A bibliometric analysis of the 100 most-cited articles on curcumin

Background: Extensive studies related to curcumin were carried out over the preceding several decades. Citation frequencies represent the most prominent contributions in a specific field. This research aimed to identify and analyze the 100 most-cited articles on curcumin and to highlight the most important advances in this field.

Methods: Highly cited articles were identified in the Web of Science core collection database. “curcumin*” was used as the search string to retrieve in the “Title” field. VOSviewer was applied to perform bibliometric analysis of these papers.

Results: Totally 17,645 publications on the topic of curcumin were identified. The top most-cited 100 articles were published between 1973 and 2017. Most of these papers were original (n = 62). The total citation frequency in the top 100 article ranged from 355 to 3364, with a median of 560. The United States and India were the major countries researching curcumin. The University of Texas M.D. Anderson Cancer Center was the institution with the highest contribution rate of these articles. The most frequently nominated authors were Aggarwal B. B., Kunnumakkara A. B., Prasad S., and Priyadarsini K. I. The top 100 articles were published in 68 journals. The top four journals in terms of the number of our included articles were Cancer Research (n = 7), followed by Journal of Biological Chemistry, Biochemical Pharmacology, and Cancer Letters, with 4 articles each. NF-kappa B, cancer, gene expression, apoptosis, inflammation, chemopreventive agent, and nitric oxide synthase are presumed to be the current hot topics. Bioavailability, anticancer, anti-inflammatory, and antioxidant activities were the major research directions of curcumin.

Conclusion: This study analyzed the 100 most-cited articles on curcumin and provided insights into the characteristics and research hotspots of the articles on this topic.

Introduction

Curcumin [(1E, 6E)-1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Figure 1] is a symmetric molecule, also known as diferuloylmethane, with molecular formula C₂₁H₂₀O₆, and molecular weight of 368.38 (Priyadarsini, 2014). It is isolated of turmeric (Jianghuang in Chinese, haldi in Hindi, and ukon in Japanese) (Sharma, et al., 2005; Jiang, et al., 2017). Turmeric is derived from the rhizome of the plant Curcuma longa L., a perennial herb of the ginger family (Zingiberaceae) that grows extensively in tropical climate (Sharma, et al., 2005; Kocaadam and Şanlier, 2017). India is the initial exporter, and it is also cultivated in Bangladesh, China, Indonesia, Jamaica, and Peru (Zanwar, et al., 2013). Turmeric has been used for a variety of purposes for thousands of years. As a popular oriental spice, it is used to flavor and color food preparations, and is one of the major ingredients of curry powder. Furthermore, it is frequently used in Asian cuisine, especially Indian, Thai, and Pakistani cuisine (Gupta, et al., 2013; Prasad, et al., 2014). In Japan, it is popular as a tea in certain areas, especially in Okinawa (Gupta, et al., 2013). Besides, it is used in cosmetics and as a dye for fabrics such as wool, silk, and cotton (Remadevi, et al., 2007). In addition to the above applications, turmeric has been widely used in Asian countries to treat various diseases for at least 2,500 years (Kocaadam and Şanlier, 2017). Moreover, its use is becoming more and more popular worldwide. For example, in western countries, it is used in mustard blends, sauces, and pickles (Gupta, et al., 2013). In the United States, turmeric is a top selling dietary supplement and the demand for turmeric is steadily increasing (Skiba, et al., 2018). Most of the turmeric consumed in the United States is imported from Asia. However, due to concerns about the quality and production methods of raw materials, the United States began to grow it domestically. And it has been successfully grown in Alabama since 2006 (Shannon, et al., 2019; Setzer, et al., 2021).

FIGURE 1

FIGURE 1. Chemical structure of curcumin.

