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CASE REPORT article
Front. Oncol.
Sec. Pediatric Oncology
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1443553
This article is part of the Research Topic Pediatric Myeloid Neoplasms: New Insights Into Diagnosis, Prognosis, and Treatment View all 4 articles
Case Report: Gastric Langerhans Cell Histiocytosis with BRAF Deletion Mutation in a Child that was Misdiagnosed as Lymphoma
Provisionally accepted- Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Langerhans cell histiocytosis (LCH) is a myeloid neoplasm associated with the infiltration of most organs but rarely involves the stomach. Stomach tumors in children are very rare and can be easily misdiagnosed. We report the first case of gastric LCH in a 9-year-old boy who was misdiagnosed with gastric lymphoma. The patient presented to our outpatient department with recurrent abdominal pain that had lasted 1 month. Due to the absence of typical clinical features associated with lymphoma in the boy, the initial diagnosis of lymphoma based on the first gastric pathological biopsy was questioned. The second pathological examination revealed that the tumor cells expressed CD1a, S-100, and Langerin with BRAF (c.1457_1471del) deletion mutations. The patient’s condition rapidly improved after chemotherapy with prednisone and vincristine. This case report focuses on the possibility of gastric LCH in school-aged children and the differential diagnosis of gastric tumors in children.
Keywords: langerhans cell histiocytosis, Stomach, BRAF, Child, Lymphoma
Received: 13 Jun 2024; Accepted: 20 Dec 2024.
Copyright: © 2024 Zhi, Xue, Ju and jing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wan Zhi, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Tang Xue, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Gao Ju, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
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