Walter Mazzucco1,2,3*
Fabrizio Stracci1,4
Gemma Gatta1,5
Angelo D’Argenzio1,6Ettore Bidoli1,7Simona Carone1,8Susanna Vitarelli1,9Maurizio Castelli1,10Santo Fruscione2
Francesco Vitale2- 1Department of Oncology and Public Health, Executive Board of the Italian Network of Cancer Registries (AIRTUM), Milan, Italy
- 2Clinical Epidemiology Unit and Palermo Province Cancer Registry, University Hospital “P. Giaccone”, Palermo, Italy
- 3College of Medicine, University of Cincinnati, Cincinnati, OH, United States
- 4Umbria Regional Cancer Registry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy
- 5Research Department, IRCCS Foundation National Institute Tumor, Milan, Italy
- 6Regional Epidemiological Observatory - Campania Region, Naples, Italy
- 7Friuli-Venezia-Giulia Regional Cancer Registry, IRCCS Oncological Reference Centre of Aviano (CRO), Aviano, Italy
- 8Apulia Regional Cancer Registry, Local health agency of Taranto, Taranto, Italy
- 9Marche Regional Cancer Registry, University of Camerino, Camerino, Italy
- 10Valle d’Aosta Cancer Registry, Local health agency of Valle d’Aosta, Aosta, Italy
Introduction
Population-based cancer registries (PBCRs) are advanced public health systems providing ongoing surveillance through systematic collection, analysis, interpretation, and dissemination of high-quality data on cancer incident cases registered in a defined population residing in a specific geographical area (1, 2). Basically, PBCRs are well equipped for strengthening cancer surveillance, playing a strategic role in making geographic and temporal variation comparisons to highlight cancer epidemics, while assessing the effectiveness of preventive interventions and oncological care (3). Furthermore, many PBCRs provide cancer risk communication to local communities and authorities by using valuable tools to spread epidemiological data on cancer in intelligible ways to better address preventive intervention and changes in lifestyles (4). To these ends, PBCRs link records and merge data from different administrative, demographic and health sources, following international standards, recommendations, and guidelines (5–7). Standards in cancer surveillance have been defined in Europe and several cancer research domains are continuously alimented by the cancer registries networks in support of public health and clinical research, with specific regard to aetiologic research, mass screening evaluation, quality of care, translational prognostics, and survivorship (3). More recently, progress has been documented regarding the PBCRs’ capability to estimate the effectiveness of immunisation programmes against vaccine preventable viral infections associated to cancer as well as of cancer screening programmes to decrease late-stage incidence and mortality (8–10). Much more fruits can be harvested from “RegisTrees” having strong roots (11), including the ones allowing the deterministic linkage between cancer registries and clinical registries to generate real-world evidence on treatments, particularly on elderly patients as well, a target population that is usually not included in clinical trials (12, 13).
However, the latest revision of the European Union (EU) data protection framework and of the General Data Protection Regulation (GDPR), while suggesting a harmonization of health registries requirements for confidentiality and individual consent to data processing, made it raise concerns from researchers and epidemiologists experiencing some excessive restrictions that may hamper data linkages between cancer registries and other sources (14–16).
As documented by a survey on how GDPR could have impacted the running of the daily activities of the cancer registries in different EU countries, conducted in 2018 by the European network of cancer registries (ENCR), some critical points related to the implementation and interpretation of the GDPR emerged from PBCRs (17, 18).
Of interest, in 2017 the European Commission adopted a strategy to implement an interoperability framework, in order to improve “the ability of organizations to interact towards mutually beneficial goals, involving the sharing of information and knowledge by means of the exchange of data between the respective ICT systems” (19). As the digital interoperability was conceived to maximize the use of huge amounts of data, by contrast an unnecessarily strict interpretation of EU data protection regulation may lead to missed data linkages in cancer registration and other epidemiological activities (20). Therefore, the nature and the use of data from cancer registries in public health and research purposes, and their potentialities in the age of health digital interoperability, are herein discussed (16).
Cancer registries and data protection
Within the EU framework the definition of anonymous data is stringent (an individual cannot be identified or identifiable) and open data sharing is likely to violate the GDPR when data aren’t truly anonymised and, thus, not covered by the regulatory indications (14). For these reasons, a specific informed consent from participants is required to make pseudonymised individual data open and accessible, including an explanation of the risk of backwards identification and a disclosure explaining to data subjects what their rights are and how to exercise them (21). Therefore, making pseudonymised individual data derived from primary sources openly accessible may represent a potential threat to the privacy of those patients whose data were already included in cancer registries and are accessed on a retrospective perspective, so posing substantial obstacles to the sharing of data to validate the research results. Moreover, beyond the research purposes, whereas PBCRs institutionally share confidential data with higher administrative levels of surveillance (i.e. from provincial to regional or from regional to national level) to support case aggregation across different areas, a strict interpretation of the rules on confidentiality may introduce differences within a country. The same criticisms may arise of data sharing from one country to another. One possible solution, that has been positively experienced by PBCRs, is the publication on the institutional websites of a disclosure informing patients of the retrospective use of their data for research purposes, while assuring confidentiality and security of the individual data management.
