Rajeev K. Singla
Adriana Gibara Guimarães
Gokhan Zengin- 1Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China
- 2iGlobal Research and Publishing Foundation, New Delhi, India
- 3Federal University of Sergipe, São Cristóvão, Brazil
- 4Selçuk University, Konya, Türkiye
Editorial on the Research Topic
Application of plant secondary metabolites to pain neuromodulation, volume III
Pain is a distressing condition that is often associated with various ailments, including metabolic disorders, viz. cancer and diabetes, neurological diseases like Parkinson’s disease, and chronic infectious diseases (Li et al., 2019; Yang, 2019; Singla et al., 2021a; Singla et al., 2021b; Singla et al., 2022b). Electrical interface-based neuromodulation has shown promise in the treatment chronic pain, significantly where high attrition rates, costs, or regulatory restrictions limit pharmacological agents. To ensure the safe and appropriate use of neurostimulation techniques, the practice guidelines developed by organizations such as the International Neuromodulation Society and the Indian Society for Study of Pain (Deer et al., 2014a; Deer et al., 2014b; James et al., 2018; Thota et al., 2020; Singla et al., 2022b).
In addition to traditional pharmacological and neurostimulator approaches, natural products have emerged as a potential avenue for pain relief (Scotti et al., 2016; Dangar and Patel, 2021; Singla et al., 2021b; Swarnkar et al., 2021; Garg et al., 2022; Kumar et al., 2022; Rauf et al., 2022; Singla et al., 2022a; Singla et al., 2023). Nature has provided various molecules, such as capsaicin, resiniferatoxin, morphine, lipoxin A4, and cannabidiol, which have significantly alleviated pain (Jin et al., 2020; Singla et al., 2020; Singla et al., 2021b). Natural products, in the form of plants, animals, and microbes, has always served as a goldmine and sustainable resource for the production of various compounds that can effectively alleviate hallmark traits of various diseases and disorders (Ramesha et al., 2011; Singla, 2014; Singla and Dubey, 2019; Singla et al., 2021c). Nanotechnological approaches can further enhance the therapeutic properties of pain-related medications by increasing their bioavailability, ADME properties, and site-specific actions (Yetisgin et al., 2020; Ansari and Goomer, 2022; Patil et al., 2022). Recent research has explored the clinical translational potential of gold nanoparticles as an effective neuro-medicine (Mishra et al., 2022). By scientifically exploring the rational use of novel formulation strategies in natural product-based studies, such research may lead to the development of alternative or complementary treatment methods for pain management (Jayasawal et al., 2022; Patel et al., 2022). Thus, this Research Topic aims to collect articles investigating plant metabolites’ potential for pain neuromodulation to provide additional insights in this direction.
Cheng Xu and the team published their clinical trial-based article entitled “The median effective analgesic concentration of ropivacaine in ultrasound-guided interscalene brachial plexus block after arthroscopic rotator cuff repair.” Cheng Xu and the team performed this study on 40 arthroscopic rotator cuff repair (ARCR) patients. They evaluated the mean effective analgesic concentration (MEAC) when treating ARCR patients with 10 mL of ropivacaine. They also assessed sufentanil consumption, the onset time of sensory block and motor block, and some other parameters.
Liqiong Yu and the team summarized the studies on traditional Tibetan medicine and published a review article entitled “Traditional Tibetan medicine: therapeutic potential in rheumatoid arthritis.” In the manuscript, they analysed the common pathways regulating the aberrant pathophysiology in rheumatoid arthritis. They have also made a comparative analysis between the 27 species that were documented as traditional Tibetan medicines and had the potential to manage rheumatoid arthritis cases. The data gathered from various Tibetan medicine monographs and online Chinese and international databases.