The most active ingredient of turmeric is curcumin, which typically accounts for 2%–5% of its content (Gupta, et al., 2013). However, a recent study demonstrated that the curcumin content of Uttarakhand Himalayan turmeric ranged from 6.7% to 10.6% at altitudes of 1,400–1700 m (Thapliyal, et al., 2022). Curcumin was first discovered two centuries ago, and its pure compound was obtained in 1842 (Prasad, et al., 2014). The exact chemical structure of curcumin was revealed in 1910. Then, the synthesis of curcumin was reported in 1913, and chromatography was used to isolate and quantify components of curcumin in 1953 (Prasad, et al., 2014; Li, et al., 2020). Curcumin is a crystalline compound with a brilliant orange-yellow color, which is responsible for the intense yellow color of turmeric (Tønnesen and Karlsen, 1985; Li, et al., 2020). Moreover, curcumin is a lipophilic polyphenol, almost insoluble in water, but soluble in methanol, ethanol, acetone, and dimethylsulfoxide (Aggarwal, et al., 2003; Goel, et al., 2008). Besides, curcumin has significant pharmacological activities, including anti-inflammatory (Jurenka, 2009), antioxidant (Abrahams, et al., 2019), anticancer (Vallianou, et al., 2015), and anti-microbial effects (Sarkar, et al., 2016). Experimental and clinical investigations have reported that curcumin is used in the prophylaxis and treatment of various diseases, such as Alzheimer’s disease (Goozee, et al., 2016), cardiac diseases (Jiang, et al., 2017), diabetes (Nabavi, et al., 2015), rheumatoid arthritis (Mohammadian Haftcheshmeh, et al., 2021), cancer (Mbese, et al., 2019), and psoriasis (Bilia, et al., 2018). Furthermore, clinical studies in humans have indicated that curcumin is generally safe, even at high doses of up to 12 g per day for 3 months (Goel, et al., 2008). Nevertheless, poor aqueous solubility and low bioavailability of curcumin are a matter of concern for researchers. The reasons for its low bioavailability include low solubility (<8 μg/ml in water), poor permeability and absorption, and fast metabolism (short elimination half-life < 2 h) (Nangia and Kuthuru, 2018). To overcome the above factors, a great deal of studies have focused on the synthesis of curcumin and its derivatives as well as the development of drug delivery systems to improve bioavailability and pharmacological activities (Wanninger, et al., 2015; Li, et al., 2021). Among them, nanotechnology, liposome encapsulation and various other preparation techniques are utilized (Li, et al., 2005; Mohanty, et al., 2012; Nangia and Kuthuru, 2018). Recently, an interesting study demonstrated the development of a novel catalyst for ethanol fuel cells by combining curcumin and gold nanoparticles (Sai, et al., 2022).

Overall, curcumin has been the research subject of a large number of paper over the past decades. Figure 2 shows the trend of curcumin in scientific research. The earliest record of publications on curcumin in the WOS database is 1905. On the whole, there is an upward trend in the number of papers, indicating an increasing interest in curcumin research. However, the rapid growth of articles makes it difficult to identify the developments and truly influential publications in this area. Bibliometric analysis is a powerful tool for basic science and clinical researchers to access a broad range of knowledge or try to focus on a specific theme, especially when faced with a growing number of publications (García-Fernández, et al., 2020). Citation frequency represents the most important contribution in certain field (Arshad, et al., 2020). Citation analysis is a method of bibliometric analysis in which articles or journals are evaluated and ranked according to the basis citation count (Latif, et al., 2018). Identification milestones in a certain field can be accomplished by analyzing the highly cited studies, especially by analyzing the 100 top-cited studies (Zhang, et al., 2019). The main objective of the current study is to identify the 100 most-cited articles on curcumin and highlight the most notable advances made in the field over the past few decades.

FIGURE 2

FIGURE 2. Trends of curcumin in scientific research. Documents deposited in the WOS database from 1900 to 2021, using “curcumin*” as search term in the “Topic” field.

Materials and methods

Search strategy

Relevant literatures were retrieved from the Web of Science (WOS) core collection database on 20 April 2022. The search strategy was “Title = curcumin*”. The time covered in WOS core collection database is between 1900 and 2022. No limitations were imposed on publication language, publication year, or publication type. The retrieved literatures were listed in descending order according to the number of citations.

Literature inclusion

Double-evaluation method was used, with which two independent researchers evaluated each identified literature to ensure the title contained the word “curcumin” or its derivatives and its content was relevant to curcumin. Meanwhile, retracted articles were excluded. In the end, 100 related literatures with the most citations were obtained.

Data extraction and analysis

VOSviewer 1.6.17 and Microsoft Excel 2013 software were used to analyze and visualize the articles on curcumin. The following information was extracted and analyzed for the included papers: article title, language, publication type, publication year, citation frequency, country, institutions, author, journal, and keywords.

Results

Language, publication type, and publication year analysis

From the WOS Core Collection Database, a total of 17,645 articles were retrieved using the search term “curcumin*” in the “Title” field. The top 100 articles with the highest cited frequency were all published in English. As for the publication type, the articles could be divided into the following categories: original article (n = 62), review (n = 34), note (n = 2), editorial material (n = 1), and letter (n = 1). The distribution of the number of publications by year is shown in Figure 3. The top 100 articles with the highest cited frequency were published between 1973 and 2017. From 1973 to 1994, the number of the 100 most cited articles was 0 or 1, and began to be more than 1 since 1995. Furthermore, most articles were published in 2008 (n = 11), followed by 2009 (n = 9), 2005 (n = 8), and 2007 (n = 8).

