Attila Gáspár
Barbara Hutka
Aliz Judit ErnyeyBrigitta Tekla TajtiBence Tamás Varga
Zoltán Sándor Zádori
István Gyertyán*- Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
A Corrigendum on
Intracerebroventricularly injected streptozotocin exerts subtle effects on the cognitive performance of long-evans rats
by Gáspár A, Hutka B, Ernyey AJ, Tajti BT, Varga BT, Zádori ZS and Gyertyán I (2021) Front. Pharmacol. 12:662173. doi: 10.3389/fphar.2021.662173
In the published article, there was an error in Figure 8 as published. The results of a mistaken measurement were shown in Figures 8A, B. Consequently, the numerical values of the t-test comparing the phospho-tau/total tau ratios in the control and STZ treated groups in EXP1 and EXP2 are inadequate. The corrected Figure 8 and its corrected caption appear below:
FIGURE 8. The effect of icv. STZ or citrate buffer (control) treatment on the tissue protein levels of phospho-Tau (A,B) and β-amyloid (C,D) in EXP1 (A,C) and EXP2 (B,D) measured by Western blot. Means ± SEM values are shown. There was no significant difference between the groups in phospho-tau/tau ratio in EXP1 (unpaired t-test: t (14) = −0.19, ns) (A) whereas a trend for an increase in the STZ group can be seen in EXP2 (unpaired t-test: t (22) = −2.012, p = 0.06) (B) Also, there was no significant difference in β-amyloid level in EXP1 (unpaired t-test: t (13) = −1.13, ns) (C) while significantly elevated β-amyloid level was found in the STZ-treated group in EXP2 (unpaired t-test: t (20) = −2.45, p < 0.05 (D) *<0.05, #<0.10.
Furthermore, the name and catalogue number of the phospho-tau antibody in the Western Blot section was erroneous. As such, a correction has been made to “Methods and materials, Western Blot.” The sentence previously stated:
“Membranes were incubated with primary antibodies against PHF1 (sc515013, 1:1,000, Santa Cruz Biotechnology, Santa Cruz, CA, United States)…”
The corrected sentence appears below:
“Membranes were incubated with primary antibodies against PHF-13 (sc32275, 1:1,000, Santa Cruz Biotechnology, Santa Cruz, CA, United States)…”
The numerical values of the multivariate analysis of variance results were also inadequate. Therefore, a correction has been made to “Results, Multivariate analysis of variance.” The sentence previously stated:
“The difference between the control and STZ groups was significant in EXP2 (Wilks λ = 0.391, F(4,13) = 5.054; p = 0.011) whereas it was not significant in EXP1 (Wilks λ = 0.750, F(4,7) = 0.583; p = 0.685298344).”
The corrected sentence appears below:
“The difference between the control and STZ groups was significant in EXP2 (Wilks λ = 0.397, F(4,13) = 4,931; p = 0.012) whereas it was not significant in EXP1 (Wilks λ = 0.583, F(4,6) = 1.072; p = 0.446).”
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. This is a provisional file, not the final typeset article
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Keywords: Alzheimer disease model, STZ icv., cognitive test battery, learning impairment, β-amyloid, phospho-tau
Citation: Gáspár A, Hutka B, Ernyey AJ, Tajti BT, Varga BT, Zádori ZS and Gyertyán I (2023) Corrigendum: Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats. Front. Pharmacol. 13:1122260. doi: 10.3389/fphar.2022.1122260
Received: 12 December 2022; Accepted: 16 December 2022;
Published: 05 January 2023.
Edited and reviewed by:
Arjan Blokland, Maastricht University, NetherlandsCopyright © 2023 Gáspár, Hutka, Ernyey, Tajti, Varga, Zádori and Gyertyán. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: István Gyertyán, gyertyan.istvan@med.semmelweis-univ.hu