Kangkang Zhi
Dongze Zhang
Xiaojing Liu
Wang Han-Jun- 1Department of Vascular and Endovascular Surgery, Changzheng Hospital, Navy Medical University, Shanghai, China
- 2Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, United States
- 3Laboratory of Cardiovascular Diseases and Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China
- 4Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, United States
Editorial on the Research Topic
Metabolism and Vascular Diseases
Vascular disease is now the leading cause of death worldwide, with cardiovascular and cerebrovascular diseases being the main contributors (Andersson and Vasan, 2018; Doria and Forgacs, 2019). However, its pathological mechanism is not definite yet. Currently, various kinds of vascular diseases are supposed to be related to metabolic disturbance (Gao et al., 2020; Marini et al., 2020). Generally, specific vascular disease indicates a disorder in the whole circulatory system (Guľašová et al., 2020; Lorenzon Dos Santos et al., 2020). The systemic metabolic disturbance would result in various kinds of pathologic changes in the circulatory system and undermine vascular homeostasis, involve atherosclerosis, vascular remodeling, etc (Huo et al., 2018; Katakami, 2018; Neeland et al., 2019). Meanwhile, cellular metabolism makes a strong bond with the local vascular lesion, like atheromatosis, endothelium injury, etc (Tabas and Bornfeldt, 2020; Wu et al., 2021). However, the metabolic balance would also be affected by local vascular cells’ physiological regulation, vascular development, and hemodynamics (Smith and Ainslie, 2017; Yang et al., 2020). The characterization of metabolic disturbance and related vascular diseases involves many events and complicated connections, which leave quite a lot of gaps in the field to be further studied. This Topic aimed to cover promising and novel research trends in metabolism and related vascular diseases. Several papers which include Basic or Clinical Medical Research and Review from excellent researchers in multiple fields have been collected to date.
As the dominating part of this Topic, papers of basic research that we primarily collected have revealed some interesting relationships between metabolic abnormalities and vascular diseases. The paper by Yu et al. attempted to illustrate the association between plasma metabolic profiles and cerebral collateral circulation in patients with acute ischemic stroke (AIS). They found that the sphingosine-1-phosphate (S1P) level in plasma showed significant positive correlation with good collateral circulation and which might be a potential diagnostic biomarker for predicting collateral circulation status in patients with AIS. The paper by Xue et al. focused on excavating the potential biomarkers in lacrimal diabetic angiopathy and its potential mechanism. Hub genes App, F5, Fgg, and Gas6 related to the regulation of circulation and coagulation were identified. Meanwhile, certain small molecular compounds were considered that might reverse the altered differentially expressed genes. This study might empower the novel potential targets to treat lacrimal angiopathy and other diabetes-related diseases. The paper by Fan et al. found that myricanol could inhibit proliferation and migration of vascular smooth muscle cells (VSMCs) induced by platelet-derived growth factor-BB by suppressing the platelet-derived growth factor receptor-β and NF-kB p65 translocation. Furthermore, myricanol was found suppressing the intimal hyperplasia in mice with carotid stenosis. The paper by da Costa et al. found the events that HFD-fed leading decreased Nrf2 nuclear accumulation, decreased mRNA expression and activity of Nrf2-regulated enzymes (catalase, heme oxygenase-1, peroxiredoxin and thioredoxin) were prevented in castrated mice. The study indicate that testosterone would downregulate Nrf2, leading to oxidative stress and vascular dysfunction in HFD-fed obese mice.
However, papers of clinical research presented in this Topic have significant discoveries as well. The paper by Hu et al. showed that there was no significant correlation between increased serum uric acid levels and the risk of first stroke in the Chinese adults with hypertension. Meanwhile, risk of the first stroke in patients with hyperuricemia less than 60 years old was significantly higher than control. The paper by Yu et al. was based on bioinformatic analysis of metabolomic and proteomic to reveal that the dysregulation of glutamate and glycine metabolism, upregulated glycolysis and fatty acid synthesis in the endothelial progenitor cells that treated with the oscillatory shear stress.