FIGURE 3

FIGURE 3. Annual number of publications of the 100 most-cited articles on curcumin.

Citation analysis

In the 100 most-cited articles, the total citation frequency of each article ranged from 355 to 3364, and the median number of citations was 560. The average citation frequency was 696.18, thirty-one articles were cited more than 700 times, and fifteen articles were cited more than 1,000 times. The article with the highest citation frequency, “Bioavailability of curcumin: Problems and promises,” published in Molecular Pharmaceutics in 2007 was cited 3,364 times. The trend in the total number of citations by year is shown in Figure 4. The year with the highest total number of citations was 2008 with 9,126 citations, followed by 2007 with 7,743 citations, 2005 with 5,894 citations, and 2009 with 5,520 citations.

FIGURE 4

FIGURE 4. Per year total citations of the 100 most-cited articles on curcumin.

Country and institution analysis

In terms of the geographical distribution, the 100 most-cited articles were attributed to authors from 18 countries, as shown in Figure 5. The United States was the most productive country with 57 articles, followed by India with 23 articles and England with 9 articles. According to VOSviewer analysis, a total of 120 institutions contributed to the 100 most-cited articles on curcumin, and the institutions with publication quantity ≥ 3 are listed in Table 1. Of the seven institutions, three were from the United States, two from India, and 1 each from England and China. The University of Texas M.D. Anderson Cancer Center was the largest contributor in terms of number of publications (n = 27), followed by the University of Leicester (n = 6), Bhabha Atomic Research Center (n = 5), and University of California, Los Angeles (n = 5).

FIGURE 5

FIGURE 5. Geographical distribution of the 100 most-cited articles on curcumin.

TABLE 1

TABLE 1. Institutions contributing to the 100 most-cited articles on curcumin (number of articles ≥ 3).

Author analysis

The number of scientific papers published by the author, to some extent, represents the author’s contribution and activity in this field (Wu, et al., 2021). A total of 381 authors were involved in the 100 most-cited articles on curcumin, and the authors with the number of published articles ≥ 3 are presented in Table 2. The author who published most articles was Aggarwal BB from the University of Texas M. D. Anderson Cancer Center, whose name appeared in 26 of the top 100 articles. The second most published author, Kunnumakkara AB, came from the same institution, reaching a total of eight articles. The third most published authors were Prasad S and Priyadarsini KI from The University of Texas M. D. Anderson Cancer Center and Bhabha Atomic Research Center, respectively, with five articles each. In addition, there were seven authors who published four articles and 15 authors who published three articles. Of the 26 authors with ≥ 3 documents, 20 were from the United States, three from England, two from China, and one from India.

TABLE 2

TABLE 2. Authors of the 100 most-cited articles on curcumin (number of articles ≥ 3).

Journal analysis

In total, the 100 most-cited articles on curcumin were published in 68 journals (Table 3). The journal with the highest number of publications was Cancer Research (n = 7), followed by Journal of Biological Chemistry, Biochemical Pharmacology, and Cancer Letters, with four articles each. The impact factors (IFs) of these journals ranged from 1.102 to 47.728 (median 5.279); among them, Science had the highest value, followed by Molecular Cancer (27.401), and Blood (23.629). Furthermore, 14 of the top 100 studies were published in journals with an IF more than 10, and 40 were published in journals with an IF more than 5.

TABLE 3

TABLE 3. Journals of the 100 most-cited articles on curcumin.

Article analysis

The details of the top 10 most-cited articles are shown in Table 4. These articles were published between 1997 and 2009, and included 6 reviews, 3 original articles, and 1 editorial material. They were all cited more than 1,200 times. Six of them were published in journals with an IF more than 5. Among the top 10 articles, 3 original articles focused on the mechanisms for treating Alzheimer’s disease (Yang, et al., 2005), phase I clinical trial (Cheng, et al., 2001), and stability and degradation products of curcumin (Wang, et al., 1997), respectively. Four reviews focused on its bioavailability (Anand, et al., 2007), anticancer (Aggarwal, et al., 2003) and other biological activities (Maheshwari, et al., 2006), as well as its potential therapeutic effects on pro-inflammatory diseases (Aggarwal and Harikumar, 2009), respectively. In addition, the other 3 papers reviewed its traditional uses, chemical properties, molecular targets, and clinical studies, etc. (Sharma, et al., 2005; Goel, et al., 2008; Hatcher, et al., 2008).

