Avital Schurr
David J. Mokler
Hyoung-gon Lee
Carla I. Tasca- 1Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Louisville, Louisville, KY, United States
- 2Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME, United States
- 3Department of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, TX, United States
- 4Laboratorio de Neuroquimica 4, Departamento de Bioquimica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
Editorial on the Research Topic
Insights in neuroenergetics, nutrition and brain health: 2023
This Research Topic issue comprises eight contributions, four original research papers, three review articles and one opinion paper. It is a relatively succinct Research Topic of articles that should provide a glimpse into the wide array of new insights into neuroenergetics, nutrition and brain health, an expanding subfield of neuroscience.
In their research article, Mubariz et al. described an investigation into the effect of mutations in the GBA1 gene on the transcription factor EB (TFEB), the main regulator of the autophagy-lysosomal pathway. Their study demonstrated that the mammalian target of rapamycin complex 1 (mTORC1)-TFEB axis is a potential underlying mechanism for the pathogenesis of Parkinson's disease (PD). Yu et al. prospectively investigated the association between plasma urea cycle metabolites and the risk for the cerebrovascular condition known as Moyamoya disease (MMD), which is characterized by the progression of intracranial carotid artery stenosis and an abnormal vascular network in the brain. Their study indicated plasma urea cycle metabolites as potential biomarkers for the risk of MMD. Zhao et al. studied the possible association between selenium intake and migraine, the second most common neurological disorder, in the general American population. Intermittent energy restriction (IER) as an effective strategy of weight loss has gained popularity over the past decade. Li et al. investigated the effect of IER intervention on cerebral regional homogeneity (ReHo) using functional magnetic resonance imaging (fMRI) in 35 obese adults. Xue et al. evaluated the effectiveness of acupuncture as auxiliary treatment when combined with Western medicine therapeutics of epilepsy, reviewing the literature and performing a meta-analysis. Sun et al. reviewed the literature on the topic of mild cognitive impairment (MCI) and its association with liver disease via humoral factors derived from the gastrointestinal tract. They also examined the progress in magnetic resonance imaging (MRI) of the brain performed during MCI associated with liver disease. Zhang et al. examined the role of astrocytic metabolic pathways of carbohydrates, fatty acids and amino acids and changes in these metabolic pathways that offer perspectives on treatment and therapy for various neurological disorders such as depression, Alzheimer's disease and epilepsy. An opinion paper by Schurr uses the accumulated data in recent years to argue for the central role lactate plays in neuroenergetics. Overall, the collection of articles presented in this Research Topic provides insightful original data and review of knowledge on the importance of energy metabolism and nutrition on brain health. Future Research Topics will bring information about this unlimited field of study, contributing to the understanding of brain metabolism under physiological and pathological conditions.
Author contributions
AS: Writing—original draft, Writing—review & editing. DM: Writing—review & editing. H-gL: Writing—review & editing. CT: Writing—review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Publisher's note
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Keywords: brain health, Parkinson's disease, Moyamoya disease, migraine, intermittent energy restriction
Citation: Schurr A, Mokler DJ, Lee H-g and Tasca CI (2023) Editorial: Insights in neuroenergetics, nutrition and brain health: 2023. Front. Neurosci. 17:1331872. doi: 10.3389/fnins.2023.1331872
Received: 01 November 2023; Accepted: 29 November 2023;
Published: 13 December 2023.
Edited and reviewed by: Pierre J. Magistretti, King Abdullah University of Science and Technology, Saudi Arabia
Copyright © 2023 Schurr, Mokler, Lee and Tasca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Avital Schurr, avital.schurr@gmail.com