Yuan Kang and the team published their research article entitled “Anti-oxidative and anti-inflammatory activities of the ethanol extract of edible flower from Chimonanthus praecox.” Chimonanthi Praecocis Flos is commonly known as the wintersweet flower, and it is an edible flower. The ethanolic extract obtained from these flower buds was subjected to HPLC for component analysis. To validate the anti-oxidative and anti-inflammatory activities, they have performed varied in vitro and in vivo studies, especially that related to the measurement of intracellular reactive oxygen species (ROS), intracellular NADPH oxidase, mtROS, supernatant pro-inflammatory mediators, iNOS, NLRP3 inflammasome activation, luciferase reporter gene, and mouse endotoxemia model.
Reshmi Akter and the team published their research article entitled “Pomegranate juice fermented by tannin acyl hydrolase and Lactobacillus vespulae DCY75 enhance estrogen receptor expression and anti-inflammatory effect.” With the aid of tannin acyl hydrolase and Lactobacillus vespulae, they transformed hydrolyzable tannins present in pomegranate juice into ellagic acid. Fermented pomegranate juice was thus enriched in ellagic acid. They conducted various in vitro experiments to validate the upregulation of estrogen receptor expression as well as anti-inflammatory potential.
Keun-Tae Park and the team published their research article entitled “The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain.” Paclitaxel, a widely known anticancer drug, is also well known for its inducing effect as peripheral neuropathy. They studied the alleviating effects of cucurbitacins B and D on paclitaxel-induced neuropathic pain in mice. But cucurbitacins B expressed higher cytotoxicity for the non-cancerous cell line, which resulted in removing this molecule from further experiments. Without affecting the anticancer potential of paclitaxel, cucurbitacin D expressed potential in reducing neuropathic pain, and authors have validated it with a series of experiments and explored the mechanism of action of cucurbitacin D in peripheral neuropathy.
This Research Topic thus covered one clinical trial, one review, and three original research articles. This Research Topic offers a comprehensive overview of the potential of natural products in managing various forms of neuropathic pain and neuroinflammation. Further translational studies are necessary to ensure the clinical applicability of these natural products. Such studies may shed light on the safety, efficacy, and optimal dosage of these natural products, as well as possible drug-drug interactions. This will help advance the development of alternative or complementary therapies to manage pain.
Author contributions
RS, AG, and GZ have collectively conceived and written the text. All authors contributed to the article and approved the submitted version.
Acknowledgments
We are highly thankful to all the authors for contributing their scholarly work to our Research Topic, and we are indeed grateful to all the reviewers who had spared time from their tight schedules and supported us in the processing of these manuscripts. The authors acknowledge the utilization of ChatGPT in language improvement in some of the contents.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Ansari, Z., and Goomer, S. (2022). Natural gums and carbohydrate-based polymers: Potential encapsulants. Indo Glob. J. Pharm. Sci. 12, 01–20. doi:10.35652/igjps.2022.12001
Dangar, D., and Patel, N. (2021). Anti-inflammatory effect of neuracanthus sphaerostachyus dalz. Leaves on experimental colitis in rats. Indo Glob. J. Pharm. Sci. 11 (01), 07–14. doi:10.35652/igjps.2021.111002