TABLE 4

TABLE 4. Top 10 most-cited articles on curcumin.

Keyword co-occurrence analysis

VOSviewer software was used to analyze the keywords included in the publications by authors and WOS (KeyWords Plus). A total of 606 keywords were extracted after filtering out keywords with general meaning manually. Only the keywords with a minimum of 4 co-occurrences were visualized, and 52 keywords met the threshold. The network visualization diagram shows the co-occurrence relations of keywords (Figure 6). The size of the circle indicates the number of occurrences of keywords (Wu, et al., 2021). Circles representing keywords such as curcumin, NF-kappa B (NF-κB), cancer, in vitro, gene expression, apoptosis, down-regulation, inflammation, chemopreventive agent, and nitric oxide synthase are larger than others, indicating that these keywords occurred more frequently. Furthermore, all these selected keywords can be roughly divided into into five clusters (red, yellow, green blue, and purple nodes). The top 20 keywords that appeared most frequently are listed in Table 5.

FIGURE 6

FIGURE 6. Keyword co-occurrence network visualization of the 100 most-cited articles on curcumin.

TABLE 5

TABLE 5. Top 20 keywords with most frequent occurrence.

Discussion

In this study, the top 100 highly cited articles on curcumin were identified. Using the scientific method of bibliometric and visualized analysis, our study reflected the global trends of the most frequently cited articles in the field of curcumin research. In terms of the publication type, more than 60 percent of the 100 most-cited articles were original articles and one-third were reviews. It is indicated that in the field of research on curcumin, researchers tend to cite original studies rather than review articles or expert opinions. As for publication years, the 100 most cited papers were first published in 1973, 0 or 1 papers were published from 1973 to 1994, more than 1 paper was published since 1995, and the number reached the highest in 2008. Combined with the research trend of curcumin (Figure 2), it is suggested that a large number of studies on curcumin have been carried out since the 1990s, and then abundant high-quality or breakthrough results have been achieved, especially around 2008. According to the number of citations, the most frequently cited articles in the top 100 ones were cited from 355 to 3,364 times. Of the top 100 articles, nearly 60 percent were from the United States, followed by Asian and European countries. Besides, the University of Texas M.D. Anderson Cancer Center, affiliated with the United States, attributed the largest number of publications (n = 27). Furthermore, most and the top three productive authors were from the United States. In conclusion, all this information indicated that the United States made a dominant contribution to the development of curcumin research. According to the results of the author analysis, Aggarwal B. B., Kunnumakkara A. B., Prasad S., and Priyadarsini K. I. published the most papers among the top 100 cited articles, indicating that they made significant contributions in this field. This conclusion can be confirmed by searching their names in the “Author” field of multiple databases such as WOS, PubMed, etc. They did publish a large number of articles on curcumin.

A total of 68 journals were involved in this study. Among them, Science had the highest IF (47.728), followed by Molecular Cancer (27.401), and Blood (23.629), with one article published in each of these three journals (Bharti, et al., 2003; Egan, et al., 2004; Wilken, et al., 2011). All journals were ranked in descending order according to the number of the 100 most-cited articles they published. The most published journal was Cancer Research, with seven articles, indicating that the research of curcumin in oncology was a hot research direction, and this conclusion could be demonstrated by the fourth published journal (Cancer Letters), the second most-cited article (Cheng, et al., 2001), and the third most frequently appearing keyword (cancer). In terms of publication type, the top 10 most-cited articles were divided into six reviews, three original articles, and one editorial material. From the content of these articles, it covered a wide range of topics, including the chemical properties, bioavailability, biological activity (especially anticancer activity), mechanism, effect on AD, cancer and pro-inflammatory diseases, and clinical studies of curcumin. Based on the results of keyword co-occurrence analysis and filtering out general meaning keywords, NF-kappa B (NF-κB), cancer, gene expression, apoptosis, inflammation, chemopreventive agent, and nitric oxide synthase were the most commonly used keywords, so these terms are presumed to be the hot spots in this field. Combined with the analysis results of the top 10 most-cited articles and keyword co-occurrence, topics that appeared frequently in curcumin research were as follows: bioavailability, anticancer, anti-inflammatory, and antioxidant activities. By retrieving “Hot Papers”, defined as the top 0.1% of papers in the corresponding academic field in WOS, there were six results on curcumin research, published from May 2020 to February 2022. It can be seen from the contents of several articles that the above-mentioned topics are still hot spots of curcumin research in recent years (Reda, et al., 2020; Abd El-Hack, et al., 2021; Kabir, et al., 2021; Zhang, et al., 2021).

