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CORRECTION article

Front. Neurosci., 13 October 2022
Sec. Brain Imaging Methods
Volume 16 - 2022 | https://doi.org/10.3389/fnins.2022.1025457
This article is part of the Research Topic Image Processing Methods in Animal MRI and their Application to Evaluate Brain Function View all 12 articles

Corrigendum: Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging

This article is a correction to:

  1. Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging

    1. Read original article
\nSurendra MaharjanSurendra Maharjan1Andy P. TsaiAndy P. Tsai2Peter B. LinPeter B. Lin2Cynthia IngrahamCynthia Ingraham2Megan R. JewettMegan R. Jewett1Gary E. Landreth,Gary E. Landreth2,3Adrian L. Oblak,Adrian L. Oblak1,2Nian Wang, Nian Wang1,2*
  • 1Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, United States
  • 2Stark Neurosciences Research Institute, Indiana University, Indianapolis, IN, United States
  • 3Department of Anatomy, Cell Biology and Physiology, Indiana University, Indianapolis, IN, United States

A corrigendum on
Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging

by Maharjan, S., Tsai, A. P., Lin, P. B., Ingraham, C., Jewett, M. R., Landreth, G. E., Oblak, A. L., and Wang, N. (2022). Front. Neurosci. 16:964654. doi: 10.3389/fnins.2022.964654

In the published article, there was an error in Materials and methods, “Histology,” paragraph 1. The incorrect histology protocol was used and the description of the histology (slice thickness, antibody of NeuN, microscope) was therefore incorrect. The paragraph previously stated:

“Histological examinations were performed on the mice brains as previous described (Oblak et al., 2021; Tsai et al., 2021). Coronal 8-μm thick slices were stained immunocytochemically stained for the neuronal nuclear antigen (NeuN) (MAB377, lot 2967854, Millipore, Burlington, MA, United States) and 6E10 staining (BioLegend #803001 in mouse, 1:1000; AB_2564653) for beta-amyloid plaques. The slides were imaged using Axioscop2 FSmot optical microscope with EC PlanNeofluar Zeiss lens at 20× magnification, 0.3 aperture under the same settings and light conditions.”

The corrected paragraph appears below:

“Histological examinations were performed on the mice brains as previous described (Oblak et al., 2021; Tsai et al., 2021). Thirty micron-thick sections were stained to visualize neuronal cell bodies and beta-amyloid plaques using antibodies directed against NeuN (Abcam #ab104225, 1:1000, Boston, MA) and 6E10 (BioLegend #803001, 1:1000). The slides were imaged using Leica DVM6 digital microscope.”

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

Oblak, A. L., Lin, P. B., Kotredes, K. P., Pandey, R. S., Garceau, D., Williams, H. M., et al. (2021). Comprehensive evaluation of the 5xFAD mouse model for preclinical testing applications: A MODEL-AD study. Front. Aging Neurosci. 13:713726. doi: 10.3389/fnagi.2021.713726

PubMed Abstract | CrossRef Full Text | Google Scholar

Tsai, A. P., Lin, P. B.-C., Dong, C., Moutinho, M., Casali, B. T., et al. (2021). INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Neurobiol. Dis. 153:105303 doi: 10.1016/j.nbd.2021.105303

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: Alzheimer's disease, 5xFAD, MRI, DTI, diffusion MRI (dMRI)

Citation: Maharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL and Wang N (2022) Corrigendum: Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging. Front. Neurosci. 16:1025457. doi: 10.3389/fnins.2022.1025457

Received: 22 August 2021; Accepted: 21 September 2021;
Published: 13 October 2022.

Edited and reviewed by: Jie Wang, Wuhan Institute of Physics and Mathematics (CAS), China

Copyright © 2022 Maharjan, Tsai, Lin, Ingraham, Jewett, Landreth, Oblak and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Nian Wang, nianwang@iu.edu

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.