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CASE REPORT article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1420597
This article is part of the Research Topic Current Concepts in Epidemiology, Diagnosis, Associated Co-Morbidities, and Therapeutics of Non-Melanoma Skin Cancers: Beyond Basal Cell and Squamous Cell Carcinomas View all 11 articles

Angiomatoid Fibrous Histiocytoma with EWSR1-CREB1 gene fusion occurs in lungs and ribs with systemic multiple metastases: a case report and review of the literature

Provisionally accepted
Dongmei Feng Dongmei Feng 1Ying Li Ying Li 2Zhengjin Li Zhengjin Li 1Yun Pan Yun Pan 1Yixuan Gao Yixuan Gao 1Jinyan Cha Jinyan Cha 1Chunmei Zhang Chunmei Zhang 1*
  • 1 Department of Pathology, The First Affiliated Hospital of Dali University, Dali, China
  • 2 Department of Pathology, People's Hospital of Xiangyun County, Xiangyun, Yunnan, China

The final, formatted version of the article will be published soon.

    Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor with intermediate malignant potential, and it rarely metastasizes. We encountered a unique AFH case where, the tumor was discovered initially in unusual locations-the left lung and the left 4th rib. Combined histological features with FISH and NGS analysis, the diagnosis of AFH was supported, however, it is difficult to determine which of these two is the primary lesion. Eight months after the initial surgery, multiple systemic metastases were detected, eventually leading to the patient's death 18 months later due to widespread metastasis. Our case signifies the first reported occurrence of systemic metastasis in either bone-originating or pulmonary-originating AFH, and it is the initial instance of mortality resulting from multifocal metastasis originating from an atypical site.

    Keywords: Angiomatoid fibrous histiocytoma, Bone, EWSR1-CREB1, Lung, metastasis

    Received: 20 Apr 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Feng, Li, Li, Pan, Gao, Cha and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunmei Zhang, Department of Pathology, The First Affiliated Hospital of Dali University, Dali, China

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