Our initial limitation was conducting the search in the “Title” field. Therefore, literatures that did not contain curcumin in the title were not retrieved or included in our study. Second, we only searched in the WOS core collection database, and not in other databases such as PubMed and Scopus. Finally, given that citations gradually peak within 3–10 years after publication, the current analysis is unable to assess recently published articles (Xie, et al., 2021).

Conclusion

This bibliometric analysis provides a visualization of the 100 most-cited articles on curcumin. These papers were published between 1973 and 2017, with most published since the year 1995. Meanwhile, the publication types of these articles were mainly original articles. The United States, India, and England contributed the most highly cited papers. The University of Texas M.D. Anderson Cancer Center was the institution with the highest contribution rate of highly cited articles. The most frequently nominated authors were Aggarwal B. B., Kunnumakkara A. B., Prasad S., and Priyadarsini K. I. A total of 68 journals were involved in the 100 top-cited articles. Among them, Cancer Research and Science were the journals with the largest number of publications and the highest IF, respectively. Keyword co-occurrence analysis indicated that NF-kappa B (NF-κB), cancer, gene expression, apoptosis, inflammation, chemopreventive agent, and nitric oxide synthase were the most frequently used keywords, so these terms are presumed to be the current hot topics. Combined with the results of the article analysis, bioavailability, anticancer, anti-inflammatory, and antioxidant activities were the major research directions of curcumin. This report briefly analyzes the historical development and characteristics of the most frequently cited articles on curcumin, hoping to provide certain perspectives for future research on curcumin or its derivatives.

Data availability statement

The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.

Author contributions

Y-XZ performed search, collected data, conducted analysis, and wrote the manuscript. X-YC re-checked data. CP designed, conceived and supervised process.

Funding

This work was supported by Xinglin Scholar Fund of Chengdu University of Traditional Chinese Medicine (YXRC2018006).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

Abd El-Hack, M. E., El-Saadony, M. T., Swelum, A. A., Arif, M., Abo Ghanima, M. M., Shukry, M., et al. (2021). Curcumin, the active substance of turmeric: Its effects on health and ways to improve its bioavailability. J. Sci. Food Agric. 101 (14), 5747–5762. doi:10.1002/jsfa.11372

PubMed Abstract | CrossRef Full Text | Google Scholar

Abrahams, S., Haylett, W. L., Johnson, G., Carr, J. A., and Bardien, S. (2019). Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review. Neuroscience 406, 1–21. doi:10.1016/j.neuroscience.2019.02.020

PubMed Abstract | CrossRef Full Text | Google Scholar

Aggarwal, B. B., and Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol. 41 (1), 40–59. doi:10.1016/j.biocel.2008.06.010

PubMed Abstract | CrossRef Full Text | Google Scholar

Aggarwal, B. B., Kumar, A., and Bharti, A. C. (2003). Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 23 (1A), 363–398. https://www.researchgate.net/publication/10818418.

PubMed Abstract | Google Scholar

Anand, P., Kunnumakkara, A. B., Newman, R. A., and Aggarwal, B. B. (2007). Bioavailability of curcumin: Problems and promises. Mol. Pharm. 4 (6), 807–818. doi:10.1021/mp700113r

PubMed Abstract | CrossRef Full Text | Google Scholar

Arshad, A. I., Ahmad, P., Karobari, M. I., Asif, J. A., Alam, M. K., Mahmood, Z., et al. (2020). Antibiotics: A bibliometric analysis of top 100 classics. Antibiot. (Basel, Switz. 9 (5), 219. doi:10.3390/antibiotics9050219

CrossRef Full Text | Google Scholar

Bharti, A. C., Donato, N., Singh, S., and Aggarwal, B. B. (2003). Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101 (3), 1053–1062. doi:10.1182/blood-2002-05-1320

PubMed Abstract | CrossRef Full Text | Google Scholar

Bilia, A. R., Bergonzi, M. C., Isacchi, B., Antiga, E., and Caproni, M. (2018). Curcumin nanoparticles potentiate therapeutic effectiveness of acitrein in moderate-to-severe psoriasis patients and control serum cholesterol levels. J. Pharm. Pharmacol. 70 (7), 919–928. doi:10.1111/jphp.12910

PubMed Abstract | CrossRef Full Text | Google Scholar

Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., et al. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21 (4B), 2895–2900.

