies [(19); 7); (1, 18, 20–25)] and one an exploratory non-controlled study (26).
The population in most of the studies refers to individuals with schizophrenia except for Jackson et al. (18) that refers to individuals with first episode of psychosis and Botero-Rodriguez et al. (26) that includes individuals with bipolar disorders along with individuals with schizophrenia. A summary of main protocol, outcome measures and key findings in each article included can be seen in Table 1.
Table 1. Study and participant characteristics, protocol, outcome measures, and key findings in the selected studies.
Discussions
To adequately compare and contrast results, the aforementioned studies have been divided into two categories: befriending as an intervention and befriending as a controlled condition. It appeared important to indicate the differences between the two set-ups as they involve different modalities of delivery. Befriending as an intervention itself puts greater emphasis on adjusting to client needs, including the time and place to undertake the intervention, which varies depending on the needs and interest of the client. On the other hand, befriending as a controlled condition was conducted at a fixed time and place to minimize the differences in controlled variables. Evidently, the difference in these set-ups contribute to the generation of different results.
A series of limitations of the studies included in this review challenge a straightforward understanding of the value of befriending in the mix of care strategies for individuals with schizophrenia. The small sample size not allowing for results to reach significance level, followed by the wide variety of outcome measurements and the differences in the format of delivery of the befriending interventions may all contribute to the inconsistent findings. In the study by Sikira et al. (25) for example, patients were paired with one volunteer and meetings were conducted in a one-on-one format, whereas in the study by Botero-Rodriguez et al. (26), patients were assigned to a group, with an average of 3.8 attendees in each meeting, based on similarity in interests; in the rest of the studies, although befriending happened in a one-on-one format, it was delivered by highly skilled therapists. These differences in the delivery of befriending raises the question of which is the best format for delivering the intervention as well as whether or not the delivery influences the effect of befriending on specific symptoms or functioning in patients with schizophrenia.
Studies that included befriending as an intervention in their design (1, 21, 25, 26) had consistently found improvements in some of the clinical or social domains assessed, with notable significant differences: (21) found a significant improvement in psychosocial functioning, self-esteem and thought disturbance; participants in the befriending group in Priebe et al. (1) study had significantly more social contacts than those in the group offered information only; Sikira et al. (25) found that the quality of life of participants in the befriending intervention significantly improved both at the end point and 12 months follow-up. Although different outcome measures were involved in these studies, their results come in alignment with the general view in the literature that befriending improves psychological and social functioning by reducing loneliness, allowing individuals to re-gain confidence and connect or re-connect with social sources of support. Of note, also is the fact that only 2 of the studies included in this review used actual volunteers for befriending: Botero-Rodriguez et al. (26) and Sikira et al. (25), the rest of the studies had the befriending delivered by the same therapists providing the main therapeutic intervention (CBT and CBT based approaches). Considering the impact of the clinical background has on the person providing the befriending, the level of expertise becomes an important confounding factor that was overlooked in these studies. When delivered by a health care professional, befriending may present as an intervention focusing on not providing therapeutic elements that would otherwise be provided, and the nature of the relationship is pre-determined by the professional – as opposed to following a natural course. At the same time it is not financially wise to use certified clinicians to perform underqualified work – unjustifiably increasing the cost of delivery.
The condition the befriending was compared to in these studies varied – from art therapy (21), to providing information on social activities only and treatment as usual [(1, 25), respectively], while Botero-Rodriguez et al. (26) explored changes within the same befriending group pre- to post intervention. Historically seen as an intervention aiming to support individuals with low levels of social support, befriending is becoming gradually more accepted and popular, and such, a certain level of expectation can be considered as a confounding factor not always addressed.
When compared to a cognitive type of therapeutic intervention – befriending as a control condition did not appear to fare as well, each study highlighting the superiority of the intervention addressing specific symptoms within a highly specific clinical approach. CBT was used in 4 of the studies included here (7–19), while 3 of the studies used interventions based on a related cognitive therapeutic approach [ACE in (18); TORCH in (24); Feeling Safe Program in (23)]. The common denominator in these interventions refers to the provision of specialized sessions requiring a highly skilled/trained clinician as opposed to the non-specific approach in befriending. Further confirming their findings, the secondary research studies (9–12, 15) highlight particular differences, according to the outcome measurements included. Notably, significant reduction in suicidality in the CBT group, compared to BF was found in the analysis done by Bateman et al. (9). Recent evidence, indicating an association between inflammatory markers and suicidality as well as the use of low doses of buprenorphine further widen the spectrum of avenues in safely addressing it (27, 28). The importance of exploring the most effective approaches in this regard remain of utmost importance.
