Kate Zara Peters
Fabien Naneix- 1Sussex Neuroscience, School of Psychology, University of Sussex, Falmer, United Kingdom
- 2The Rowett Institute, University of Aberdeen, Aberdeen, United Kingdom
The prefrontal cortex plays a central role in the control of complex cognitive processes including action control and decision making. It also shows a specific pattern of delayed maturation related to unique behavioral changes during adolescence and allows the development of adult cognitive processes. The adolescent brain is extremely plastic and critically vulnerable to external insults. Related to this vulnerability, adolescence is also associated with the emergence of numerous neuropsychiatric disorders involving alterations of prefrontal functions. Within prefrontal microcircuits, the dopamine and the endocannabinoid systems have widespread effects on adolescent-specific ontogenetic processes. In this review, we highlight recent advances in our understanding of the maturation of the dopamine system and the endocannabinoid system in the prefrontal cortex during adolescence. We discuss how they interact with GABA and glutamate neurons to modulate prefrontal circuits and how they can be altered by different environmental events leading to long-term neurobiological and behavioral changes at adulthood. Finally, we aim to identify several future research directions to help highlight gaps in our current knowledge on the maturation of these microcircuits.
Introduction
Successful adaptation to a changing environment requires a complex set of cognitive processes known as executive functions including working memory, attentional processes, behavioral flexibility and decision-making (Rangel et al., 2008). The prefrontal cortex (PFC) plays a key role in regulating these processes by integrating multiple signals and controlling the activity of subcortical circuits (Fuster, 2001; Miller and Cohen, 2001). Altered prefrontal functioning is associated with numerous pathological states including substance use disorders, schizophrenia, eating disorders and obsessive compulsive disorders (Paulus, 2007).
In primates including humans the PFC has been historically defined as the part of the cortex that receives projections from the mediodorsal thalamic nucleus (Rose and Woolsey, 1948). In other mammals, especially rodents, the existence of the PFC and its homology to primate PFC are still debated but it is typically defined as the medial prefrontal cortex (mPFC) and the orbitofrontal cortex (see Uylings et al., 2003; Carlén, 2017; Laubach et al., 2018; Kolk and Rakic, 2022 for a complete review). Prefrontal functions are supported by local microcircuits involving long-range glutamatergic pyramidal neurons and diverse populations of GABAergic interneurons (Seamans and Yang, 2004; Lewis and González-Burgos, 2008). Importantly, prefrontal functions are highly dependent on the influence of neuromodulatory inputs (dopamine, serotonin, acetylcholine, and noradrenaline; Hoover and Vertes, 2007) as well as local endocannabinoid signaling (McLaughlin et al., 2014).
Adolescence is an important developmental period between childhood and adulthood characterized by major behavioral and cognitive changes including increased social interactions, novelty-seeking and risk-taking (Spear, 2000; Ernst et al., 2006; Casey et al., 2008; Walker et al., 2017). At the neurobiological level, adolescence is associated with neurophysiological changes, an increase in white matter volume and inverted U-shaped changes in gray matter volume related to synaptic overproduction and subsequent pruning (Lenroot and Giedd, 2006; Caballero et al., 2016; Drzewiecki and Juraska, 2020; Kolk and Rakic, 2022). These changes are especially marked in the PFC, which may participate to the development of adult-like independent behavior (Ernst et al., 2006; Somerville and Casey, 2010). However, adolescence is also associated with the onset of several major neuropsychiatric disorders (Paus et al., 2008) related with prefrontal dysfunction suggesting that prefrontal circuits may be especially vulnerable to external insults during this stage. Thus, there is a growing interest in gaining a better understanding of the maturation processes of prefrontal microcircuits and how their perturbation may lead to long-lasting neurobiological and cognitive alterations.
In this review, we focus on two important elements of prefrontal circuits: the mesocortical dopamine system and the endocannabinoid system. We outline the unique developmental profiles of these systems during adolescence, how they play essential roles in prefrontal physiology, how they interact to control prefrontal functions and how their alteration can lead to long-term changes at adulthood. Finally, we identify future research directions to highlight gaps in our current knowledge on the maturation of these microcircuits.