Deer, T. R., Mekhail, N., Petersen, E., Krames, E., Staats, P., Pope, J., et al. (2014a). The appropriate use of neurostimulation: Stimulation of the intracranial and extracranial space and head for chronic pain. Neuromodulation appropriateness consensus committee. Neuromodulation Technol. A. T. Neural Interface 17 (6), 551–570; discussion 570. doi:10.1111/ner.12215
Deer, T. R., Mekhail, N., Provenzano, D., Pope, J., Krames, E., Thomson, S., et al. (2014b). The appropriate use of neurostimulation: Avoidance and treatment of complications of neurostimulation therapies for the treatment of chronic pain. Neuromodulation appropriateness consensus committee. Neuromodulation Technol. A. T. Neural Interface 17 (6), 571–597; discussion 597-598. doi:10.1111/ner.12206
Garg, S., Singla, R. K., Rahman, M. M., Sharma, R., and Mittal, V. (2022). Evaluation of ulcer protective activity of morus alba L. Extract-loaded chitosan microspheres in ethanol-induced ulcer in rat model. Evid. Based Complement. Altern. Med. 2022, 4907585. doi:10.1155/2022/4907585
James, N. D., McMahon, S. B., Field-Fote, E. C., and Bradbury, E. J. (2018). Neuromodulation in the restoration of function after spinal cord injury. Lancet Neurology 17 (10), 905–917. doi:10.1016/s1474-4422(18)30287-4
Jayasawal, P., Rao, N. G. R., and Jakhmola, V. (2022). Microsponge as novel drug delivery system: A review. Indo Glob. J. Pharm. Sci. 12, 21–29. doi:10.35652/igjps.2022.12002
Jin, J., Xie, Y., Shi, C., Ma, J., Wang, Y., Qiao, L., et al. (2020). Lipoxin A4 inhibits NLRP3 inflammasome activation in rats with non-compressive disc herniation through the JNK1/beclin-1/PI3KC3 pathway. Front. Neurosci. 14, 799. doi:10.3389/fnins.2020.00799
Kumar, D., Singla, R. K., Sharma, P., Kumar, L., Kaur, N., Dhawan, R. K., et al. (2022). Phytochemistry and polypharmacological potential of colebrookea oppositifolia Sm. Curr. Top. Med. Chem. 23. doi:10.2174/1568026623666221202112414
Li, H., Yang, T., Tang, H., Tang, X., Shen, Y., Benghezal, M., et al. (2019). Helicobacter pylori infection is an infectious disease and the empiric therapy paradigm should be changed. Precis. Clin. Med. 2 (2), 77–80. doi:10.1093/pcmedi/pbz009
Mishra, N. T. P., Yadav, S., Khantwal, M., Khan, W., and Khan, S. (2022). Clinical translation of gold nanoparticles into effective neuromedicines: Bottlenecks and future prospects. Indo Glob. J. Pharm. Sci. 12, 44–52. doi:10.35652/igjps.2022.12005
Patel, N., Chaudhary, S., and Chaudhary, A. (2022). Emulgel –emerging as a smarter value-added product line extension for topical preparation. Indo Glob. J. Pharm. Sci. 12, 92–103. doi:10.35652/igjps.2022.12008
Patil, P. A., Dalvi, S., Dhaygude, V., and Shete, S. D. (2022). Formulation of silver nanoparticle of Cassia angustifoliaby using green synthesis method and screening for in-vitro anti-inflammatory activity. Indo Glob. J. Pharm. Sci. 12, 183–188. doi:10.35652/igjps.2022.12022
Ramesha, B. T., Gertsch, J., Ravikanth, G., Priti, V., Ganeshaiah, K. N., and Uma Shaanker, R. (2011). Biodiversity and chemodiversity: Future perspectives in bioprospecting. Curr. Drug Targets 12 (11), 1515–1530. doi:10.2174/138945011798109473
Rauf, A., Al-Awthan, Y. S., Khan, I. A., Muhammad, N., Ali Shah, S. U., Bahattab, O., et al. (2022). In vivo anti-inflammatory, analgesic, muscle relaxant, and sedative activities of extracts from Syzygium cumini (L.) skeels in mice. Evidence-Based Complementary Altern. Med. 2022, 1–7. doi:10.1155/2022/6307529
Scotti, L., Singla, R. K., Ishiki, H. M., Mendonca, F. J., da Silva, M. S., Barbosa Filho, J. M., et al. (2016). Recent advancement in natural hyaluronidase inhibitors. Curr. Top. Med. Chem. 16 (23), 2525–2531. doi:10.2174/1568026616666160414123857
