Yukun Sun1,†
Haiyan Liu
Peipei Liu
Changfu Hao
Yongjuan Xin- 1Department of Child and Adolescent Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan, China
- 2Department of Emergency Response,Tongren Center for Disease Control and Prevention, Tongren, Guizhou, China
- 3Clinical Systems Biology Laboratories, Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Accumulating evidence indicates that there is a trend of early puberty onset in humans. The early timing of puberty has raised concerns due to its association with significant negative health outcomes. However, overall impact and potential risk of early puberty remain uncertain. In this study, we conducted a comprehensive review of existing epidemiological studies to gain insights into the long-term adverse health effects associated with early puberty. Our objective was to provide a consolidated summary of these outcomes at a population level by considering studies that encompass various indicators of puberty. In all, early puberty has been identified as a potential risk factor for various metabolic diseases, such as obesity, diabetes, cardiovascular diseases (CVD). Children who experience early puberty are more likely to have a higher body mass index (BMI) during adulthood, increasing their risk of obesity. Early puberty also has been found to be an independent risk factor for diabetes mellitus, including gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM), as earlier onset of menarche in girls and voice breaking in boys is associated with a higher prevalence of T2DM. Furthermore, evidence suggests that early puberty may contribute to an elevated risk of CVD, including conditions like coronary heart disease (CHD), stroke, angina, and hypertension. In addition, adolescents who experience early puberty, particularly girls, are more likely to suffer from mental problems, such as behavioral dysfunction and depression. Notably, early puberty has a more significant impact on girls than boys. Further research should consider the underlying mechanisms and potential preventive measures.
The trend of puberty onset
Puberty is a crucial phase in human development, marking the transition from childhood to adulthood and encompassing significant physical, psychological, and social changes. It also signifies the attainment of reproductive capacity, which is essential for the continuity of any species. Typically, puberty begins between the ages of 8–13 years in girls and 9–14 years in boys, lasting for several years (1). However, emerging evidence suggests a trend towards earlier puberty onset in humans (2). Over the past century, many countries have witnessed a decline in the age at which girls experience breast development, pubarche, and menarche. A meta-analysis revealed that the global trend in the age at breast development (thelarche) decreased by nearly three months per decade from 1977 to 2013 (3). In White American girls, the average age of breast development decreased from 10.8 years to 10.3 years from 1948 to 1988–1994, with similar trends observed in Black and Mexican American girls. However, studies from Denmark and British cohorts did not exhibit a consistent downward trend, instead showing fluctuating patterns with an overall decline in girls (4, 5). Studies from Turkish cohort shown that the median age at pubarche development decreased by 0.7 years between 1973 and 2009 in girls (6). The age at menarche in the United States (US) initially declined (7), then stabilized between the 1900s and 1950s, and subsequently showed another decline from the 1990s onwards (8). In contrast, countries like Korea, South Africa, Mexico, and Romania had experienced a continuous decrease in the age at menarche (9–13). Although these observations highlight the variations in the timing of puberty across different populations, they all shown the phenomena of the trend of early puberty.
Research on puberty onset and development in girls has indeed received more attention compared to boys, with a particular focus on the timing of menarche. Although there is fewer epidemiological evidence, studies have also indicated a trend of early puberty in boys. For instance, research has shown that the age at Tanner stage G2 of genital development in White American boys decreased from 11.5 years to 10.1 years from 1951 to 2001 (14). In Europe, the age decreased from 12 years to 11.5 years from 1965 to 1997, considering the attainment of a testicular size of 4 ml as the marker of puberty onset. A recent population-based study in Sweden reported an earlier age of peak height velocity by 1.5 months per decade, which is an indicator of puberty, from 1947 to 1996 (15). Moreover, large-scale studies have suggested that the age at voice breaking is considerably earlier than previously reported (16). Despite the fewer number of studies available, all the above evidence suggesting a downward trend in the age of puberty onset in boys. It is crucial to conduct further research to better understand the factors contributing to early puberty and potential implications of advancing puberty in both sexes. Understanding these trends can help inform preventive measures and interventions to mitigate any potential negative consequences associated with early puberty.
