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ORIGINAL RESEARCH article

Front. Pediatr., 09 October 2023
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
This article is part of the Research Topic Pediatric Endoscopy and Sedation - Volume II View all 5 articles

Evaluating the use of a customized digital navigation program to optimize bowel preparation in pediatric colonsocopy

\r\nLauren DanknerLauren Dankner1Jose Antonio Quiros
Jose Antonio Quiros2*Diana VolpertDiana Volpert2Ashish Atreja\r\nAshish Atreja3
  • 1Division of Pediatric Gastroenterology, Valley Hospital, Ridgewood, NJ, United States
  • 2Division of Pediatric Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  • 3Chief Information and Digital Health Officer, UC Davis Medical Center, Sacramento, CA, United States

Introduction: Adequate bowel preparation is essential for optimal colonoscopy diagnosis and/or intervention. However, suboptimal bowel preparation occurs in as many as 1 in 3 pediatric colonoscopies, leading to missed diagnoses, procedural complications, wasted resources, and increased costs. We aimed to evaluate the effect of an automated Pediatric Colonoscopy Digital Navigation Program (PC-DNP) on the quality of colonoscopy preparation among pediatric patients.

Methods: The PC-DNP sent patients timely weight-based bowel preparation instructions, video and text-based educational modules, logistical information, and appointment reminders prior to their scheduled diagnostic and/or therapeutic colonoscopies. Physician reported bowel preparation quality among patients/caregivers who were prescribed the PC-DNP were compared to bowel preparation quality of a historical sample of patients/caregivers who received standard care instructions.

Results: We found that the PC-DNP group had significantly higher bowel preparation quality than the standard care group.

Conclusions: These results demonstrated that automated DNPs may be easily implemented into the pediatric gastroenterologists' practice and may help streamline and improve bowel preparation in pediatric patients.

Introduction

Colonoscopy is an endoscopic procedure commonly performed to diagnose and treat pediatric gastrointestinal (GI) conditions including abdominal pain, diarrhea, and hematochezia. Adequate bowel preparation prior to colonoscopy is essential for optimal diagnosis and/or intervention. However, suboptimal bowel preparation occurs in as many as 1 in 3 pediatric colonoscopies, leading to missed diagnoses, procedural complications, and increased costs (1). Ensuring that patients/caregivers fully understand bowel preparation instructions is a key component of achieving adequate bowel preparation (2). Common barriers to good quality bowel preparation include difficulty understanding lengthy instructions, misplacement of the instructions, confusion regarding mixing of the preparation, and lack of clarity on the expected stool appearance (3). Currently, GI practices try to address these barriers through manual interventions and frequent communication by nurses and practice staff, which is labor intensive and provides suboptimal patient experience and outcomes. Digital health technology has recently emerged as an effective approach to addressing such barriers and helping patients better prepare for colonoscopies.

Digital Navigation Programs (DNPs) have been shown to significantly improve colonoscopy preparation quality in adult patients undergoing colonoscopies by providing automated pre-procedure navigation and instructions directly to patients via text-messages, email and/or through patient portal (46). These automated messages include time-based bowel preparation instructions, dietary modification instructions, educational content, and appointment reminders. They are tailored to users and often include facility-specific information. Despite the success of DNPs in improving colonoscopy preparation quality in adults, to date, few studies have investigated their effects in the pediatric population.

In this study, we evaluated the impact of a Pediatric Colonoscopy DNP (PC-DNP) on the colonoscopy preparation quality of pediatric patients. The PC-DNP sent patients timely weight-based bowel preparation instructions, video and text-based educational modules, logistical information, and appointment reminders in preparation for their scheduled diagnostic and/or therapeutic colonoscopy. This study was intended to compare the bowel preparation quality of those who utilized the PC-DNP to those who received standard care instructions.