Singla, R. K., and Dubey, A. K. (2019). Phytochemical profiling, GC-MS analysis and alpha-amylase inhibitory potential of ethanolic extract of cocos nucifera linn. Endocarp. Endocr. Metab. Immune Disord. Drug Targets 19 (4), 419–442. doi:10.2174/1871530319666181128100206
Singla, R. K., Sultana, A., Alam, M. S., and Shen, B. (2020). Regulation of pain genes—capsaicin vs resiniferatoxin: Reassessment of transcriptomic data. Front. Pharmacol. 11, 551786. doi:10.3389/fphar.2020.551786
Singla, R. K., Agarwal, T., He, X., and Shen, B. (2021a). Herbal resources to combat a progressive and degenerative nervous system disorder- Parkinson’s disease. Curr. Drug Targets 22 (6), 609–630. doi:10.2174/1389450121999201013155202
Singla, R. K., Guimarães, A. G., and Zengin, G. (2021b). Editorial: Application of plant secondary metabolites to pain neuromodulation. Front. Pharmacol. 11, 623399. doi:10.3389/fphar.2020.623399
Singla, R. K., He, X., Chopra, H., Tsagkaris, C., Shen, L., Kamal, M. A., et al. (2021c). Natural products for the prevention and control of the COVID-19 pandemic: Sustainable bioresources. Front. Pharmacol. 12, 758159. doi:10.3389/fphar.2021.758159
Singla, R. K., Dhir, V., Madaan, R., Kumar, D., Singh Bola, S., Bansal, M., et al. (2022a). The genus Alternanthera: Phytochemical and ethnopharmacological perspectives. Front. Pharmacol. 13, 769111. doi:10.3389/fphar.2022.769111
Singla, R. K., Guimaraes, A. G., and Zengin, G. (2022b). Editorial: Application of plant secondary metabolites to pain neuromodulation, volume II. Front. Pharmacol. 13, 1013063. doi:10.3389/fphar.2022.1013063
Singla, R. K., De, R., Efferth, T., Mezzetti, B., Sahab Uddin, M., Sanusi, , et al. (2023). The international natural product sciences taskforce (INPST) and the power of twitter networking exemplified through #INPST hashtag analysis. Phytomedicine 108, 154520. doi:10.1016/j.phymed.2022.154520
Singla, R. K. (2014). Mechanistic evidence to support the anti-hepatitis B viral activity of multifunctional scaffold and conformationally restricted magnolol. Natl. Acad. Sci. Lett. 37 (1), 45–50. doi:10.1007/s40009-013-0195-2
Swarnkar, S. K., Khunteta, A., Gupta, M. K., Jain, P., Sharma, S., and Paliwal, S. (2021). Antinociceptive activity shown by Aerva javanica flowering top extract and its mechanistic evaluation. Indo Glob. J. Pharm. Sci. 11 (01), 33–41. doi:10.35652/igjps.2021.111005
Thota, R., Salins, N., Bhatnagar, S., Ramanjulu, R., Ahmed, A., Jain, P., et al. (2020). Indian society for study of pain, cancer pain special interest group guidelines on palliative care aspects in cancer pain management. Indian J. Palliat. Care 26 (2), 210–214. doi:10.4103/0973-1075.285687
Yang, P. (2019). Maximizing quality of life remains an ultimate goal in the era of precision medicine: Exemplified by lung cancer. Precis. Clin. Med. 2 (1), 8–12. doi:10.1093/pcmedi/pbz001
Keywords: neuropathic pain, nociception, anti-inflammatory agents, phytochemicals, polyphenols, pain
Citation: Singla RK, Guimarães AG and Zengin G (2023) Editorial: Application of plant secondary metabolites to pain neuromodulation, volume III. Front. Pharmacol. 14:1166272. doi: 10.3389/fphar.2023.1166272
Received: 15 February 2023; Accepted: 17 February 2023;
Published: 21 February 2023.
Edited and reviewed by:
Nicholas M. Barnes, University of Birmingham, United KingdomCopyright © 2023 Singla, Guimarães and Zengin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Rajeev K. Singla, cmFqZWV2c2luZ2xhMjZAZ21haWwuY29t; Adriana Gibara Guimarães, YWRyaWFuYWdpYmFyYUBob3RtYWlsLmNvbQ==; Gokhan Zengin, Z29raGFuemVuZ2luQHNlbGN1ay5lZHUudHI=