However, even when data are fully anonymised to be shared for research purposes, some concerns might arise from local data protection officers (DPOs) because of a theoretical data breach, potentially allowing hackers to match or bridge information that could make an individual identifiable. Anyway, as access to a primary source itself may imply the possible identification of a patient, the right balance between the risk of potential data confidentiality breach, which is usually very low in PBCRs, and benefits of improving knowledge to prevent and treat cancer, should be considered.
Cancer registries and digital interoperability: Challenges and perspectives in Italy
The recent progress in digitalisation applied to healthcare data flows has been improving the capability of PBCRs to support cancer surveillance, research, and health services planning, because of a reduction in the lag-time needed to produce cancer incidence data (22). These advancements in cancer registration have at the same time projected the PBCRs towards the new horizons of interoperability and federated networks in healthcare (23). If, on one side, development of advanced cancer surveillance systems based on data-driven models, machine learning and artificial intelligence techniques, may be supported, on the other side, legislation implemented to improve access to personal data could reveal to be a double-edged sword, whereas complexity and implications from misinterpretations may sometimes paradoxically result in data becoming more siloed (23). Thus, today more than ever, the design and the establishment of a cancer registry is a complex process requiring updated evidence-based recommendations as well as substantial resources and careful planning (24).
The new frontiers of integrating epidemiological data with data on health determinants and lifestyles profiling, or with information from environmental monitoring, while interoperating different institutional data flows and data sources based on information communication technology, may improve the knowledge on the effects of exposures on health outcomes across a lifespan in different target populations by using suitable data mining solutions (25). Nevertheless, as volume, accuracy and precision of digital geographic information have increased, and the use of sensors and wearable devices may provide more precise data on individual exposures, more concerns regarding individual privacy and confidentiality might come to the forefront (26). This could be particularly relevant when treating data on rare cancer, or other sensitive topics such as childhood tumours, coming from small communities and, therefore, some useful geospatial cryptography secure solutions have been proposed and successfully implemented (26, 27).
Italy documents a very strong tradition in cancer registration (28). PBCRs are part of the public National Health System and, in 2019, a national network of cancer registries was established, opening to active contribution of the stakeholders (e.g. scientific societies, professionals, associations of cancer patients and citizens, etc.) (29, 30). Anyway, as of today, the implementation process of this network aimed at supporting the Italian national cancer registry, whose regulation is in charge of the Ministry of Health in collaboration with the data protection authority, is still ongoing (31). Since the GDPR implementation, professionals (researchers, epidemiologists, registrars) operating in PBCRs have been experimenting on the field a bureaucratization drift in cancer registration, and among the Italian Network of Cancer Registries (AIRTUM) a debate on how to avert or prevent this phenomenon has arisen (32). Both a bureaucratic attitude (eg. denying of data access to provincial CRs because the transmission procedure in place was conceived for regional CRs only) and a defensive approach (eg. retrospectively requiring the permission of the patient to access the clinical record) from DPOs to data sharing between health institutions may also have a negative impact on completeness or timeliness of data production, thus limiting the role of cancer registries in supporting public health, epidemiology, and outcomes research.
More recently, within the National Recovery and Resilience Plan (NRRP), funded by the EU to support Italy in facing the effects of the COVID-19 pandemic, the institution of a National Health Prevention Hub has been implemented and, within the national complementary plan to NRRP, funded by the Italian government, health and environment protection agencies have been engaged in the establishment of a national health-environment-climate prevention system (31, 33).
In both these frameworks, whereas many efforts are addressed in the development of advanced digital functions and tools to allow a full interoperability of health and environmental data sources for innovative community-based surveillance and prevention of diseases, PBCRs are expected to play a central role. These are all extraordinary opportunities that can’t be missed, and the Italian experience may represent a model to be exported to other EU member states (34).
Discussion
In the last decades in Europe, PBCRs acquired extensive experience in generating valid information on cancer epidemiology, assessing effectiveness of preventive intervention and treatment patterns, and supporting health-service management and planning, being involved in a continuous effort to provide an optimal cancer surveillance through intensive collaboration with professional and institutional stakeholders (3, 11, 35, 36). Anyway, intensity of use and data quality of PBCRs have been varying depending on the role they played in the politico, onco-medical and public health settings within each country (37).