Pubertal markers
Our study aimed to conduct a comprehensive review of available epidemiological studies to summarize the long-term negative health outcomes of early puberty at a population level. Given the significant impact on children and their families, the primary focus was on metabolic and mental disorders. To achieve this, the study integrated studies that encompassed various puberty markers. The characteristics of relevant markers for pubertal timing are summarized in Table 1. In girls,breast development, also known as “thelarche”, is regarded as the gold standard for predicting the onset of puberty (14). This change is typically observed through self-evaluation and evaluation by a healthcare professional through visual inspection and palpation, although it can be challenging to distinguish in obese girls (26). The timing of menarche has received more attention than the timing of other pubertal milestones. There were relatively fewer studies on indicators such as breast development, pubarche, and other markers compared with menarche due to the difficulty in defining clear boundaries in girls. Menarche becomes the most common marker of puberty and is usually self-reported, but it may be susceptible to reporting bias (3). For boys, Genital development at Tanner stage G2 is considered the standard for predicting male puberty onset (27). The first conscious ejaculation is considered the counterpart of menarche in girls (20). Voice breaking, a distinct event during late puberty, is easily observable and noninvasive (21). Additionally, age of peak height velocity is an accurate and precise marker of puberty timing, requiring frequent annual measurements (24).
Table 1. Characteristics of relevant markers for puberty.
Early puberty and metabolic diseases
Puberty plays an important role in the development of metabolic diseases, particularly due to the rapid increase in insulin resistance during this period. The increase in insulin resistance can raise the risk of developing T2DM. Hormonal changes during puberty can also contribute to excess weight gain, increasing the risk of obesity. Early puberty onset can lead to various physical and psychological issues and increase the likelihood of developing metabolic diseases such as obesity, diabetes and cardiovascular diseases (CVD).
Obesity
Obesity has become a major public health concern, with a significant increase in prevalence and associated healthcare costs. According to the WHO, the European region has witnessed an epidemic rise in overweight and obesity, affecting nearly 60% of adults and one in three school-aged children by 2022 (28). Epidemiologists have predicted that the steady increase in life expectancy may soon come to an end if effective population-level interventions are not implemented to curb the prevalence of obesity (29). The relationship between obesity and early puberty is bidirectional. Not only can childhood obesity trigger early puberty, but early puberty also can lead to adult obesity, characterized by high adipose tissue and high BMI. In this review, our primary focus was on the outcomes of the early puberty.
Children who experience early puberty are more likely to have a higher BMI and a greater risk of obesity later in life, with this association being more pronounced in women than in men. These associations often persist into adulthood (Table 2). A meta-analysis found that girls with early menarche had a higher adult BMI by 0.34 kg/m2 compared to girls with menarche after the age of 12 (49). Similar associations have been observed in various countries. In UK, girls with early menarche and boys with early age at voice breaking were at a higher risk of adult obesity compared to those with an average age of puberty (30). Another prospective study found that earlier age at menarche and age at voice breaking predicted a greater adult BMI by 0.52 kg/m2 and 0.34 kg/m2, respectively (31). Additionally, earlier menarche in mothers can predict higher weight and BMI in their children (50). These relationships have been observed in United States and European girls (32–34). After adjusting for confounding factors, earlier age at menarche was associated with a 31% increase in the odds of obesity (BMI between 30 and 34.9 kg/m2) and 34% increase in the odds of super obesity (BMI greater than 35 kg/m2) (35). In Chinese girls, earlier menarche was associated with an increase in BMI by 0.19 kg/m2 and waist circumference by 0.38 cm (36). These associations remained statistically significant when pubertal height growth spurt and peak height velocity were used as pubertal markers, in Finland and China (37, 38), although waist circumference change was not observed in Finland. It is important to note that there is limited research on the association between age at puberty and obesity in boys, with only a few epidemiological studies supporting these findings.
Table 2. Studies of early puberty and metabolic diseases.
All the above evidence clearly indicates that early puberty is a risk factor for obesity in later life. Studies have shown that the association between pubertal timing and adult obesity remains statistically significant even after adjusting for BMI at an early age (31). The study conducted on 5058 subjects found that earlier pubertal timing was associated with higher adult BMI in both sexes, even after adjusting for factors reflecting fetal and childhood growth, including childhood BMI (37). A prospective cohort study found that the inverse association between age at menarche and BMI and obesity in middle age is not explained by confounding due to early childhood BMI. After Adjusting for childhood BMI, the age-adjusted change in mean adult BMI per additional year of age at menarche was −0.57 (−0.71, −0.43) (51). Additionally, a follow-up study found that boys with early age of peak height velocity tended to have higher waist and hip circumference, even after adjusting for childhood adiposity (52). Further researches are needed to examine this relationship between early puberty and obesity while adjusting for BMI.