Statistically significant differences in anxiety improvement in the CBT group at follow-up was found by Naeem et al. (11) concluding that CBT has an antipsychotic as well as anxiolytic effect, persisting after the therapy stopped.
Of particular interest, in the 5-year follow-up to Sensky et al. (7) study, Turkington et al. (5) found that although both groups (CBT and BF) showed an improvement in the PANSS positive subscale, only the CBT group showed a significant difference over time in the total score of the PANSS as well as quality of life, concluding that CBT is superior to befriending in reducing psychotic symptoms. As expected, these findings confirm the extensive literature highlighting the effectiveness of CBT in psychosis, especially in reducing positive symptoms (29). At the same time these findings acknowledge the benefits an intervention like befriending can provide, considering it was found to have similar acceptability compared to intervention groups and a high level of satisfaction reported by individuals in befriending groups (24). Also, the advantages of befriending as a control condition are not maximized as it loses its flexibility as an intervention due to its delivery at a fixed time and place to minimize the differences in the controlled variables. However, comparison between the studies is difficult as they adopted different scales to measure the same symptoms.
Outcome measures varied greatly – from clinical ones – focusing on symptom improvement, like BPRS, CPRS, PANSS, PSYRATS, SANS, and CGI, to more diverse ones focusing on quality of life, use of time, social functioning, client satisfaction and acceptance. There were also differences in the clinical populations addressed (first episode psychosis, schizophrenia, bipolar disorder), as well as duration and frequency of the intervention.
Although highly recommended by clinical practice guidelines, psychotherapeutic interventions such as CBT for psychosis require lengthy therapist training and prove difficult to be delivered on a large scale within mental health services. Continuing efforts are needed to explore supportive interventions that allow for social engagement and acceptance for this stigmatized population segment, in the context of a comprehensive socio-psychopharmacological approach.
Conclusion
Even though a limited number of researchers focused on the effects of befriending as an intervention in schizophrenia, all 4 studies included had consistently found improvements in some of the clinical or social domains. Although different outcome measures were involved, their results confirm that befriending improves psychosocial and social functioning.
One of the main challenges of the current review was the use of different protocols and outcome measures in the selected studies on befriending as an intervention. A notable limitation we found was the apparent misuse of resources in delivering the befriending, raising the question of appropriateness in delineating what befriending is, as well as its cost-effectiveness.
When delivered by a healthcare professional, befriending may present as an intervention focusing on not providing therapeutic elements that would otherwise be provided, and the nature of the relationship becomes pre-determined by the professional – as opposed to following a natural course. At the same time, the use of certified clinicians to perform underqualified work unjustifiably increases the cost of delivery.
As expected, in studies where befriending was a control condition, results were superior for the specialized interventions condition (CBT and cognitive-based interventions) but they do not detract from the importance of befriending as evidenced by a generally positive acceptance and improvements noted during the intervention.
Although the clinical effects rarely reached significance or withstood the test of time by comparison with established psychotherapeutic interventions, befriending was identified as providing an opportunity for increased social interactions and the development of healthy social relationships, suggesting that it may be considered a complementary or supplementary intervention for patients with schizophrenia, especially when CBT is not readily available.
Further directions
Further directions pertain to: larger sample size studies targeting befriending in schizophrenia with well-defined protocols, longer follow-ups (to determine the timing and frequency of maintenance sessions), using the most relevant clinical outcome measures (PANSS, QoL, third party/collateral information scales). Based on results from follow-ups we could design possible intervention protocols that include well-timed maintenance sessions. A possible model of maintenance session could be based on the protocol used in (26) study and include a progression of delivery of the intervention from one-on-one to a small group form. These protocols would be easy to implement in all clinical and community study, as well as cost effective, provided that the intervention is not performed by highly trained clinicians. A next step in this regard may involve the development of a minimal yet necessary training curriculum for volunteers. This would ensure volunteers are not to interfere with or challenge problematic symptoms, while at the same time allow them to interact with patients in a non-judgmental, accepting and hope-promoting manner.
An avenue not explored in the literature is the use of befriending as a pre-intervention tool, preparing patients for accepted interventions like CBT. The interactions with a volunteer in the time leading to the clinical intervention, would open the door to the therapeutic engagement essential for therapeutic change. In this context, adequate resources would be used for appropriate outcomes and ensure a more comprehensive and effective approach.
Author contributions
All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.
