Enping Huang
JiaRen Liu
WenBing Ai3- 1Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China
- 2The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China
- 3Yiling Hospital of Yichang City, Yichang, China
Editorial on the Research Topic
New strategies in neuroprotection and neurorepair
Neurological disorders, including central nerve injury and peripheral nerve injury, represent a significant challenge to global public health, afflict nearly 50 million people worldwide (Spudich and Nath, 2022; Liang et al., 2021). Central nervous system (CNS) diseases, including neurodegenerative disorders like Alzheimer's disease (AD) (Scheltens et al., 2021; Monfared et al., 2022) and Parkinson's disease (PD) (Bloem et al., 2021; Tolosa et al., 2021), stroke, spinal cord injury (SCI) (Quadri et al., 2020), glioma, depression, and traumatic brain injury (TBI) (Thapa et al., 2021). Nowadays a large number of new technologies and methods are used in the treatment of neurological injuries. Drug therapy (Wang et al., 2020, 2023), operative treatment (Galgano et al., 2017), and physical therapy (Li et al., 2024) are the most common ways to deal with nerve injury. However, many mechanisms of drug therapy, operative treatment, and physical therapy are still unclear. Therefore, we need to develop new theories and methods in neuroprotection and neurorepair.
This Research Topic contains four papers, which focus on therapeutic strategies for AD, PD, glaucoma, and others neurological disorders. The accepted papers are introduced as follows: In “Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells”, Davra and Benzeroual found that fenofibrate, naringenin, and diosmetin treatments decrease Aβ production induced by apoE4, these are potential therapeutic drugs for AD patients. The paper “Therapeutic value of homeoprotein signaling pathways”, Nardo and Prochiantz reviewed the role and mechanism of ENGRAILED1, ENGRAILED2 and OTX2 in PD, amyotrophic lateral sclerosis, amblyopia and anxiety-related disorders. In “Molecular pathways in experimental glaucoma models”, Bugara et al. reviewed the animal models Of glaucoma and molecular mechanisms involved in the glaucoma development, including TGF-β signaling, neurotrophins, neuroinflammation, chronic oxidative stress, excitotoxicity, ABCA1, Rho-kinase and purinergic signaling pathway. The paper “Neurotoxic lesions of the anterior claustrum influence cued fear memory in rats”, Gu et al. found that aCLA but not pCLA was involved in fear memory and extinction in rats.
In conclusion, the “New strategies in neuroprotection and neurorepair” Research Topic highlights the most recent and novel therapeutic targets in neuroprotection and neurorepair.
Author contributions
EH: Writing – original draft, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization. JL: Writing – review & editing. WA: Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The editorial work was supported by the funding from the National Natural Science Foundation of China (No. 81801876), Natural Science Foundation of Guangdong Province (Grant No. 2018030310300), and the Basic and Applied Research Program funded by the Basic Research Project of Guangzhou (No. 202201011630).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
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References
Bloem, B., Okun, M., and Klein, C. (2021). Parkinson's disease. Lancet. 397, 2284–2303. doi: 10.1016/S0140-6736(21)00218-X
Galgano, M., Toshkezi, G., Qiu, X., Russell, T., Chin, L., and Zhao, L. (2017). Traumatic brain injury: current treatment strategies and future endeavors. Cell Transplant. 26, 1118–1130. doi: 10.1177/0963689717714102
Li, K., Fu, C., Xie, Z., Zhang, J., Zhang, C., Li, R., et al. (2024). The impact of physical therapy on dysphagia in neurological diseases: a review. Front. Hum. Neurosci. 18:1404398. doi: 10.3389/fnhum.2024.1404398
Liang, Z., Currais, A., Soriano-Castell, D., Schubert, D., and Maher, P. (2021). Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders. Pharmacol Ther. 221:107749. doi: 10.1016/j.pharmthera.2020.107749
Monfared, A., Byrnes, M., White, L., and Zhang, Q. (2022). Alzheimer's disease: epidemiology and clinical progression. Neurol Ther. 11, 553–569. doi: 10.1007/s40120-022-00338-8
Quadri, S., Farooqui, M., Ikram, A., Zafar, A., Khan, M., Suriya, S., et al. (2020). Recent update on basic mechanisms of spinal cord injury. Neurosurg Rev. 43, 425–441. doi: 10.1007/s10143-018-1008-3
Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C., et al. (2021). Alzheimer's disease. Lancet 397, 1577–1590. doi: 10.1016/S0140-6736(20)32205-4
Spudich, S., and Nath, A. (2022). Nervous system consequences of COVID-19. Science. 375, 267–269. doi: 10.1126/science.abm2052
Thapa, K., Khan, H., Singh, T., and Kaur, A. (2021). Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets. J Mol Neurosci. 71, 1725–1742. doi: 10.1007/s12031-021-01841-7
Tolosa, E., Garrido, A., Scholz, S., and Poewe, W. (2021). Challenges in the diagnosis of Parkinson's disease. Lancet Neurol. 20, 385–397. doi: 10.1016/S1474-4422(21)00030-2
Wang, C., Cai, X., Wang, R., Zhai, S., Zhang, Y., Hu, W., et al. (2020). Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice. J Neuroinflammation. 17:309. doi: 10.1186/s12974-020-01976-1
Keywords: neurological disorders, AD, PD, neuroprotection, neurorepair
Citation: Huang E, Liu J and Ai W (2024) Editorial: New strategies in neuroprotection and neurorepair. Front. Neurosci. 18:1461195. doi: 10.3389/fnins.2024.1461195
Received: 08 July 2024; Accepted: 30 August 2024;
Published: 19 September 2024.
Edited and reviewed by: Guo-Yuan Yang, Shanghai Jiao Tong University, China
Copyright © 2024 Huang, Liu and Ai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Enping Huang, ZW5waW5naHVhbmcmI3gwMDA0MDsxNjMuY29t