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CORRECTION article

Front. Physiol., 28 May 2021
Sec. Vascular Physiology
Volume 12 - 2021 | https://doi.org/10.3389/fphys.2021.690189

Corrigendum: Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019

This article is a correction to:

  1. Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019

    1. Read original article
\nFrancesco Moccia Francesco Moccia1*Sharon Negri&#x;Sharon Negri1†Pawan Faris&#x;Pawan Faris1†Angelica PernaAngelica Perna2Antonio De LucaAntonio De Luca3Teresa SodaTeresa Soda4Roberto Berra-Romani Roberto Berra-Romani5*Germano Guerra Germano Guerra2*
  • 1Laboratory of General Physiology, Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy
  • 2Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, Campobasso, Italy
  • 3Section of Human Anatomy, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • 4Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
  • 5School of Medicine, Department of Biomedicine, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico

A Corrigendum on
Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019

by Moccia, F., Negri, S., Faris, P., Perna, A., De Luca, A., Soda, T., et al. (2021). Front. Physiol. 12:629119. doi: 10.3389/fphys.2021.629119

An author name was incorrectly spelled as Roberto-Berra Romani. The correct spelling is Roberto Berra-Romani.

In the original article Penny et al. (2019) was not cited in the article. The citation has now been inserted in “4. TPCs mediate entry and trafficking of viruses in host cells” and should read:

A recent screening campaign confirmed that TPC2 activation regulates EBOV entry in host cells. Measurement of PI(3,5)P2-evoked lysosomal currents, NAADP-induced Ca2+ release and single-channel activity, revealed that FDA-approved dopamine antagonists, such as pimozide and fluphenazine, and selective estrogen receptor modulators, such as clomiphene and raloxifene, were also able to target TPC2 by plugging the channel pore (Penny et al., 2019). Furthermore, these novel inhibitors of TPC2 effectively reduced EBOV infection in vitro (Penny et al., 2019).

In the original article, there was an error. The assertion “Subsequently, the same group demonstrated that TPC2 also regulates MERS-CoV infectivity” is not correct as these findings were obtained by two different groups.

A correction has been made to “4. TPCs mediate entry and trafficking of viruses in host cells”:

Subsequently, TPC2 was found to also regulate MERS-CoV infectivity.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

References

Penny, C. J., Vassileva, K., Jha, A., Yuan, Y., Chee, X., Yates, E., et al. (2019). Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers. Biochim. Biophys. Acta Mol. Cell Res. 1866, 1151–1161. doi: 10.1016/j.bbamcr.2018.10.022

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: SARS-CoV-2, COVID-19, cardiovascular system, two-pore channels, PI(3,5)P2, endolysosomal Ca2+ signaling, NAADP

Citation: Moccia F, Negri S, Faris P, Perna A, De Luca A, Soda T, Berra-Romani R and Guerra G (2021) Corrigendum: Targeting Endolysosomal Two-Pore Channels to Treat Cardiovascular Disorders in the Novel COronaVIrus Disease 2019. Front. Physiol. 12:690189. doi: 10.3389/fphys.2021.690189

Received: 02 April 2021; Accepted: 28 April 2021;
Published: 28 May 2021.

Approved by:

Frontiers Editorial Office, Frontiers Media SA, Switzerland

Copyright © 2021 Moccia, Negri, Faris, Perna, De Luca, Soda, Berra-Romani and Guerra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Francesco Moccia, francesco.moccia@unipv.it; Roberto Berra-Romani, rberra001@hotmail.com; Germano Guerra, germano.guerra@unimol.it

†These authors have contributed equally to this work

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