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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Oncology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1357093

Long-Term Trends in Cancer Incidence and Mortality Among U.S. Children and Adolescents: A SEER Database Analysis from 1975-2018

Provisionally accepted
Xiaowei Tang Xiaowei Tang 1Jiao Jiang Jiao Jiang 1Shu Huang Shu Huang 2Xiao-Min Shi Xiao-Min Shi 1Huan Xu Huan Xu 1Jia Xu Jia Xu 1Jie-Yu Peng Jie-Yu Peng 1Wei Zhang Wei Zhang 1Lei Shi Lei Shi 1Xiao-Lin Zhong Xiao-Lin Zhong 1Min Kang Min Kang 1Muhan Lü Muhan Lü 1*
  • 1 The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
  • 2 Lianshui County People’s Hospital, Huai’an, China

The final, formatted version of the article will be published soon.

    Background: Childhood and adolescent cancer represent a significant health burden in the United States.Current and precise epidemiological data are crucial to develop effective cancer control plans and ultimately reduce the burden of childhood and adolescent cancer.Methods: We analyzed data obtained from cancer registries in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Age-standardized incidence and death rates, assessed using joinpoint analysis, were quantified as annual percentage changes (APC) and average percentage changes (AAPC). Results: The overall cancer incidence rate in 2008-2018 was 187.9 per 1000000 persons. Cancer incidence rates demonstrated a sustained upward trend, with an APC of 0.8 from 1975 to 2018. Incidence rates during 2008-2018 remained stable among non-Hispanic Black children but increased among other racial and ethnic groups. Leukemias, central nervous system tumors, and lymphomas were the most common cancer groups for patients aged 0-19 years. Cancer death rates decreased among children (AAPC, -1.3 [95% CI, -1.5 to -1.1]) during 2009-2019, while were stable among adolescents during that period.Conclusions: In this study, we analyzed cancer incidence and mortality rates and trends in children aged 0 to 19 years in the United States. Our findings revealed an overall increase in cancer incidence rates among children and adolescents, accompanied by a decline in cancer mortality rates over time. These rates and trends varied by age, sex, and particularly race and ethnicity, highlighting the significance of comprehending and addressing disparities and ultimately reducing the disease burden of childhood and adolescent cancer.

    Keywords: Incidence, pediatric cancer, Cancer death rates, Children and adolescents, trend

    Received: 17 Dec 2023; Accepted: 30 May 2024.

    Copyright: © 2024 Tang, Jiang, Huang, Shi, Xu, Xu, Peng, Zhang, Shi, Zhong, Kang and Lü. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Muhan Lü, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.