In the recent years, according to the GDPR and the technological advancements, several anonymization protocols and procedures have been developed to avoid reidentification across the cancer registration process, including simply categorizing variables into broader categories to add noise to the data (38). In addition, innovative methods have been validated for probabilistic patient-level linkage of health data registries without a unique identifier or on encrypted identifying data, thus preserving integrity and privacy (39, 40). Also, the sharing of good practices for data linkage within EU member states has been proposed (41). Although information technology has played a positive role in quality improvement and facility of cancer registries, more strict restriction strategies, such as identifying authentication levels, controlling and coding data approaches, tailored de-identification methods, and other technical measures, had to be developed to secure the patients’ privacy (22, 42, 43).
More recently, the COVID-19 pandemic emergency has changed the scenario, whereas the public health interest prevailed over the privacy and confidentiality of individuals (44), highlighting the vital importance of digital transformation applied to epidemiological surveillance and contact tracing in offering data-minimizing solutions while protecting fundamental rights (45).
The new interoperability framework implemented by the European Commission was conceived to facilitate the digital transformation and to fill the digital gap and divide, while putting citizens at the core of the system, through the use of digital tools in a trustworthy manner, also for health purposes including cancer prevention (46). Changing the paradigm of interdependencies and collaborations through the introduction of an interoperability culture among stakeholders within the healthcare ecosystems, including cancer registries and other epidemiological surveillance systems and health data sources, has the potential to accelerate the digital transformation to satisfy the citizens’ health demand and to bring a social change at the same time, but clear policies, guidelines and governance at legal, organizational, semantic and technical levels, have to be established on a European level (46). Additionally, challenges of health interoperability may be even more complex with the free movement of European citizens across member states, because cross-border healthcare requires setting up shared practices with respect to patients’ data exchange across the different EU countries (47).
Lastly, activities of relevant public health interest, such as cancer surveillance and research, where individual data are used to improve patients’ outcomes and to preserve population health, should be addressed to avoid any limitation related to privacy.
For all the above-mentioned reasons, researchers and epidemiologists are expected to propose a permanent alliance with policymakers, data protection authorities, and citizens to move over any heterogeneity of application in the privacy rules that may limit the widespread evolution of cancer surveillance and research. Moreover, the scientific societies and the ENCR are called for a joint effort to provide methodological guidelines and recommendations, based on the added value of digitalisation and on a multi-professional approach, to support research in cancer epidemiology while preserving the privacy rights of individuals. Through the use of the recalled innovative digital approaches and models, new frontiers of cancer surveillance can be reached and any privacy threats, including the related ethical, legal, and social issues, could be overcome in the near future.
Author contributions
All individuals listed as authors have contributed to designing, performing or reporting the study and every specific contribution is indicated as follows. WM, FS, and FV: conception and design of the study. WM and FV: supervision. WM, FS, SF, and FV: manuscript writing and drafting. WM, FS, GG, AD’A, EB, SC, SV, MC, SF, and FV: revision of the manuscript. WM, FS, GG, AD’A, EB, SC, SV, MC, SF, and FV: approval of the final version of the manuscript. All authors contributed to the article and approved the submitted version.
Acknowledgments
Authors thanks Boris La Corte, Grazia Seidita, Giancarlo Mendola from the Privacy Team of the Palermo University Hospital “Paolo Giaccone” for their technical support.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
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Keywords: cancer registries, cancer epidemiology, data protection, digitalization, interoperability
Citation: Mazzucco W, Stracci F, Gatta G, D’Argenzio A, Bidoli E, Carone S, Vitarelli S, Castelli M, Fruscione S and Vitale F (2022) Cancer registries and data protection in the age of health digital interoperability in Europe: The perspective of the Italian Network of Cancer Registries (AIRTUM). Front. Oncol. 12:1052057. doi: 10.3389/fonc.2022.1052057
Received: 23 September 2022; Accepted: 18 November 2022;
Published: 06 December 2022.
Edited by:
Paolo Boffetta, Icahn School of Medicine at Mount Sinai, United StatesReviewed by:
Klaus Peter Kraywinkel, Robert Koch Institute (RKI), GermanyFrancesco Giusti, Belgian Cancer Registry, Belgium
Copyright © 2022 Mazzucco, Stracci, Gatta, D’Argenzio, Bidoli, Carone, Vitarelli, Castelli, Fruscione and Vitale. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Walter Mazzucco, d2FsdGVyLm1henp1Y2NvQHVuaXBhLml0