AUTHOR=Wilde Maurice , Pichini Simona , Pacifici Roberta , Tagliabracci Adriano , Busardò Francesco Paolo , Auwärter Volker , Solimini Renata TITLE=Metabolic Pathways and Potencies of New Fentanyl Analogs JOURNAL=Frontiers in Pharmacology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00238 DOI=10.3389/fphar.2019.00238 ISSN=1663-9812 ABSTRACT=
Up to now, little is known about the metabolic pathways of new fentanyl analogs that have recently emerged on the drug markets worldwide with high potential for producing addiction and severe adverse effects including coma and death. For some of the compounds, limited information on the metabolism has been published, however, for others so far no information is available. Considering the well characterized metabolism of the pharmaceutically used opioid fentanyl and the so far available data, the metabolism of the new fentanyl analogs can be anticipated to generally involve reactions like hydrolysis, hydroxylation (and further oxidation steps),