Diabetes
Diabetes was the ninth leading cause of death worldwide in 2018 (53). The causes of diabetes are complex with multiple factors, including nutritional factors, sedentary lifestyle, and psychosocial factors. Many studies have investigated the relationship between pubertal timing and diabetes. The evidence consistently suggests that early puberty is an independent risk factor for diabetes mellitus, including GDM and T2DM (Table 2). A systematic review in 2020 found that later age at menarche was associated with a lower risk of T2DM/IGT risk (RR = 0.91 per year), even after adjusting for adult adiposity (54). Data from the UK Biobank study indicated that the prevalence of T2DM was higher in girls with earlier menarche with odds ratio of 1.25 and boys with earlier age at voice breaking with odds ratio of 1.24, even after adjusting for socioeconomic position and adiposity (age 40–69 years) (30). Similar associations have been observed in European, Korean and Mexican girls (13, 32, 39). American girls with earlier menarche showed increased blood glucose levels (0.34 ± 0.11 mg/dl) (33). Metabolic markers for T2DM, such as insulin, HOMA-IR and HOMA-β, also showed a negative relationship with age at menarche (34). Studies in two cohorts suggested that earlier menarche was associated with an increased risk of T2DM (40, 41). When age of peak height velocity was used as a marker of puberty, this association was statistically significant in Swedish men after adjusting for childhood BMI (42). A large prospective cohort study found that early pubertal timing was associated with higher adult BMI in both sexes after adjusting for childhood BMI (40). Two other large prospective cohort studies found that a younger age at menarche was associated with an increased risk of T2DM, after adjustment for potential confounders such as body figure using a 9-level figure drawing (55) at age 10 years and BMI at 18 years (56). Additionally, girls with earlier menarche have a higher risk of developing GDM, which can have adverse effects on pregnancy outcomes (57–59). The underlying mechanisms linking early puberty and diabetes are complex and may involve impaired glucose tolerance (38) and β-cell function (53). Further studies are needed to better understand these associations, and the potential mechanisms, which could have important implications for preventive and therapeutic strategies.
Cardiovascular diseases
Cardiovascular disease (CVD) is a severe condition and the leading cause of death worldwide (60). Common risk factors for CVD include high blood pressure, smoking, overweight or obesity, diabetes, and high cholesterol levels. In recent years, numerous epidemiologic studies have analyzed the relationship between early puberty and CVD. Studies suggested that early puberty may increase the risk of CVD, even after adjusting for age and BMI (Table 2). In UK, women with early menarche had a higher risk of CVD, including CHD [age-adjusted hazard ratio (HR) = 1.16] and stroke (age-adjusted HR = 1.22), compared to normal developmental women (43). Consistently, the Million Women study found a 1.27-fold increased risk of CHD and 1.16-fold increased risk of cerebrovascular disease in women with early menarche (44). Angina was also negatively associated with age at menarche in girls and age at voice breaking in boys (30). The Women's Ischemia Syndrome Evaluation study reported a 4.53-fold higher risk of adverse CVD outcomes in women with early age at menarche (≤10 years) (48). Furthermore, a meta-analysis revealed that increase in age at menarche was associated with a 3% lower relative risk of all-cause mortality (61). When age at menarche and age at voice breaking were used as the pubertal markers, children with earlier onset of menarche or voice breaking were more likely to have hypertension in UK and China (30, 46–63). This association was also identified in a meta-analysis of 17 studies (64). These results remained statistically significant even after adjusting for adult BMI (44, 65). Moreover, a birth cohort study and a mendelian randomization study suggested that early puberty is inversely associated with hypertension independent of childhood BMI (45, 66). Early puberty has also been associated with higher risk of stroke, diastolic blood pressure, triglycerides, and decreased high-density lipoprotein cholesterol (33, 37, 47). When integrating data on cardiovascular disease and early puberty, these health metrics can prove to be immensely valuable for cardiologists, healthcare providers, and public health experts in their assessments and decision-making endeavors.