Funding
This work was supported by Providence Care Innovation Grant 2019: “Innovative pathways to impactful treatment of chronic schizophrenia: disrupting the status-quo moving toward biological-driven, combined pharmacological, and non-pharmacological therapeutic approaches to define markers of therapeutic improvement in cognitive behavioral therapy for psychosis promoted recovery”.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1. Priebe, S, Chevalier, A, Hamborg, T, Golden, E, King, M, and Pistrang, N. Effectiveness of a volunteer befriending programme for patients with schizophrenia: randomised controlled trial. Br J Psychiatry. (2020) 217:477–3. doi: 10.1192/bjp.2019.42
2. Cella, M, Roberts, S, Pillny, M, Riehle, M, O’Donoghue, B, Lyne, J, et al. Psychosocial and bhavioural interventions for the negative symptoms of schizophrenia: a systematic review of efficacy meta-analyses. Br J Psychiatry. (2023):1–11. doi: 10.1192/bjp.2023.21
3. Siette, J, Cassidy, M, and Priebe, S. Effectiveness of befriending interventions: a systematic review and meta-analysis. BMJ Open. (2017) 7:e014304. doi: 10.1136/bmjopen-2016-014304
4. Balaam, MC. A concept analysis of befriending. Journal of advanced nursing. (2015) 71:24–34. doi: 10.1111/jan.12553
5. Turkington, D, Spencer, H, Lebert, L, and Dudley, R. Befriending: Active Placebo or Effective Psychotherapy? British journal of psychiatry. (2017) 211:5–6. doi: 10.1192/bjp.bp.116.197467
6. Marshall, M, and Rathbone, J. Early intervention for psychosis. The Cochrane database of systematic reviews. (2011) 6:CD004718. doi: 10.1002/14651858.CD004718.pub3
7. Sensky, T, Turkington, D, Kingdon, D, Scott, JL, Scott, J, Siddle, R, et al. A randomized controlled trial of cognitive-behavioral therapy for persistent symptoms in schizophrenia resistant to medication. Archives of general psychiatry. (2000) 57:165–72. doi: 10.1001/archpsyc.57.2.165
8. Bendall, S, Jackson, HJ, Killackey, E, Allott, K, Johnson, T, Harrigan, S, et al. The credibility and acceptability of befriending as a control therapy in a randomized controlled trial of cognitive behaviour therapy for acute first episode psychosis. Behavioural and Cognitive Psychotherapy. (2006) 34:277–91. doi: 10.1017/S1352465806002815
9. Bateman, K, Hansen, LK, Turkington, D, and Kingdon, D. Cognitive behavioral therapy reduces suicidal ideation in schizophrenia: results from a randomized controlled trial. Suicide Life Threat Behav. (2007) 37:284–10. doi: 10.1521/suli.2007.37.3.284
10. Milne, D, Wharton, S, James, I, and Turkington, D. Befriending versus CBT for schizophrenia: a convergent and divergent Fidelity check. Behav Cogn Psychother. (2005) 34:25–30. doi: 10.1017/s1352465805002456
11. Naeem, F, Kingdon, D, and Turkington, D. Cognitive behaviour therapy for schizophrenia: relationship between anxiety symptoms and therapy. Br J Med Psychol. (2006) 79:153–4. doi: 10.1348/147608305x91538
12. Samarasekera, N, Kingdon, D, Siddle, R, O’Carroll, M, Scott, JF, Sensky, T, et al. Befriending patients with medication-resistant schizophrenia: can psychotic symptoms predict treatment response? Br J Med Psychol. (2007) 80:97–6. doi: 10.1348/147608306x108998
13. Turkington, D, Sensky, T, Scott, J, Barnes, TRE, Nur, U, Siddle, R, et al. A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: a five-year follow-up. Schizophr Res. (2008) 98:1–7. doi: 10.1016/j.schres.2007.09.026
14. Milne, D, and Netherwood, P. Seeking social support: an observational instrumental and illustrative analysis. British Association for Behavioural and Cognitive. Psychotherapies. (1997)
15. Allott, K, Alvarez-Jimenez, M, Killackey, E, Bendall, S, McGorry, PD, and Jackson, HJ. Patient predictors of symptom and functional outcome following cognitive behaviour therapy or befriending in first-episode psychosis. Schizophr Res. (2011) 132:125–10. doi: 10.1016/j.schres.2011.08.011
16. Turkington, D, Kingdon, D, and Turner, T, Insight into Schizophrenia Research Group. Effectiveness of a brief cognitive-behavioural therapy intervention in the treatment of schizophrenia. The British journal of psychiatry: the journal of mental science, (2002) 180:523–527. https://doi.org/10.1192/bjp.180.6.523
