This article is a correction to:
Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations
Jiajia Yang1
Mariana A. Argenziano2
Mariana Burgos Angulo1
Alexander Bertalovitz2
Maliheh Najari Beidokhti2Thomas V. McDonald1,2*- 1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, United States
- 2Heart Institute, Department of Medicine (Division of Cardiovascular Sciences), Morsani College of Medicine, University of South Florida, Tampa, FL, United States
A Corrigendum on
Phenotypic variability in iPSC-induced cardiomyocytes and cardiac fibroblasts carrying diverse LMNA mutations
by Yang, J., Argenziano, M. A., Burgos Angulo, M., Bertalovitz, A., Beidokhti, M. N., McDonald, T. V. Front Physiol. (2021). 12:778982. doi: 10.3389/fphys.2021.778982
In the published article, there was an error in Figure 1 as published. In panel B, ALP staining pictures for R335Q and R377H were inadvertently mislabeled, which needs to be replaced. R335Q shows overlap with M1I, and R377H shows overlap with R541C. The corrected Figure 1 appears below.
FIGURE 1
FIGURE 1. Differentiation and characterization of induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iCMs) and cardiac fibroblasts (iCFs). (A) Sanger sequencing validates the presence of the individual mutation. (B) Representative staining of iPSCs expressing pluripotency markers SOX2 (green) and TRA-1-60 (red), SSEA4 (green), OCT4 (red), and alkaline phosphatase. Nuclei were stained with DAPI (blue). (C) Schematic of cardiac differentiation using STEMdiff™ Cardiomyocyte Differentiation kit. (D) Immunostaining of cardiac troponin T positive cardiomyocytes. (E) Workflow to induce cardiac fibroblasts using small molecule-based protocols. (F) Immunostaining of cardiac fibroblast specific marker, vimentin. Scale bar, 100 μm.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: LMNA, dilated cardiomyopathy, induced pluripotent stem cell, cardiomyocytes, cardiac fibroblasts, connexin 43
Citation: Yang J, Argenziano MA, Burgos Angulo M, Bertalovitz A, Beidokhti MN and McDonald TV (2022) Corrigendum: Phenotypic variability in iPSC-induced cardiomyocytes and cardiac fibroblasts carrying diverse LMNA mutations. Front. Physiol. 13:974151. doi: 10.3389/fphys.2022.974151
Received: 20 June 2022; Accepted: 26 July 2022;
Published: 31 August 2022.
Edited and reviewed by:
Xianming Lin, New York University, United StatesCopyright © 2022 Yang, Argenziano, Burgos Angulo, Bertalovitz, Beidokhti and McDonald. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Thomas V. McDonald, thomasmcdonald@usf.edu