This article is a correction to:
Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy
Nair Hariprasad Haritha1
Akbar Nawab2†
Vinod Vijayakurup2†
Nikhil Ponnoor Anto3
Vijayasteltar B. Liju1Vijai V. Alex1
Areekkara Nisthul Amrutha4
Sreekumar U. Aiswarya5
Mundanattu Swetha1
Balachandran S. Vinod1Sankar Sundaram6Maria V. Guijarro2Thomas Herlevich2Archana Krishna1Nesteena K. Nestory1
Smitha V. Bava5Chittalakkottu Sadasivan4Maria Zajac-Kaye2
Ruby John Anto1*- 1Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India
- 2Department of Anatomy and Cell Biology, Cancer and Genetics Research Complex, University of Florida, Gainesville, FL, United States
- 3The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
- 4Department of Biotechnology and Microbiology, Kannur University, Kannur, India
- 5Department of Biotechnology, University of Calicut, Malappuram, India
- 6Department of Pathology, Government Medical College, Kottayam, India
A Corrigendum on
Targeting thymidylate synthase enhances the chemosensitivity of triple-negative breast cancer towards 5-FU-based combinatorial therapy
by Haritha NH, Nawab A, Vijayakurup V, Anto NP, Liju VB, Alex VV, Amrutha AN, Aiswarya SU, Swetha M, Vinod BS, Sundaram S, Guijarro MV, Herlevich T, Krishna A, Nestory NK, Bava SV, Sadasivan C, Zajac-Kaye M and Anto RJ (2021) Front. Oncol. 11:656804. doi: 10.3389/fonc.2021.656804
In the published article, there was an error in Figure 5A(i) and Figure 5D(ii) as published. The image of excised tumor of animal treated with curcumin that is present in Figure 2A was wrongly placed as image of excised tumor in the control group in Figure 5A(i). In Figure 5D(ii), an error happened during the cropping and placing of the IHC images. The IHC image depicting the expression status of TS in curcumin-treated tumor samples of MDA-MB-231 TS-ve panel was accidentally duplicated and the same image was placed as IHC image depicting the expression status of p-p65 in curcumin-treated tumor samples of MDA-MB-231 TS-ve panel. We have rectified this mistake in the revised Figure 5 and the duplicated images have been replaced by the correct ones. The corrected Figure 5 and its caption appear below.
Figure 5
Figure 5 The role of TS in regulating the synergism of 5-FU and curcumin. [A (i, ii)] Representative images of animals from each experimental group, bearing tumor produced by orthotopic injection of both sets of transduced cells and tumors excised showed a reduction in tumor size upon completion of treatment. (B, C) Graphs showing a comparison of tumor volume of MDA-MB-231TS and MDA-MB-231TS- xenografts, respectively upon completion of treatment. Significant reduction in tumor volume is observed in animals bearing MDA-MB-231TS xenografts, upon treatment with combination while no significant reduction in tumor volume is observed in animals bearing MDA-MB-231TS- xenografts. Data represent two independent sets of experiments and results are shown as the mean ± S.D. P-values were calculated with one-way ANOVA. ***P-values ≤0.001, **P-values ≤0.01 and *P-values ≤0.05; ns represents non-significance. [D (i, ii)] Immunohistochemical analysis of expression status of TS and p65 sub-unit of NF-κB in different treatment groups of MDA-MB-231TS and MDA-MB-231TS- xenografts, respectively.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: breast cancer, thymidylate synthase, chemoresistance, chemosensitization, curcumin, 5-FU
Citation: Haritha NH, Nawab A, Vijayakurup V, Anto NP, Liju VB, Alex VV, Amrutha AN, Aiswarya SU, Swetha M, Vinod BS, Sundaram S, Guijarro MV, Herlevich T, Krishna A, Nestory NK, Bava SV, Sadasivan C, Zajac-Kaye M and Anto RJ (2023) Corrigendum: Targeting thymidylate synthase enhances the chemosensitivity of triple-negative breast cancer towards 5-FU-based combinatorial therapy. Front. Oncol. 13:1302413. doi: 10.3389/fonc.2023.1302413
Received: 26 September 2023; Accepted: 27 October 2023;
Published: 15 December 2023.
Approved by:
Sophia George, University of Miami, United StatesCopyright © 2023 Haritha, Nawab, Vijayakurup, Anto, Liju, Alex, Amrutha, Aiswarya, Swetha, Vinod, Sundaram, Guijarro, Herlevich, Krishna, Nestory, Bava, Sadasivan, Zajac-Kaye and Anto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ruby John Anto, rjanto@rgcb.res.in
†These authors have contributed equally to this work