Methods

Study design & participants

Included in this study were pediatric patients age 20 years and below who underwent diagnostic and/or therapeutic colonoscopies at The Valley Hospital. The Valley Hospital implemented this initiative as part of Digital Transformation Network led by Rx.Health, NY in partnership with American Gastroenterological Association (AGA). Physician-reported bowel preparation quality of patients/caregivers who were prescribed the PC-DNP (from an EHR connected Digital Health Formulary) (Figure 1) were compared retrospectively to bowel preparation quality of a historical sample of patients/caregivers who received standard care cleanout instructions. The latter were weight- based instructions of the same dosing and instructions given as a print out to the parent or guardian prior to the procedure.

FIGURE 1
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Figure 1. Prescriber view of customizable DNP.

The PC-DNP group included patients who underwent a colonoscopy between February 2020 and May 2021. After scheduling a colonoscopy procedure date and time, patients/caregivers were asked by medical staff if they were interested in receiving the PC-DNP which would send them text-message reminders in preparation for their colonoscopy (Table 1 and Figure 2). In addition to undergoing a colonoscopy at The Valley Hospital and providing written consent for study participation, study inclusion criteria included proficiency of reading and speaking the English language, owning a smartphone, and willingness to receive the PC-DNP. The medical staff then initiated the enrollment in the DNP via the of their stool, and instructions on changing/canceling the appointment. The messages also included a link to the full set of bowel preparation instructions.

TABLE 1
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Table 1. PC-DNP texting schedule and message content for polyethylene glycol 3,350 and bisacodyl bowel preparation (20–30 kgs).

FIGURE 2
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Figure 2. Patient view of PC-DNP instructions.

The standard care group consisted of a historical sample of pediatric patients who underwent diagnostic and/or therapeutic colonoscopy between January 2018 and October 2020 at The Valley Hospital and received standard care instructions, given as written instructions, regarding bowel preparation and a phone call reminder of the upcoming procedure date and time. All comparison patients were selected using a random number generator and they were not contacted for this study. Patients were age and sex matched to the intervention group in order to minimize bias. Incomplete procedures were excluded from analysis.

Data collection & analysis

Procedure indications and procedure outcomes were obtained through electronic health record (EHR) review. Similarly, bowel preparation quality (excellent/good, fair, or poor) as reported by the physician (proceduralist) was also obtained through EHR review. Those without a documented bowel preparation score were scored retrospectively based on images by one of the researchers. These outcomes were assessed using Pearson Chi-Square Tests, with P = .05 used as the threshold for statistical significance. This study was approved by the Institutional Review Board at The Valley Hospital.

Results

Population

One hundred seventeen pediatric patients (mean age = 13 y, range = 2–19) who underwent diagnostic and/or therapeutic colonoscopy at Valley Hospital met inclusion criteria for the study. The PC-DNP group consisted of 56 patients (mean age = 13 y, range = 3–19) and the standard care group consisted of 61 patients (mean age = 13 y, range = 2–18).

Procedure indications and outcomes

There were no significant differences in procedure indications between the PC-DNP and standard care groups. Similarly, there were no significant differences in procedure outcomes, including polyp detection (Table 2).

TABLE 2
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Table 2. Procedure indications, outcomes and bowel preparation quality of standard care and PC-DNP groups.

Bowel preparation outcomes

Of the 56 patients who were prescribed the PC-DNP, the bowel preparation success was recorded as excellent/good for 55 (98.2%) of the patients, and as fair for 1 (1.8%) patient (Table 2). Of the 61 patients who received standard care, the bowel preparation success was recorded as excellent/good for 51 (83.6%) patients, as fair for 9 (14.8%) patients, and as poor for 1 patient (1.6%). There was a significant difference in bowel preparation quality between the PC-DNP and the standard care groups (P < .01) (Table 2 and Figure 3).

FIGURE 3
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Figure 3. Bowel preparation quality comparison.

Discussion

The PC-DNP provided an automated channel for guiding pediatric patients through their colonoscopy preparation. We found that pediatric patients/caregivers who were prescribed the PC-DNP had significantly higher bowel preparation quality than patients who received standard care. These results demonstrate that automated DNPs such as the PC-DNP may be used to improve bowel preparation quality and completion rates for pediatric patients.

