This article is a correction to:
E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1
Jin Li1†
Wei Zhang1†
Jian Gao1
Min Du1
Huimin Li1
Mengge Li1,2
Hui Cong1
Yuan Fang3
Yiyi Liang1
Dan Zhao1
Gang Xiang4
Xiaojing Ma4
Ming Yao1
Hong Tu1*
Yu Gan1*- 1State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 2Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
- 3Organ Transplantation Center, The First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China
- 4State Key Laboratory of Microbial Metabolism, Sheng Yushou Center of Cell Biology and Immunology, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
A Corrigendum on
E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1
By Li J, Zhang W, Gao J, Du M, Li H, Li M, Cong H, Fang Y, Liang Y, Zhao D, Xiang G, Ma X, Yao M, Tu H and Gan Y (2021). Front. Oncol. 11:634167. doi: 10.3389/fonc.2021.634167
In the original article, there were two mistakes in Figure 2 as published. In Figure 2D, the image for 0h shNC group was same as the image for 0h shUBR5-1 group in the wound healing experiment of PANC-1 cells. In Figure 2E, the cell line names above the bar graph (right panel) were incorrectly given as “CFPAC-1” and “BxPC-3”. They should be “CFPAC-1” and “PANC-1”, consistent with the cell line names given in the left panel. The corrected Figure 2 appears below.
FIGURE 2
Figure 2 UBR5 promotes pancreatic cancer migration and invasion in vitro. (A) Relative mRNA expression and (B) protein levels of UBR5 in various pancreatic cancer cells and normal pancreatic cells measured by quantitative real-time PCR and western blot separately. The histogram shows the densitometric analysis of the bands. (C) The protein levels of UBR5 in CFPAC-1 and PANC-1 cells after infection with shNC or shUBR5. The histogram shows the densitometric analysis of the bands. (D, E) Wound healing and invasion assays in CFPAC-1 and PANC-1 cells infected with shNC or shUBR5. (F) The UBR5 protein levels in MIA PaCa-2 and BxPC-3 transiently overexpressing UBR5. The histogram shows the densitometric analysis of the bands. (G, H) Wound healing and invasion assays in MIA PaCa-2 and BxPC-3 transiently overexpressing UBR5. Data represents mean ± SEM (n = 3 independent biological repeats). **P<0.01; ***P<0.001.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: UBR5, metastasis, CAPZA1, ubiquitination, pancreatic cancer
Citation: Li J, Zhang W, Gao J, Du M, Li H, Li M, Cong H, Fang Y, Liang Y, Zhao D, Xiang G, Ma X, Yao M, Tu H and Gan Y (2021) Corrigendum: E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1. Front. Oncol. 11:693855. doi: 10.3389/fonc.2021.693855
Received: 12 April 2021; Accepted: 22 April 2021;
Published: 11 May 2021.
Edited and reviewed by:
Jing Zhang, Shanghai Jiao Tong University, ChinaCopyright © 2021 Li, Zhang, Gao, Du, Li, Li, Cong, Fang, Liang, Zhao, Xiang, Ma, Yao, Tu and Gan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yu Gan, ganyu@shsci.org; Hong Tu, tuhong@shsci.org
†These authors have contributed equally to this work