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REVIEW article

Front. Pharmacol.
Sec. Neuropharmacology
Volume 15 - 2024 | doi: 10.3389/fphar.2024.1352927
This article is part of the Research Topic Novel Therapeutic Target and Drug Discovery for Neurological Diseases, Volume II View all 32 articles

Apelin/APJ System: A Novel Promising Target for Anti-oxidative Stress in Stroke

Provisionally accepted
Weilin Xu Weilin Xu 1Jun Yan Jun Yan 2Liansheng Gao Liansheng Gao 3Haijian Wu Haijian Wu 3Jingwei Zheng Jingwei Zheng 3Jianmin Zhang Jianmin Zhang 3Anwen Shao Anwen Shao 3*Jun Yu Jun Yu 3*
  • 1 Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
  • 2 Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Region, China
  • 3 Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    The apelin/APJ system has garnered increasing attention in recent years.In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways.Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke.

    Keywords: Apelin, APJ, Stroke, Oxidative Stress, Neuroprotection

    Received: 09 Dec 2023; Accepted: 10 Dec 2024.

    Copyright: © 2024 Xu, Yan, Gao, Wu, Zheng, Zhang, Shao and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Anwen Shao, Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang Province, China
    Jun Yu, Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.