17. Turkington, D, Spencer, H, Lebert, L, and Dudley, R. Befriending: Active Placebo or Effective Psychotherapy? British journal of psychiatry. (2017) 211:5–6. doi: 10.1192/bjp.bp.116.197467
18. Jackson, HJ, McGorry, PD, Killackey, E, Bendall, S, Allott, K, Dudgeon, P, et al. Acute-phase and 1-year follow-up results of a randomized controlled trial of CBT versus befriending for first-episode psychosis: the ACE project. Psychol Med. (2008) 38:725–5. doi: 10.1017/s0033291707002061
19. Turkington, D, and Kingdon, D. Cognitive–behavioural techniques for general psychiatrists in the management of patients with psychoses. Br J Psychiatry. (2000) 177:101–6. doi: 10.1192/bjp.177.2.101
20. Barretto, EM, Kayo, M, Avrichir, BS, Reis, AD, Camargo, ME, Napolitano, IC, et al. A preliminary controlled trial of cognitive behavioral therapy in clozapine-resistant schizophrenia. J Nerv Ment Dis. (2009) 197:865–8. doi: 10.1097/nmd.0b013e3181be7422
21. Bozzatello, P, Bellino, S, De Marzi, G, Macrì, A, Piterà, R, Montemagni, C, et al. Effectiveness of psychosocial treatments on symptoms and functional domains in schizophrenia spectrum disorders: a prospective study in a real-world setting. Disabil Rehabil. (2019) 41:2799–06. doi: 10.1080/09638288.2018.1480666
22. Dark, F, Scott, J, Baker, AJ, Parker, SC, Gordon, A, Newman, E, et al. Randomized controlled trial of social cognition and interaction training compared to befriending group. Br J Clin Psychol. (2020) 59:384–2. doi: 10.1111/bjc.12252
23. Freeman, D, Emsley, R, Diamond, R, Collett, N, Bold, E, Chadwick, E, et al. Comparison of a theoretically driven cognitive therapy (the feeling safe Programme) with befriending for the treatment of persistent persecutory delusions: a parallel, single-blind, randomised controlled trial. Lancet Psychiatry. (2021) 8:696–7. doi: 10.1016/s2215-0366(21)00158-9
24. Shawyer, F, Farhall, J, Mackinnon, A, Trauer, T, Sims, E, Ratcliff, K, et al. A randomised controlled trial of acceptance-based cognitive behavioural therapy for command hallucinations in psychotic disorders. Behav Res Ther. (2012) 50:110–1. doi: 10.1016/j.brat.2011.11.007
25. Sikira, H, Jankovic, SM, Slatina, M, Muhić, M, Sajun, SZ, Priebe, S, et al. The effectiveness of volunteer befriending for improving the quality of life of patients with schizophrenia in Bosnia and Herzegovina – an exploratory randomised controlled trial. Epidemiol Psychiatr Sci. (2021) 30:e48. doi: 10.1017/s2045796021000330
26. Botero-Rodríguez, F, Hernández, MV, Uribe-Restrepo, JM, Cabariqe, C, Fung, C, Priebe, S, et al. Experiences and outcomes of group volunteer befriending with patients with severe mental illness: an exploratory mixed-methods study in Colombia. BMC Psychiatry. (2021) 21:239. doi: 10.1186/s12888-021-03232-z
27. Serafini, G, Adavastro, G, Canepa, G, De Berardis, D, Valchera, A, Pompili, M, et al. The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review. International journal of molecular sciences. (2018) 19:2410. doi: 10.3390/ijms19082410
28. Serafini, G, Parisi, VM, Aguglia, A, Amerio, A, Sampogna, G, Fiorillo, A, et al. A Specific Inflammatory Profile Underlying Suicide Risk? Systematic Review of the Main Literature Findings. International journal of environmental research and public health. (2020) 17:2393. doi: 10.3390/ijerph17072393
29. Zimmermann, G, Favrod, J, Trieu, V, and Pomini, V. The effect of cognitive behavioral treatment on the positive symptoms of schizophrenia spectrum disorders: a meta-analysis. Schizophr Res. (2005) 77:1–9. doi: 10.1016/j.schres.2005.02.018
30. Hu, J, Zhang, J, Hu, L, Yu, H, and Xu, J. Art therapy: a complementary treatment for mental disorders. Front Psychol. (2021) 12:686005. doi: 10.3389/fpsyg.2021.686005
Keywords: befriending, schizophrenia, CBT, psychosocial, psychiatry
Citation: Farcas A, Campbell M, Wong C and Iftene F (2023) Is befriending a valuable intervention in schizophrenia? A scoping review. Front. Psychiatry. 14:1189772. doi: 10.3389/fpsyt.2023.1189772
Edited by:
Massimo Tusconi, University of Cagliari, ItalyReviewed by:
Gianluca Serafini, San Martino Hospital (IRCCS), ItalyElisabetta C. del Re, Harvard Medical School, United States
Copyright © 2023 Farcas, Campbell, Wong and Iftene. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Adriana Farcas, NmFtZkBxdWVlbnN1LmNh