This article is a correction to:
In Vitro and In Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product From Cucumber
Dinglan Wu1†
Zhu Wang2†
Muqi Lin3†
Yi Shang4Fei Wang5JiaYi Zhou1
Fei Wang1
Xiantong Zhang1
Xiaomin Luo1*
Weiren Huang6*- 1Shenzhen Key Laboratory of Viral Oncology, The Clinical Innovation & Research Centre, Shenzhen Hospital, Southern Medical University, Shenzhen, China
- 2Department of Urology, People’s Hospital of Longhua Shenzhen, Southern Medical University, Shenzhen, China
- 3School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China
- 4Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Science, Shenzhen, China
- 5Department of Urology, The Hospital of Hainan Province, Haikou, China
- 6Department of Urology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, China
A Corrigendum on
In Vitro and In Vivo antitumor activity of cucurbitacin C, a novel natural product from cucumber
by Wu D, Wang Z, Lin M, Shang Y, Wang F, Zhou J, Wang F, Zhang X, Luo X and Huang W (2019). Front. Pharmacol. 10:1287. doi: 10.3389/fphar.2019.01287
In the published article, there was an error in Figures 4, 8 as published. The incorrect images were erroneously inserted.
FIGURE 4
FIGURE 4. CuC induces cell apoptosis. (A) Apoptosis assay of cancer cells with CuC treatment by annexin V-FITC and PI staining. CuC induced significant early apoptosis at 100 mM and 1 µM treatment in T24, HepG2 and PC-3 cells (**, p < 0.01). (B) Western blot (WB) analysis of indicated apoptotic markers after 48 h dosage of serial CuC in T24 and PC-3 cells.
FIGURE 8
FIGURE 8. Molecular working model of CuC in cancer cells. (A) Western blot (WB) analysis of p-Akt and Akt in PC-3, T24, and HepG2 cells with or without CuC. p-Akt (Ser473) was significantly decreased in the presence of 100 nM CuC. Cells were treated for 24 h (B) p-Akt (Ser473) and Akt expression in PC-3 and T24 cells under CuC (100 nM) treatment at different time points (0, 1, 3, 10, and 24 h). (C) Schematic diagram illustrated the bio-relevant context of antitumor activities of CuC, and the proposed cell growth arrest, apoptosis, and cell migration inhibition are illustrated.
Specifically, in Figure 4B, the blot of Caspase 3 of PC-3 cell was inadvertently displayed as the cleaved caspase-3. In Figure 8A, the blot of β-actin image was mistakenly showed, due to the carelessness of the picture combination and image processing. Additionally, there is an error in the caption of Figure 8A. The published legend states: “Western blot (WB) analysis of p-Akt and Akt in PC-3, T24, and LNCaP cells with or without CuC”. The legend of Figure 8A is corrected as: “Western blot (WB) analysis of p-Akt and Akt in PC-3, T24, and HepG2 cells with or without CuC.” Finally, in the caption of Figure 4A, “T-24” is corrected as “T24.”
The corrected Figures 4, 8 and their captions appear below.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: cucurbitacin C, natural product, anti-cancer, growth arrest, apoptosis, Akt pathway
Citation: Wu D, Wang Z, Lin M, Shang Y, Wang F, Zhou J, Wang F, Zhang X, Luo X and Huang W (2024) Corrigendum: In vitro and in vivo antitumor activity of cucurbitacin C, a novel natural product from cucumber. Front. Pharmacol. 15:1334971. doi: 10.3389/fphar.2024.1334971
Received: 08 November 2023; Accepted: 01 February 2024;
Published: 04 March 2024.
Edited and reviewed by:
Christian Celia, University of Studies G. d’Annunzio Chieti and Pescara, ItalyCopyright © 2024 Wu, Wang, Lin, Shang, Wang, Zhou, Wang, Zhang, Luo and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xiaomin Luo, TWlsbG9yZUAxNjMuY29t; Weiren Huang, cG9ueTg5ODBAMTYzLmNvbQ==
†These authors have contributed equally to this work