Adolescence in humans and rodent models
Adolescence as previously defined is observed in humans but also conserved in other mammals, including rodents (mice and rats) which are commonly used as animal models in neuroscience research (Figure 1A). The exact boundaries of adolescence remain difficult to define. In humans, this is commonly defined as spanning between 12 and 18 years of age. However, these boundaries are not concrete and have been expanded in some studies which report behavioral changes from as early as the age of 10 with the end of adolescent brain maturation occurring as late as the mid-20's (Steinberg, 2005; Ernst et al., 2006; Casey et al., 2008; Blakemore, 2012; Blakemore and Robbins, 2012). Neurocognitive and neurobiological comparisons between primates and rodents have been a somewhat controversial topic in recent years. In one of the most influential reviews on this topic, Spear initially defined adolescence in rodents between post-natal day (PND) 28 and 42 based on the neurobehavioral characteristics reported, however this paper highlighted this may be too restricted (Spear, 2000). Later authors have used diverse age windows to define adolescence and peri-adolescence, based on additional behavioral and neurobiological criteria. Some authors consider rodent adolescence to begin immediately after weaning on PND21 (Schneider, 2008, 2013; Yuan et al., 2015) and to extend all the way until adulthood (PND60-70; Andersen, 2003; McCutcheon and Marinelli, 2009; Brenhouse and Andersen, 2011; Walker et al., 2017). More recently and based on changes in prefrontal anatomy, Caballero and Tseng have classified adolescent periods of development and vulnerability into early (PND35-40), mid (PND40-50), and late (PND50-60) adolescence (Caballero et al., 2016). In the rest of the manuscript, we will use the term adolescence to refer to the broad period between weaning (PND21) and adulthood (PND60-70) in rodents.
Figure 1. (A) Timing of adolescence in humans (top) and rodents (bottom). Adolescence and peri-adolescence are defined as beginning around the age 10 years and continuing until the mid-20's in humans and from post-natal day (PND) 21 to PND 50-60 in mice and rats. (B) Maturation of prefrontal dopamine (DA) and endocannabinoid systems across development. Schematic shows density of prefrontal anandamide (purple), dopamine (DA) tissue concentration (orange), and DA fibers (black) steadily increase from childhood to adulthood. Meanwhile, both CB1 (blue) and dopamine receptors (green) present a transient peak of expression in the prefrontal cortex during early adolescence, paralleled with similar changes in the activity of dopamine neurons in the VTA (red). Finally 2-AG levels (cyan) transiently decreases compared to childhood before returning to stable adult levels.
An important point to note is that although puberty is a part of adolescence, it does not itself fully define adolescence. Puberty is defined as sexual maturity resulting from changes in the secretion of gonadal hormones. In humans the onset of puberty (~10 years old) is often considered as the onset of adolescence, but this can vary depending on sex, gender, ethnicity and socioeconomical status. In rodents, these two phenomena are clearly distinct between sexes. In females, vaginal opening and first ovulation occur early during adolescence (PND30-40), whereas in males increased testosterone and preputial separation occur during mid adolescence (PND40-45; Schneider, 2008; Delevich et al., 2021). Puberty likely contributes to the development of prefrontal anatomy and functions which we will briefly discuss later.
The mesocortical dopamine pathway: A uniquely late maturing system
The dopamine system is a central actor in the modulation of behavioral control and conveys various signals related to prediction error, motivation and event salience (Floresco and Magyar, 2006; Berridge, 2007; Schultz, 2007; Wickens et al., 2007; Bromberg-Martin et al., 2010; Berke, 2018). It presents a uniquely late development during postnatal life especially within prefrontal regions, which appears to be fundamental for normal cognitive development (Spear, 2000; Ernst et al., 2006; Somerville and Casey, 2010; Sturman and Moghaddam, 2011; Walker et al., 2017).