PubMed Abstract | Google Scholar

Egan, M. E., Pearson, M., Weiner, S. A., Rajendran, V., Rubin, D., Glöckner-Pagel, J., et al. (2004). Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Sci. (New York, N.Y.) 304 (5670), 600–602. doi:10.1126/science.1093941

CrossRef Full Text | Google Scholar

García-Fernández, F. J., García-Fernández, A. E., Nava, E., Del Pozo, J., Ikuta, I., Jordan, J., et al. (2020). A bibliometric evaluation of the top 100 cited natalizumab articles. J. Neuroimmunol. 349, 577379. doi:10.1016/j.jneuroim.2020.577379

PubMed Abstract | CrossRef Full Text | Google Scholar

Goel, A., Kunnumakkara, A. B., and Aggarwal, B. B. (2008). Curcumin as "curecumin": From kitchen to clinic. Biochem. Pharmacol. 75 (4), 787–809. doi:10.1016/j.bcp.2007.08.016

PubMed Abstract | CrossRef Full Text | Google Scholar

Goozee, K. G., Shah, T. M., Sohrabi, H. R., Rainey-Smith, S. R., Brown, B., Verdile, G., et al. (2016). Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. Br. J. Nutr. 115 (3), 449–465. doi:10.1017/S0007114515004687

PubMed Abstract | CrossRef Full Text | Google Scholar

Gupta, S. C., Sung, B., Kim, J. H., Prasad, S., Li, S., and Aggarwal, B. B. (2013). Multitargeting by turmeric, the golden spice: From kitchen to clinic. Mol. Nutr. Food Res. 57 (9), 1510–1528. doi:10.1002/mnfr.201100741

PubMed Abstract | CrossRef Full Text | Google Scholar

Hatcher, H., Planalp, R., Cho, J., Torti, F. M., and Torti, S. V. (2008). Curcumin: From ancient medicine to current clinical trials. Cell. Mol. Life Sci. 65 (11), 1631–1652. doi:10.1007/s00018-008-7452-4

PubMed Abstract | CrossRef Full Text | Google Scholar

Jiang, S., Han, J., Li, T., Xin, Z., Ma, Z., Di, W., et al. (2017). Curcumin as a potential protective compound against cardiac diseases. Pharmacol. Res. 119, 373–383. doi:10.1016/j.phrs.2017.03.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Jurenka, J. S. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev. 14 (2), 141–153.

PubMed Abstract | Google Scholar

Kabir, M. T., Rahman, M. H., Akter, R., Behl, T., Kaushik, D., Mittal, V., et al. (2021). Potential role of curcumin and its nanoformulations to treat various types of cancers. Biomolecules 11 (3), 392. doi:10.3390/biom11030392

PubMed Abstract | CrossRef Full Text | Google Scholar

Kocaadam, B., and Şanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 57 (13), 2889–2895. doi:10.1080/10408398.2015.1077195

PubMed Abstract | CrossRef Full Text | Google Scholar

Latif, A., Kapoor, V., Sipra, Q., Malik, S. U., Bilal, J., Bin Riaz, I., et al. (2018). Disease milestones through bibliometric analysis of the top 100 cited articles in multiple myeloma. Cureus 10 (4), e2438. doi:10.7759/cureus.2438

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, H., Sureda, A., Devkota, H. P., Pittalà, V., Barreca, D., Silva, A. S., et al. (2020). Curcumin, the golden spice in treating cardiovascular diseases. Biotechnol. Adv. 38, 107343. doi:10.1016/j.biotechadv.2019.01.010

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, L., Braiteh, F. S., and Kurzrock, R. (2005). Liposome-encapsulated curcumin: In vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 104 (6), 1322–1331. doi:10.1002/cncr.21300

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, Y., Qaria, M. A., Sethupathy, S., Sun, J., and Zhu, D. (2021). Curcumin production and bioavailability: A comprehensive review of curcumin extraction, synthesis, biotransformation and delivery systems. Industrial Crops Prod. 172 (2021), 114050. doi:10.1016/j.indcrop.2021.114050

CrossRef Full Text | Google Scholar

Maheshwari, R. K., Singh, A. K., Gaddipati, J., and Srimal, R. C. (2006). Multiple biological activities of curcumin: A short review. Life Sci. 78 (18), 2081–2087. doi:10.1016/j.lfs.2005.12.007

