This article is a correction to:
Brainstem Pain-Modulation Circuitry and Its Plasticity in Neuropathic Pain: Insights From Human Brain Imaging Investigations
Emily P. Mills
Kevin A. Keay
Luke A. Henderson- Brain and Mind Centre, School of Medical Sciences (Neuroscience), University of Sydney, Sydney, NSW, Australia
A Corrigendum on
Brainstem Pain-Modulation Circuitry and Its Plasticity in Neuropathic Pain: Insights From Human Brain Imaging Investigations
by Mills, E. P., Keay, K. A., and Henderson, L. A. (2021). Front. Pain Res. 2:705345. doi: 10.3389/fpain.2021.705345
In the original article, there was a mistake in the legend for Figure 4 as published. This legend is not fully cited, and Dove Medical Press requires acknowledgement as the original publisher. The correct legend appears below.
Figure 4. Spontaneous changes in periaqueductal grey (PAG) - rostral ventromedial medulla (RVM) - spinal trigeminal nucleus (SpV) fMRI signal coupling in chronic neuropathic orofacial pain. Compared to controls, individuals with chronic pain show enhanced positive functional connectivity between the RVM “seed” and the PAG and SpV, in addition to the locus coeruleus (LC) and subnucleus reticularis dorsalis (SRD). Furthermore, in neuropathic pain patients, as the intensity of their clinical pain changes throughout a 12-min fMRI scan, so too do their RVM connectivity strengths with the PAG and SpV. That is, when pain intensity is spontaneously low, RVM connectivity strengths with both the PAG and SpV are low; and when pain intensity is spontaneously high, RVM connectivity strengths are high and positive. *significant between-groups difference determined in a voxel-by-voxel analysis. Figure modified with permission from (1) and Mills et al. Journal of Pain Research 2020:13:2223–2235; Originally published by and used with permission from Dove Medical Press Ltd. (2).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Publisher's Note
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References
1. Mills EP, Di Pietro F, Alshelh Z, Peck CC, Murray GM, Vickers ER, et al. Brainstem pain-control circuitry connectivity in chronic neauropathic pain. J Neurosci. (2018) 38:465–73. doi: 10.1523/JNEUROSCI.1647-17.2017
Keywords: periaqueductal grey, rostral ventromedial medulla, locus coeruleus, subnucleus reticularis dorsalis, chronic neuropathic pain, conditioned pain modulation, functional magnetic resonance imaging, analgesia
Citation: Mills EP, Keay KA and Henderson LA (2021) Corrigendum: Brainstem Pain-Modulation Circuitry and Its Plasticity in Neuropathic Pain: Insights From Human Brain Imaging Investigations. Front. Pain Res. 2:812209. doi: 10.3389/fpain.2021.812209
Received: 09 November 2021; Accepted: 01 December 2021;
Published: 21 December 2021.
Approved by:
Frontiers Editorial Office, Frontiers Media SA, SwitzerlandCopyright © 2021 Mills, Keay and Henderson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Luke A. Henderson, Luke.henderson@sydney.edu.au