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SYSTEMATIC REVIEW article

Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1526268
This article is part of the Research Topic Liver Cancer Awareness Month 2024: Current Progress and Future Prospects on Advances in Primary Liver Cancer Investigation and Treatment View all 7 articles

Drug-eluting beads transarterial chemoembolization vs conventional transarterial chemoembolization in the treatment of hepatocellular carcinoma in adult patients: a systematic review and update metaanalysis of observational studies

Provisionally accepted
Roman Polkin Roman Polkin *Tatiana Chernyshenko Tatiana Chernyshenko Ekaterina Dvoinikova Ekaterina Dvoinikova Valeriy Shepelev Valeriy Shepelev Roman Goncharuk Roman Goncharuk
  • Far Eastern Federal University, Vladivostok, Primorsky Krai, Russia

The final, formatted version of the article will be published soon.

    Study Design. Systematic review and update meta-analysis.Purpose. The present systematic review and meta-analysis were conducted to compare the efficacy and safety of the two approaches for HCC in adult patients (DEB-TACE vs cTACE).Overview of Literature. The TACE procedure is indicated for the treatment of HCC with intermediate (BCLC B) and early (BCLC A). Conflicting data obtained from earlier meta-analyses comparing DEB-TACE with sTACE prompted the updated meta-analysis.Methods. The study included adult patients over the age of 18 with HCC. MEDLINE conducted a literature search using Pubmed and Google Scholar up to May 2024. The following parameters were evaluated: the effectiveness of the tumor response to treatment according to the mRecist criteria (CR, PR, SD, PD), overall survival, progression-free survival, and complication rate. 32 retro-and prospective studies were analyzed.Results. The study included 4,367 patients. The radiological response of the tumor in all four CR, PR, SD, and PD parameters in the DEB-TACE group showed the best response. The overall survival rate during the DEB-TACE procedure was higher by 3.54 months (p <0.00001), and progression-free survival (PFS) by 3.07 months (p <0.0001), respectively. The incidence of complications was comparable in both groups.Conclusions. The results of the meta-analysis revealed clinically significant advantages of DEB-TACE in comparison with cTACE. Being comparable in terms of the frequency of complications, DEB-TACE demonstrated the best result in the radiological response of the tumor to the therapy, in terms of overall survival and progression-free survival.

    Keywords: transarterial chemoembolization, drug-eluting beads, Hepatocellular Carcinoma, Systematic review, Meta-analysis, Drug-eluting beads

    Received: 11 Nov 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Polkin, Chernyshenko, Dvoinikova, Shepelev and Goncharuk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Roman Polkin, Far Eastern Federal University, Vladivostok, 690950, Primorsky Krai, Russia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.