The PC-DNP addresses key barriers to adequate bowel preparation including difficulty understanding and/or misplacement of lengthy bowel preparation instructions. By sending patients/caregivers time-based text-messages with multi-media educational materials and specific instructions on bowel preparation, diet, and stool appearance, patients/caregivers were able to build a better understanding of proper bowel preparation, as evidenced by improved bowel preparation quality.

In this study, there were no significant differences in polyp detection between the PC-DNP and standard care groups, despite there being a significant difference in bowel preparation quality. This, however, may be attributed to the overall low incidence of polyp detection in pediatrics.

Multiple studies have demonstrated that improved bowel preparation leads to improved polyp detection and that in adults, DNPs similar to the PC-DNP can increase adenoma detection (6, 7). Additionally, the DNP in other studies has been shown to reduce the no-show rates in adults, reduce the rates of aborted procedures and increase patient satisfaction (4, 8). The PC-DNP are now expanded to support advanced endoscopy procedures as well as surgeries and imaging in many service lines.

Limitations of the study included lack of randomization between the two groups and our small sample size. This study was limited to a retrospective control group given the DNP had already been implemented successfully in our clinic. Additionally, the bowel preparation scoring was not documented by the proceduralist on all colonoscopy reports in both the DNP and control group, and was scored in these cases retrospectively and unblinded by one of the researchers which can introduce bias. The low incidence of polyp detection in pediatric colonoscopy in general limits polyp/adenoma detection rate as an outcome.

Another limitation of the study was the eligibility criteria of having a Smartphone, which may have limited its generalizability to those without digital skills or access to a Smartphone. Since the completion of study, the program has now expanded to include anyone with a cellular or landline. Patients who are not engaged or do not have a Smartphone can now get interactive voice response (IVR) to their phone along with an alert to practice staff to proactively follow up with the patient. Further studies are needed to assess impact of DNP in addressing digital health inequity and measuring overall savings by decreasing personnel costs through automation.

To our knowledge, this is one of few studies investigating the impact of DNPs on bowel preparation quality of pediatric patients (9). Our results provide evidence that DNPs such as the PC-DNP can be used to successfully improve pediatric patient colonoscopy preparation. Future studies are needed to further examine the benefits of DNPs on improving outcomes and satisfaction of pediatric patients across additional diseases and procedures.

Data availability statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Ethics statement

The studies involving humans were approved by Valley Hospital Institutional Review Board. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation was not required from the participants or the participants’ legal guardians/next of kin in accordance with the national legislation and institutional requirements.

Author contributions

LD: Writing original draft. JQ: Writing – original draft. DV: Writing – original draft. AA: Conceptualization, Software, Writing review & editing.

Funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.

Conflict of interest

The Digital Health Formulary is licensed from Icahn School of Medicine at Mount Sinai to Rx.Health, Inc. (New York, NY) and the Digital Navigation Program was built in collaboration with American Gastroenterological Association. AA is on the Board of Directors of Rx.Health, owns stock and has recused himself from data analysis. Nicole Wedel is a Clinical Analyst at Rx.Health.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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Keywords: pediatric endoscopy, endoscopy, digital health, bowel preparation, gastroenterology

Citation: Dankner L, Quiros JA, Volpert D and Atreja A (2023) Evaluating the use of a customized digital navigation program to optimize bowel preparation in pediatric colonsocopy. Front. Pediatr. 11:1271222. doi: 10.3389/fped.2023.1271222

Received: 1 August 2023; Accepted: 6 September 2023;
Published: 9 October 2023.

Edited by:

Andrew S. Day, University of Otago, New Zealand

Reviewed by:

Savas Tsikis, Harvard Medical School, United States
Enrico Felici, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Italy
Michael Wilsey, University of South Florida, United States

© 2023 Dankner, Quiros, Volpert and Atreja. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: J. Antonio Quiros cXVpcmFuQHZhbGxleWhlYWx0aC5jb20=

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.