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CASE REPORT article

Front. Oncol.
Sec. Thoracic Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1417936
This article is part of the Research Topic Autophagy and Lung Cancer Therapy: Targeted Drug Development and New Emerging Technology View all 6 articles

Camrelizumab-Induced Immune-Related Toxic Epidermal Necrolysis in Lung Adenocarcinoma: A Case Report and Literature Review

Provisionally accepted
Man Sun Man Sun Huan Zhou Huan Zhou Chen-guang Liu Chen-guang Liu Dan Zang Dan Zang Jun Chen Jun Chen *
  • Second Affiliated Hospital of Dalian Medical University, Dalian, China

The final, formatted version of the article will be published soon.

    Toxic epidermal necrolysis (TEN) is a rare and serious skin reaction. This study reports a case of a patient with lung adenocarcinoma (LUAD) who developed severe TEN after 8 days of treatment with Camrelizumab monotherapy. The patient's condition was effectively relieved with high-dose corticosteroids and intravenous immunoglobulin therapy. The diagnosis and treatment of immune-related TEN are challenging. This is a rare and severe case of TEN associated with the use of Camrelizumab. Additionally, we provide an in-depth understanding of immune-related TEN, summarizing its characteristics and treatment progress through a literature review, aiming to provide reference for the clinical safe application of immune checkpoint inhibitors (ICIs).

    Keywords: Lung Adenocarcinoma, camrelizumab, Immune-related adverse events, toxic epidermal necrolysis, Drug adverse reactions

    Received: 15 Apr 2024; Accepted: 20 Dec 2024.

    Copyright: © 2024 Sun, Zhou, Liu, Zang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jun Chen, Second Affiliated Hospital of Dalian Medical University, Dalian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.