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ORIGINAL RESEARCH article

Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1498734
This article is part of the Research Topic Terrestrial and Marine Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope - Volume II View all 7 articles

A study to assess the pharmacological agent potential of gold nanoparticles and their effects on human cancer cells and hospital pathogens using in vitro methods Potential of gold nanoparticles as pharmacological agents due to their in vitro antimicrobial and anticancer effects on human cancer cells and hospital pathogens

Provisionally accepted
Ayşe Baran Ayşe Baran *
  • Mardin Artuklu University, Mardin, Türkiye

The final, formatted version of the article will be published soon.

    Interest in metal nanoparticles synthesised using green methods is growing steadily. Metal nanoparticles can be synthesised inexpensively and effortlessly using extracts derived from different plants and their diverse components. Gold nanoparticles (Au NPs) were rapidly synthesised from Broccoli (Brassica oleracea L.) agricultural waste using a novel, costeffective, and eco-friendly method in this work. Analysed data from various techniques including UV-vi, TEM, FESEM, XRD, AFM, FTIR, TGA-DT, EDX, and DLS to assess the properties of the synthesised Au NPs. The characterisation data revealed that the Au NPs had a peak absorbance at 553.10 nm, a surface charge of -19.7 mV, an average hydrodynamic size of 78.75 nm, a monodisperse spherical shape, and were found to be stable. The inhibitory effects of gold nanoparticlesAu NPs with these properties on hospital pathogens and human cancer cells were evaluated by microdilution, disk diffusion and MTT techniquesAs a result of the findings, it was determined that Au NPs have antibacterial, antifungal and anticancer potential as pharmacological agents under in vitro conditions.. As a result of the studies conducted on the potential of Au NPs as pharmacological agents, it was determined that they exhibited significant antibacterial, antifungal and anticancer properties.

    Keywords: anticancer, antimicrobial, Au NPs, Broccoli, Pharmacological agent

    Received: 19 Sep 2024; Accepted: 05 Dec 2024.

    Copyright: © 2024 Baran. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ayşe Baran, Mardin Artuklu University, Mardin, Türkiye

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.