Early puberty and mental disorders
Adolescence is distinguished by swift physical transformations and psychosexual growth. The convergence of rapid physical maturation alongside gradual psychological development in this phase can potentially give rise to aberrant thoughts and behaviors, culminating in a spectrum of psychiatric issues. Such challenges may stem from hormonal fluctuations, social and emotional maturation, and encounters with stressful circumstances.
Behavioral dysfunction
Behavioral dysfunction encompasses various aspects, including substance misuse, antisocial behavior, delinquency, and dating abuse victimization. There is substantial evidence indicating that early puberty is a risk factor for behavioral dysfunction (Table 3). Substance abuse remains a significant concern for adolescent health in Western countries, and it is more prevalent among individuals who experience early puberty (79). Longitudinal studies conducted in North Carolina found that adolescents with early menarche were more likely to engage in substance misuse, such as cigarettes, alcohol, and marijuana compared to their peers (67, 68). Drug abuse in the early menarche group displayed higher levels of self-reported criminality, substance use problems, social isolation, early sexual behavior, and psychiatric problems. By young adulthood, most of these differences had attenuated, but they were more likely to be depressed in young adulthood compared to their counterparts. Early maturers were also more likely to have had many sexual partners (68). Substance misuse can leads to risky sexual behaviors and adolescent pregnancy, with long-term effects such as reduced educational attainment, potential single parenthood, and economic disadvantage later in life (80). The Add Health study conducted in United States revealed that early age at menarche (<11 years) was associated with a higher incidence [5% of 1 standard deviation (SD)] of antisocial behavior compared to those who reached menarche at the mean age of 12 years, and this association often persisted into early-middle adulthood (69). Similarly, self-reported criminal behavior and school bullying are also prevalent among adolescents with early menarche (68, 70). The 2013 Youth Risk Behavior Survey showed that 20.9% of female students and 10.4% of male students in the US reported experiencing physical violence from a dating partner in the past 12 months (81). Early pubertal development, particularly in girls, is a risk factor for dating abuse victimization, as evidenced by several cohort studies (71, 82). Youths who experience dating abuse are at an increased risk of depression, anxiety, eating disorders, substance use and suicidal behavior (83–85). It is important to be vigilant, particularly for girls who mature earlier than their peers, as they may be targeted by older partners and are more likely to experience dating abuse. However, the underlying mechanisms of these associations are not yet fully understood. The social context may play a crucial role in these relationships. Studies have shown that deviant peer groups, negative school experience, harsh parenting, and neighborhood disorganization contribute to the interactions between pubertal timing, criminal behavior, and social competence (86). In fact, a prospective panel study indicated that girls with precocious puberty had a higher likelihood of associating with deviant peer groups and being exposed to harsher parenting practices (87).
Table 3. Studies of early puberty and mental disorders.
Depression
Depression has a significant impact on human's health and well-being, causing more disability-adjusted life years than any other condition (88). Many convincing studies have shown a negative associated between pubertal timing and the incidence of depression (Table 3). Two prospective studies conducted in North Carolina identified that early age at menarche, Tanner stage IV, and higher testosterone levels were significant predictors of a greater risk of depression (OR = 5.8, 95% CI = 1.9–17.9). These disorders can persist into adulthood (69, 72). In China, individuals with early onset of breast development had a higher risk of depression, but this association was moderated when puberty timing was assessed by genitalia development in boys. Meanwhile, an earlier age at onset of public hair development was unrelated to the incidence of depression in girls and boys (73). Data from 630 female twin and sibling pairs showed that the prevalence of depression symptoms was higher in individuals with genetic predispositions toward earlier menarche (74). However, these findings were less evident in boys, as only a few retrospective studies have suggested an association between depression and early puberty or less mature pubertal status in boys. In all, depression symptoms are more pronounced in girls with early puberty than in boys.
In addition, early puberty may increase the risk of bulimia nervosa, anxiety disorders, distress disorders, fear, excessive psychosomatic symptoms, and self-harm (75–77) (Table 3). Notably, studies using data from the Korean Youth Risk Behavior Web-based Survey reported that girls with early menarche were more likely to have suicidal ideation (78). There are several explanations for this increased risk of psychopathology. First, many brain changes occur during puberty, and brain function is influenced by changes in gonadal hormones (89). For example, the release of dopamine, which is linked to certain symptoms of depression, can be influenced by sex hormones (90). Additionally, changes in neural systems may underlie disruptions in sleep, concentration, appetite, and sensation-seeking, which may increase the risk of mental disorders (75). Alternatively, early appearance of secondary sexual characteristics, which differ from those of peers, may increase levels of psychosocial stress and traumatic experiences from peers and adults, ultimately increasing the risk of mental disorders. Poor lifestyles, such as alcoholism and smoking, contribute to early puberty and can also induce mental health problems later in life (91–93).