PubMed Abstract | CrossRef Full Text | Google Scholar

Mbese, Z., Khwaza, V., and Aderibigbe, B. A. (2019). Curcumin and its derivatives as potential therapeutic agents in prostate, colon and breast cancers. Mol. (Basel, Switz. 24 (23), 4386. doi:10.3390/molecules24234386

CrossRef Full Text | Google Scholar

Mohammadian Haftcheshmeh, S., Khosrojerdi, A., Aliabadi, A., Lotfi, S., Mohammadi, A., and Momtazi-Borojeni, A. A. (2021). Immunomodulatory effects of curcumin in rheumatoid arthritis: Evidence from molecular mechanisms to clinical Outcomes. Rev. Physiol. Biochem. Pharmacol. 179, 1–29. doi:10.1007/112202054

PubMed Abstract | CrossRef Full Text | Google Scholar

Mohanty, C., Das, M., and Sahoo, S. K. (2012). Emerging role of nanocarriers to increase the solubility and bioavailability of curcumin. Expert Opin. Drug Deliv. 9 (11), 1347–1364. doi:10.1517/17425247.2012.724676

PubMed Abstract | CrossRef Full Text | Google Scholar

Nabavi, S. F., Thiagarajan, R., Rastrelli, L., Daglia, M., Sobarzo-Sánchez, E., Alinezhad, H., et al. (2015). Curcumin: A natural product for diabetes and its complications. Curr. Top. Med. Chem. 15 (23), 2445–2455. doi:10.2174/1568026615666150619142519

PubMed Abstract | CrossRef Full Text | Google Scholar

Nangia, A., and Kuthuru, S. (2018). Curcumin: Pharmaceutical solids as a platform to improve solubility and bioavailability. Crystengcomm 20 (24), 3277–3296. doi:10.1039/C8CE00469B

CrossRef Full Text | Google Scholar

Prasad, S., Gupta, S. C., Tyagi, A. K., and Aggarwal, B. B. (2014). Curcumin, a component of golden spice: From bedside to bench and back. Biotechnol. Adv. 32 (6), 1053–1064. doi:10.1016/j.biotechadv.2014.04.004

PubMed Abstract | CrossRef Full Text | Google Scholar

Priyadarsini, K. I. (2014). The chemistry of curcumin: From extraction to therapeutic agent. Mol. (Basel, Switz. 19 (12), 20091–20112. doi:10.3390/molecules191220091

CrossRef Full Text | Google Scholar

Reda, F. M., El-Saadony, M. T., Elnesr, S. S., Alagawany, M., and Tufarelli, V. (2020). Effect of dietary supplementation of biological curcumin nanoparticles on growth and carcass traits, antioxidant status, immunity and caecal microbiota of Japanese quails. Animals. 10 (5), 754. doi:10.3390/ani10050754

CrossRef Full Text | Google Scholar

Remadevi, R., Surendran, E., and Kimura, T. (2007). Turmeric, the Genus Curcuma. Editors P. N. Ravindran, K. N. Babu, and K. Sivaraman (Boca Raton, New York: CRC Press, Taylor and Francis Group) 243, 236–238.

Google Scholar

Sai, P. N., Lakshman, K. V., Sai, S. R., Kiran Kumar, J. K., and Apparao, M. R. (2022). Green synthesis of a novel porous gold-curcumin nanocomposite for super-efficient alcohol oxidation. Nano Energy 94 (2022), 106966. doi:10.1016/j.nanoen.2022.106966

CrossRef Full Text | Google Scholar

Sarkar, A., De, R., and Mukhopadhyay, A. K. (2016). Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases. World J. Gastroenterol. 22 (9), 2736–2748. doi:10.3748/wjg.v22.i9.2736

PubMed Abstract | CrossRef Full Text | Google Scholar

Setzer, W. N., Duong, L., Poudel, A., and Mentreddy, S. R. (2021). Variation in the chemical composition of five varieties of Curcuma longa rhizome essential oils cultivated in north Alabama. Foods (Basel, Switz. 10 (2), 212. doi:10.3390/foods10020212

CrossRef Full Text | Google Scholar

Shannon, D. A., Santen, E. V., Salmasi, S. Z., Murray, T. J., Foshee, W., Greenfield, J. T., et al. (2019). Shade, establishment method, and varietal effects on rhizome yield and curcumin content in turmeric in Alabama. Crop Sci. 59 (6), 2701–2710. doi:10.2135/cropsci2019.04.0262