The mesocortical dopamine system
Dopaminergic cells mainly located in the midbrain differentially innervate the dorsal striatum (nigrostriatal pathway), the nucleus accumbens (mesolimbic pathway), and prefrontal regions (mesocortical pathway) which we will focus on in the present review (for recent reviews on the anatomical organization of dopamine pathways see Björklund and Dunnett, 2007; Lammel et al., 2014; Morales and Margolis, 2017). The mesocortical pathway originates from the medial part of the ventral tegmental area (VTA) and is comprised of dopamine neurons (30–40%) but also an important fraction of GABAergic and glutamate neurons (Morales and Margolis, 2017). In primates, dopamine neurons innervate prefrontal and sensorimotor cortical regions whereas in rodents this is limited to the mPFC, the agranular insular and the perirhinal cortices (Berger et al., 1991). Dopamine innervation is stronger in ventral parts of the mPFC (prelimbic cortex or Brodmann area 32 / infralimbic cortex or Brodmann area 25; Laubach et al., 2018), and is especially observed in deep cortical layers (layers V–VI; Van Eden et al., 1987; Heidbreder and Groenewegen, 2003). In contrast to the mPFC, rodent orbitofrontal regions are weakly innervated by dopamine neurons. Dopamine neurons rarely send collateral projections to other regions, meaning that mesocortical dopamine neurons represent a distinct population compared to mesolimbic neurons (Fallon, 1988; Beier et al., 2015). Dopamine neurons display two characteristic activity patterns: (1) a “tonic” low frequency mode (2–5 Hz) maintaining basal levels of dopamine in downstream targets and (2) a “phasic” mode with short high frequency (10–20 Hz) bursts transiently increasing dopamine release (Grace and Bunney, 1984a,b; Floresco et al., 2003; Lapish et al., 2007; Rice et al., 2011). This burst firing is especially observed in response to relevant environmental stimuli (Schultz, 2007; Bromberg-Martin et al., 2010). The exact functions of these different modes of dopamine signaling are still debated but through its actions at downstream targets and within local microcircuits, dopamine guides, invigorates and updates complex behaviors (Niv, 2007; Schultz, 2007; Bromberg-Martin et al., 2010; Salamone and Correa, 2012; Berke, 2018).
Mesocortical dopamine neurons respond to both appetitive (Hernandez and Hoebel, 1990; Ahn and Phillips, 1999; Bassareo et al., 2002; St Onge et al., 2012; Ellwood et al., 2017) and aversive stimuli (Abercrombie et al., 1989; Mantz et al., 1989; Vander Weele et al., 2018). Moreover, they have unique properties compared to other dopamine projections including low levels of dopamine transporter DAT and D2 autoreceptors associated with higher basal frequency (Sesack et al., 1998; Lammel et al., 2008). These properties result in different kinetics of dopamine signaling compared to subcortical regions (Garris and Wightman, 1994; Cass and Gerhardt, 1995; Vander Weele et al., 2018). Prefrontal neurons also directly regulate other dopamine circuits by exciting VTA mesocortical and mesolimbic neurons (Carr and Sesack, 2000; Heidbreder and Groenewegen, 2003; Gabbott et al., 2005; Beier et al., 2015) and by modulating dopamine release within subcortical regions including the nucleus accumbens (Taber et al., 1995; Karreman and Moghaddam, 1996; Rice et al., 2011; Nolan et al., 2020).
With its unique characteristics, the mesocortical dopamine pathway plays a key role in prefrontal function (Fuster, 2001; Miller and Cohen, 2001). Current theories postulate a “dual-state” function of prefrontal dopamine signaling. Tonic dopamine levels may act to maintain goal representation and adapted behavioral strategies by stabilizing the activity of specific prefrontal neuronal ensembles. Phasic dopamine release occurs in response to relevant stimuli and would gate new afferent signals from cortical and subcortical regions to update goal representations and behavioral strategies (Montague et al., 2004; Seamans and Yang, 2004; Daw et al., 2006; Durstewitz and Seamans, 2008; Ellwood et al., 2017).
Development of the dopamine mesocortical pathway in early life and adolescence
In rodents, the first mesencephalic dopamine neurons appear during embryonic life (E12) and immediately start to extend projections to the developing telencephalic regions (Riddle and Pollock, 2003; Van den Heuvel and Pasterkamp, 2008; Islam et al., 2021). Dopamine fibers are detected in the striatum and the nucleus accumbens at E15-E17 (Voorn et al., 1988). The nigrostriatal and mesolimbic dopamine pathways end their development during the first postnatal week (Kalsbeek et al., 1988; Voorn et al., 1988). Dopamine fibers appear in the mPFC shortly after from E19 and continue to develop during postnatal life (Van Eden et al., 1987; Kalsbeek et al., 1988). In contrast to other neuromodulatory systems in the mPFC, such as noradrenaline or serotonin (Levitt and Moore, 1979; Lidov et al., 1980; Lambe et al., 2000; Naneix et al., 2012), the mesocortical dopamine pathway has a uniquely protracted maturation (Figure 1B). The density of dopamine fibers continues to increase until adulthood in rodents and primates in all mPFC subregions (Kalsbeek et al., 1988; Rosenberg and Lewis, 1994; Benes et al., 1996; Naneix et al., 2012; Hoops and Flores, 2017; Willing et al., 2017; Reynolds and Flores, 2021). This late development parallels increased basal dopamine levels in the mPFC during adolescence and decreased levels of dopamine metabolites (Nomura et al., 1976; Naneix et al., 2012) suggesting a broad increase in dopamine availability and action in prefrontal regions from childhood to adulthood. This is associated with an increase in the proportion of prefrontal cells, especially GABA neurons, in contact with dopamine fibers but also in the absolute number of dopamine varicosities per neuron (Benes et al., 1996), suggesting an increased dopaminergic modulation of these cells.
