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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1511627
This article is part of the Research Topic Drug Discovery in Cancer Research: Success Stories and Open Challenges View all 23 articles

Synthesis, Characterization, and Computational Evaluation of Some Synthesized Xanthone Derivatives: Focus on Kinase Target Network and Biomedical Properties

Provisionally accepted
Wisam Taher Muslim Wisam Taher Muslim 1*Layth Jasim Mohammed Layth Jasim Mohammed 2Munaf M Naji Munaf M Naji 1*ISAAC KARIMI ISAAC KARIMI 3*Matheel D. Al-Sabti Matheel D. Al-Sabti 4*Majid Jabir Majid Jabir 5*Mazin A. A. Najm Mazin A. A. Najm 6*Helgi B. Schiöth Helgi B. Schiöth 7*
  • 1 University of Kufa, Kufa, Najaf, Iraq
  • 2 Babylon university, Babylon, Iraq
  • 3 Faculty of Sciences, Razi University, Kermanshah, Kerman, Iran
  • 4 Uruk University, Baghda, Iraq
  • 5 University of Technology, Iraq, Baghdad, Baghdad, Iraq
  • 6 Mazaya University College, Dhi-Qar, Iraq
  • 7 Uppsala University, Uppsala, Uppsala, Sweden

The final, formatted version of the article will be published soon.

     Xanthone derivatives possess numerous significant properties with biomedical applications. Four xanthone derivatives were synthesized from xanthydrol using dithiolan and thiazol. All stable xanthone derivatives were characterized using TLC and FTRI, and they were stable. Ligands did not express any violations to the Lipinski (Pfizer) filter for drug-likeness. Major targets of xanthone derivatives were subsets of the kinase family.  Among synthesized derivatives, L9 expressed promiscuous potential in target binding.

    Keywords: xanthone, Total synthesis, Xanthan, admet, molecular docking, Network analysis, Target fishing

    Received: 15 Oct 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Muslim, Mohammed, Naji, KARIMI, Al-Sabti, Jabir, Najm and Schiöth. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wisam Taher Muslim, University of Kufa, Kufa, Najaf, Iraq
    Munaf M Naji, University of Kufa, Kufa, Najaf, Iraq
    ISAAC KARIMI, Faculty of Sciences, Razi University, Kermanshah, Kerman, Iran
    Matheel D. Al-Sabti, Uruk University, Baghda, Iraq
    Majid Jabir, University of Technology, Iraq, Baghdad, Baghdad, Iraq
    Mazin A. A. Najm, Mazaya University College, Dhi-Qar, Iraq
    Helgi B. Schiöth, Uppsala University, Uppsala, 753 12, Uppsala, Sweden

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.