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REVIEW article

Front. Mol. Neurosci.
Sec. Neuroplasticity and Development
Volume 17 - 2024 | doi: 10.3389/fnmol.2024.1483901
This article is part of the Research Topic Come as You R(NA): Post-transcriptional Regulation Will Do the Rest View all 11 articles

Post-transcriptional regulation of the transcriptional apparatus in neuronal development

Provisionally accepted
Mohammad Nazim Mohammad Nazim *
  • Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, United States

The final, formatted version of the article will be published soon.

    Post-transcriptional mechanisms, such as alternative splicing and polyadenylation, are recognized as critical regulatory processes that increase transcriptomic and proteomic diversity. The advent of next-generation sequencing and whole-genome analyses has revealed that numerous transcription and epigenetic regulators, including transcription factors and histone-modifying enzymes, undergo alternative splicing, most notably in the nervous system. Given the complexity of regulatory processes in the brain, it is conceivable that many of these splice variants control different aspects of neuronal development. Mutations or dysregulation of splicing and transcription regulatory proteins are frequently linked to various neurodevelopmental disorders, highlighting the importance of understanding the role of neuron-specific alternative splicing in maintaining proper transcriptional regulation in the brain. This review consolidates current insights into the role of alternative splicing in influencing transcriptional and chromatin regulatory programs in neuronal development.

    Keywords: post-transcriptional regulation, Alternative Splicing, RNA-Binding Protein, neuronal development, transcription, Epigenetic regulation, transcription factor, Histone-modifying enzyme

    Received: 20 Aug 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Nazim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mohammad Nazim, Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.