Skip to main content

MINI REVIEW article

Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1510806
This article is part of the Research Topic Therapeutic Advances in Lung Cancer and Chronic Inflammatory Lung Disease View all 19 articles

Nanobodies: A Promising Strategy for Asthma Therapy

Provisionally accepted
Baraa Khalid Al-Sheakly Baraa Khalid Al-Sheakly 1Fatemeh Saheb Sharif-Askari Fatemeh Saheb Sharif-Askari 1Narjes Saheb Sharif-Askari Narjes Saheb Sharif-Askari 1Jennifer Elisabeth Hundt Jennifer Elisabeth Hundt 2Rabih Halwani Rabih Halwani 1*
  • 1 University of Sharjah, Sharjah, United Arab Emirates
  • 2 University of Lübeck, Lübeck, Schleswig-Holstein, Germany

The final, formatted version of the article will be published soon.

    Asthma is a chronic inflammatory disease of the airways characterized by bronchoconstriction, airway hyperresponsiveness, and mucus production. The pathophysiology of asthma involves a complex interplay of immune cells and mediators, including cytokines, chemokines, and other inflammatory molecules. Despite advances in asthma management, many patients continue to experience symptoms due to the limitations of current therapies. Monoclonal antibodies (mAbs) targeting specific inflammatory mediators have improved treatment outcomes for some patients, but challenges such as poor tissue penetration and high costs remain. Nanobodies (Nbs), a novel class of single-domain antibodies, offer a promising alternative due to their small size, stability, and potential for enhanced tissue penetration. This review discusses the key mediators involved in asthma, challenges in current treatments, and the potential of Nbs as a new therapeutic strategy. We also explore current studies and innovations in nanobody technology.

    Keywords: Asthma, cytokine, inflammatory mediators, monoclonal antibodies, nanobodies (Nbs)

    Received: 13 Oct 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Al-Sheakly, Saheb Sharif-Askari, Saheb Sharif-Askari, Hundt and Halwani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rabih Halwani, University of Sharjah, Sharjah, United Arab Emirates

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.