CrossRef Full Text | Google Scholar

Sharma, R. A., Gescher, A. J., and Steward, W. P. (2005). Curcumin: The story so far. Eur. J. Cancer 41 (13), 1955–1968. doi:10.1016/j.ejca.2005.05.009

PubMed Abstract | CrossRef Full Text | Google Scholar

Skiba, M. B., Luis, P. B., Alfafara, C., Billheimer, D., Schneider, C., and Funk, J. L. (2018). Curcuminoid content and safety-related markers of quality of turmeric dietary supplements sold in an urban retail marketplace in the United States. Mol. Nutr. food Res. 62 (14), e1800143. doi:10.1002/mnfr.201800143

CrossRef Full Text | Google Scholar

Thapliyal, M., Panwar, S., Rana, D., Pant, M., Semwal, P., Sharma, U., et al. (2022). Biochemical analysis of curcumin content of turmeric (Curcumin longa) from Himalayan region of Uttarakhand and its economic potential. Biochem. Cell. Archives 22 (1), 1509–1514. Available at: https://connectjournals.com/03896.2022.22.1509.

Google Scholar

Tønnesen, H. H., and Karlsen, J. (1985). Studies on curcumin and curcuminoids. Z. Leb. Unters. Forch. 180, 132–134. doi:10.1007/BF01042637

CrossRef Full Text | Google Scholar

Vallianou, N. G., Evangelopoulos, A., Schizas, N., and Kazazis, C. (2015). Potential anticancer properties and mechanisms of action of curcumin. Anticancer Res. 35 (2), 645–651. https://ar.iiarjournals.org/content/35/2/645.long.

PubMed Abstract | Google Scholar

Wang, Y. J., Pan, M. H., Cheng, A. L., Lin, L. I., Ho, Y. S., Hsieh, C. Y., et al. (1997). Stability of curcumin in buffer solutions and characterization of its degradation products. J. Pharm. Biomed. Anal. 15 (12), 1867–1876. doi:10.1016/s0731-7085(96)02024-9

PubMed Abstract | CrossRef Full Text | Google Scholar

Wanninger, S., Lorenz, V., Subhan, A., and Edelmann, F. T. (2015). Metal complexes of curcumin--synthetic strategies, structures and medicinal applications. Chem. Soc. Rev. 44 (15), 4986–5002. doi:10.1039/c5cs00088b

PubMed Abstract | CrossRef Full Text | Google Scholar

Wilken, R., Veena, M. S., Wang, M. B., and Srivatsan, E. S. (2011). Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer 10, 12. doi:10.1186/1476-4598-10-12

PubMed Abstract | CrossRef Full Text | Google Scholar

Wu, H., Zhou, Y., Wang, Y., Tong, L., Wang, F., Song, S., et al. (2021). Current state and future directions of intranasal delivery route for central nervous system disorders: A scientometric and visualization analysis. Front. Pharmacol. 12, 717192. doi:10.3389/fphar.2021.717192

PubMed Abstract | CrossRef Full Text | Google Scholar

Xie, L., Lu, B., Ma, Y., Yin, J., Zhai, X., Chen, C., et al. (2021). The 100 most-cited articles about the role of neurovascular unit in stroke 2001-2020: A bibliometric analysis. CNS Neurosci. Ther. 27 (7), 743–752. doi:10.1111/cns.13636

PubMed Abstract | CrossRef Full Text | Google Scholar

Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., et al. (2005). Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J. Biol. Chem. 280 (7), 5892–5901. doi:10.1074/jbc.M404751200

PubMed Abstract | CrossRef Full Text | Google Scholar

Zanwar, A. A., Badole, S. L., and Menaa, F. (2013). “Curcuma longa: Use for skin disease care,” in Bioactive dietary factors and plant extracts in dermatology. Nutrition and health. Editors R. Watson, and S. Zibadi (Totowa, NJ. New York: Humana Press), 391.

CrossRef Full Text | Google Scholar

Zhang, M., Zhang, X., Tian, T., Zhang, Q., Wen, Y., Zhu, J., et al. (2021). Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis. Bioact. Mat. 8, 368–380. doi:10.1016/j.bioactmat.2021.06.003

CrossRef Full Text | Google Scholar

Zhang, Y., Quan, L., Xiao, B., and Du, L. (2019). The 100 top-cited studies on vaccine: A bibliometric analysis. Hum. Vaccin. Immunother. 15 (12), 3024–3031. doi:10.1080/21645515.2019.1614398

PubMed Abstract | CrossRef Full Text | Google Scholar