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PERSPECTIVE article

Front. Pediatr.
Sec. Pediatric Endocrinology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1504874
This article is part of the Research Topic Insights in Pediatric Endocrinology: 2024 View all 17 articles

Critical Appraisal Of Diagnostic Laboratory Tests In The Evaluation Of Central Precocious Puberty

Provisionally accepted
Kanthi Bangalore Krishna Kanthi Bangalore Krishna *Luigi R Garibaldi Luigi R Garibaldi
  • Department of Pediatrics, Children’s Hospital of Pittsburgh, Pittsburgh, United States

The final, formatted version of the article will be published soon.

    Pubertal onset is characterized by reactivation of the hypothalamic-pituitary-gonadal axis resulting in pulsatile gonadotropin secretion and subsequent sex steroid production. An accurate measurement of the gonadotropins and sex steroids are essential to ensure timely diagnosis of precocious puberty, so as to determine optimal management. This review summarizes the available laboratory testing for the diagnosis of puberty, discussing the different assays used while reviewing the limitations of such testing.

    Keywords: Puberty, precocious puberty, GnRHa, LH, FSH

    Received: 01 Oct 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Bangalore Krishna and Garibaldi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kanthi Bangalore Krishna, Department of Pediatrics, Children’s Hospital of Pittsburgh, Pittsburgh, United States

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