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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Obstetric and Pediatric Pharmacology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1360470
This article is part of the Research Topic Precision Medicine in Pediatrics - Volume II View all 4 articles

Clinical Management of Children with Tic Disorder: Insights from Therapeutic Visits in China-A Real-World Study

Provisionally accepted
jing wang jing wang 1Changyong Luo Changyong Luo 2zhendong wang zhendong wang 3tiegang liu tiegang liu 4*Chen Bai Chen Bai 4yang wang yang wang 5*yuanshuo tian yuanshuo tian 4*qianqian li qianqian li 4*zhaoxin wang zhaoxin wang 4*liqun wu liqun wu 2*Sumei Wang Sumei Wang 2*xiaohong gu xiaohong gu 4*
  • 1 Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
  • 2 Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, Beijing, China
  • 3 Beijing Gulou Hospital of Traditional Chinese Medicine, Dongcheng Qu, Beijing, China
  • 4 Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
  • 5 Beijing Jishuitan Hospital, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Objective: This retrospective study aims to investigate the treatment of tic disorder (TD) in Dongfang Hospital affiliated with Beijing University of Chinese Medicine, explore its underlying mechanism, and provide valuable insights for future research and clinical management of TD.Methods: Electronic medical records of children with TD from 2015 to 2021 were extracted from the information system of Dongfang Hospital affiliated with Beijing University of Chinese Medicine. The clinical characteristics of TD, utilization patterns of Chinese herbal medicine and synthetic drugs in prescriptions, as well as their pharmacological effects, were statistically described and categorized.Additionally, association rules and network pharmacology were employed to identify core prescriptions (CP) and elucidate their microscopic molecular mechanisms in treating TD.The age range of the children was 6 to 11 years, with a higher proportion of male participants than female ones. The average duration of treatment was 6 weeks.The treatment regimen Z for TD was summarized as: Chinese herbal medicine (Saposhnikoviae Radix (FangFeng), Puerariae Lobatae Radix (GeGen), Uncariae Ramulus cum uncis (GouTeng), Acori Tatarinowii Rhizoma (ShiChangPu), Chuanxiong Rhizoma (ChuanXiong), etc. and vitamins (Lysine Inosite and Vitamin B12 Oral Solution, etc.) as the basic treatment, combinated with Immunomodulator, Antibiotics, Electrolyte Balancing Agents, Antiallergic Agents. CP primarily exerted its effects through modulation of gene expression (transcription), the immune system, and the signal transduction pathways, particularly Interleukin-4 and interleukin-13 pathways being crucial.Among Lysine synthetic drugs used, Inosite and Vitamin B12 Oral Solution were the most frequently prescribed .The drug treatment Regimen Z holds significant importance in the field, which exerted therapeutic effects through a multitude of pathways and intricate 3 interventions. Chinese herbal medicine primarily regulated immune system-related pathways, while synthetic drugs predominantly consisted of vitamins.

    Keywords: tic disorder, Real-world study, therapeutic medication, electronic med ical data, Traditional Chinese Medicine

    Received: 23 Dec 2023; Accepted: 05 Jun 2024.

    Copyright: © 2024 wang, Luo, wang, liu, Bai, wang, tian, li, wang, wu, Wang and gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    tiegang liu, Beijing University of Chinese Medicine, Beijing, 100029, Beijing Municipality, China
    yang wang, Beijing Jishuitan Hospital, Beijing, 100035, Beijing Municipality, China
    yuanshuo tian, Beijing University of Chinese Medicine, Beijing, 100029, Beijing Municipality, China
    qianqian li, Beijing University of Chinese Medicine, Beijing, 100029, Beijing Municipality, China
    zhaoxin wang, Beijing University of Chinese Medicine, Beijing, 100029, Beijing Municipality, China
    liqun wu, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, Beijing, China
    Sumei Wang, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, Beijing, China
    xiaohong gu, Beijing University of Chinese Medicine, Beijing, 100029, Beijing Municipality, China

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