Meanwhile, the Review paper by Ning et al. with creative perspective summarized the potential mechanism underlying metabolic perturbation that type 2 diabetes mellitus (DM) affect the hypertension (HTN), what may be involved in the metabolism of insulin and angiotensin II, sympathetic nervous system as well as the energy reprogramming.
Author Contributions
This Editorial was prepared jointly by DZ, XL and WH-J.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Andersson C., Vasan R. S. (2018). Epidemiology of Cardiovascular Disease in Young Individuals. Nat. Rev. Cardiol. 15 (4), 230–240. doi:10.1038/nrcardio.2017.154
Doria J. W., Forgacs P. B. (2019). Incidence, Implications, and Management of Seizures Following Ischemic and Hemorrhagic Stroke. Curr. Neurol. Neurosci. Rep. 19 (7), 37. doi:10.1007/s11910-019-0957-4
Gao M., Lv J., Yu C., Guo Y., Bian Z., Yang R., et al. (2020). Metabolically Healthy Obesity, Transition to Unhealthy Metabolic Status, and Vascular Disease in Chinese Adults: A Cohort Study. Plos Med. 17 (10), e1003351. doi:10.1371/journal.pmed.1003351
Guľašová Z., Guerreiro S. G., Link R., Soares R., Tomečková V. (2020). Tackling Endothelium Remodeling in Cardiovascular Disease. J. Cel Biochem 121 (2), 938–945. doi:10.1002/jcb.29379
Huo Y., Wu X., Ding J., Geng Y., Qiao W., Ge A., et al. (2018). Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance. PPAR Res. 2018, 6738703. doi:10.1155/2018/6738703
Katakami N. (2018). Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus. Jat 25 (1), 27–39. doi:10.5551/jat.rv17014
Lorenzon Dos Santos J., Schaan de Quadros A., Weschenfelder C., Bueno Garofallo S., Marcadenti A. (2020). Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease. Nutrients 12 (3), 682. doi:10.3390/nu12030682
Marini S., Merino J., Montgomery B. E., Malik R., Sudlow C. L., Dichgans M., et al. (2020). Mendelian Randomization Study of Obesity and Cerebrovascular Disease. Ann. Neurol. 87 (4), 516–524. doi:10.1002/ana.25686
Neeland I. J., Ross R., Després J.-P., Matsuzawa Y., Yamashita S., Shai I., et al. (2019). Visceral and Ectopic Fat, Atherosclerosis, and Cardiometabolic Disease: a Position Statement. Lancet Diabetes Endocrinol. 7 (9), 715–725. doi:10.1016/s2213-8587(19)30084-1
Smith K. J., Ainslie P. N. (2017). Regulation of Cerebral Blood Flow and Metabolism during Exercise. Exp. Physiol. 102 (11), 1356–1371. doi:10.1113/ep086249
Tabas I., Bornfeldt K. E. (2020). Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis. Circ. Res. 126 (9), 1209–1227. doi:10.1161/circresaha.119.315939
Wu D., Harrison D. L., Szasz T., Yeh C.-F., Shentu T.-P., Meliton A., et al. (2021). Single-cell Metabolic Imaging Reveals a SLC2A3-dependent Glycolytic Burst in Motile Endothelial Cells. Nat. Metab. 3 (5), 714–727. doi:10.1038/s42255-021-00390-y
Keywords: metabolism, vascular diseases, editoral, basic research, clinical researc
Citation: Zhi K, Zhang D, Liu X and Han-Jun W (2022) Editorial: Metabolism and Vascular Diseases. Front. Physiol. 13:888676. doi: 10.3389/fphys.2022.888676
Received: 03 March 2022; Accepted: 18 March 2022;
Published: 25 April 2022.
Edited and reviewed by:
Gerald A. Meininger, University of Missouri, United StatesCopyright © 2022 Zhi, Zhang, Liu and Han-Jun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Kangkang Zhi, a2FuZ2thbmdfemhpQDE2My5jb20=