Conclusions and outlook
Various factors can trigger early puberty, and its effects, both short-term and long-term, have significant implications for the human body. In our current study, we aim to explore the origins of several adult disorders, making it crucial to investigate the long-term effects of early puberty. While many studies focus on the short-term developmental effects of early puberty, our research delves into its enduring impact, specifically on metabolic and mental disorders. Based on all the above, early pubertal timing is a risk factor for health outcomes. Compared to individuals with expected pubertal timing, adolescents with early puberty are more inclined to develop metabolic diseases. Children with early puberty are more likely to have a higher adult BMI and a greater risk of obesity, Studies have suggested that early pubertal timing has a potential causal effect on the risk of CVD, including CHD, stroke, angina, and hypertension. Additionally, it is important to note that adolescents who experience early puberty are more susceptible to mental problems, such as behavioral dysfunction and depression. With emotional disorders being more prevalent among adolescents and adults, investigating the impact of early puberty on psychological disorders will be a critical concern in the future. Therefore, greater attention from pediatricians and psychologists is needed for adolescents with early puberty, and strategies to prevent early puberty may be necessary. We also acknowledge two limitations in the current research. First, there is limited evidence to determine the relationship between early puberty and health outcomes in men. Second, Puberty encompasses various markers, and the use of diverse indicators in numerous studies presents a challenge in achieving an impartial and thorough review. Establishing a gold standard, similar to the BMI in obesity research, would enhance the specificity of studying its impact on metabolic disorders and other conditions. Our understanding of the adverse effects of earlier appearance of pubertal events is still limited. Most of these remain at the population research stage. Further studies are needed to clarify the long-term negative health outcomes of early puberty in men and to uncover the molecular mechanisms underlying the health outcomes of early puberty. This is important for predicting the risk of diseases and developing timely and effective interventions.
Author contributions
YS: Conceptualization, Data curation, Writing – review & editing. HL: Data curation, Formal Analysis, Funding acquisition, Writing – original draft. CM: Conceptualization, Data curation, Writing – review & editing. PL: Conceptualization, Data curation, Writing – review & editing. CH: Conceptualization, Data curation, Writing – review & editing. YX: Conceptualization, Data curation, Formal Analysis, Writing – original draft, Writing – review & editing.
Funding
The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by research grants from the National Natural Science Foundation of China (82173491, 32171171) and the Natural Science Foundation of Henan Province, China (212300410274).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Abbreviations
US, the United States; UK, the United Kingdom; y, year; BMI, body mass index; T2DM, type 2 diabetes mellitus; GDM, gestational diabetes mellitus; CVD, cardiovascular diseases; CHD, coronary heart disease; HR, hazard ratio; IGF-1, insulin-like growth factor 1; HDL, high-density lipoprotein; SD, standard deviation; CI, confidence interval; OC, oral contraceptive; OR, odds ratio; IGT, imparted glucose tolerance; IFG, impaired fasting glucose; MACE, major adverse cardiovascular events; ADA, adolescent dating abuse; PDS, pubertal development scale; y, year; Ref, reference.
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Keywords: early puberty, obesity, diabetes, cardiovascular diseases, behavioral dysfunction, depression
Citation: Sun Y, Liu H, Mu C, Liu P, Hao C and Xin Y (2024) Early puberty: a review on its role as a risk factor for metabolic and mental disorders. Front. Pediatr. 12:1326864. doi: 10.3389/fped.2024.1326864
Received: 24 October 2023; Accepted: 30 August 2024;
Published: 12 September 2024.
Edited by:
Elena Bozzola, Bambino Gesù Children's Hospital (IRCCS), ItalyReviewed by:
Carol F. Elias, University of Michigan, United StatesPaul B. Kaplowitz, Children's National Hospital, United States
Copyright: © 2024 Sun, Liu, Mu, Liu, Hao and Xin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yongjuan Xin, yjxin@zzu.edu.cn
†These authors have contributed equally to this work