The continuous growth of dopamine fibers in prefrontal regions likely involves a combination of continued long-range axon growth from the VTA and increased sprouting from dopamine axons already present in the mPFC. There is now considerable evidence that these processes are under the control of several extracellular guidance cues including ephrins, semaphorins, netrins or slits during embryonic and postnatal stages (Van den Heuvel and Pasterkamp, 2008; Brignani and Pasterkamp, 2017; Hoops and Flores, 2017; Islam et al., 2021). The development of the mesocortical dopamine pathway during adolescence seems to be especially dependent of the Netrin-1/DCC (Hoops and Flores, 2017). Dopamine neurons express high levels of the Netrin-1 receptor during embryonic and early post-natal life (pre-weaning) which decrease toward adulthood (Manitt et al., 2010). A proportion of dopamine axons innervating the mPFC at adulthood are still growing through the nucleus accumbens during adolescence (Reynolds et al., 2015, 2018; Reynolds and Flores, 2021). This process is under the control of the Netrin-1 receptor and DCC. Reduced DCC expression in dopamine neurons increases dopamine innervation and dopamine levels in the mPFC (Manitt et al., 2011, 2013; Reynolds et al., 2018). These results suggest that high DCC-expressing dopamine neurons are attracted by brain regions expressing low levels of Netrin-1 such as the nucleus accumbens thus forming the mesolimbic pathway early in development (Manitt et al., 2011). In contrast, prefrontal neurons express high levels of Netrin-1 which attract a specific population of dopamine neurons expressing low levels of DCC during adolescence (Flores et al., 2005; Grant et al., 2007, 2009; Manitt et al., 2011; Reynolds et al., 2018). In addition to guidance cues the refinement of the dopamine system during adolescence may be under the influence of glial cells which contribute to synaptic development and pruning (for review see Béchade et al., 2013; Kettenmann et al., 2013; Brenhouse and Schwarz, 2016). Recent findings show that the downregulation of dopamine receptors in the nucleus accumbens during early adolescence is dependent of microglial activation, especially in males (Kopec et al., 2018). A similar mechanism within the mPFC remains to be demonstrated but microglia cells are already known to regulate the pruning of mPFC glutamatergic synapses during adolescence (Mallya et al., 2019; Blagburn-Blanco et al., 2022).
In addition to the growth of dopamine fibers the activity of dopamine cells also undergoes important changes during adolescence. In vivo and ex vivo recordings have revealed that VTA dopamine neurons in rats have higher tonic firing rates during adolescence compared to adulthood, peaking during late adolescence (PND40-50). In addition, although adolescent rats have a similar proportion of phasic activity episodes, these are consistently longer compared to those of adults (McCutcheon and Marinelli, 2009; McCutcheon et al., 2012; Marinelli and McCutcheon, 2014; but see Kim et al., 2016; McCane et al., 2021). It is currently unknown whether these age-related changes are specific to different defined neuronal populations or pathways. However, in vivo study in mice has demonstrated that the increase in dopamine neuron activity during adolescence may participate specifically to the development of the mesocortical pathway as the phasic activation of dopamine neurons in adolescents, but not in adults, promotes the formation of new synaptic boutons on mesocortical neurons (Mastwal et al., 2014). This is consistent with the role of dopamine in synaptogenesis also demonstrated in vitro (Parish et al., 2001; Fasano et al., 2008, 2010).
At the postsynaptic level, both PFC pyramidal glutamate neurons and GABA interneurons express dopamine D1-like (D1, D5) and D2-like (D2, D3, D4) receptors (Berger et al., 1991; Gaspar et al., 1995; Le Moine and Gaspar, 1998). Dopamine receptor expression during adolescence seems to present a complex reorganization in the cortex. However, data exploring this has produced somewhat conflicting and inconclusive results. For example, autoradiography studies in rats have shown either a steady increase in the expression of D1- and D2-like receptors (Tarazi and Baldessarini, 2000) or a binding peak at weaning followed by a decrease afterwards (Leslie et al., 1991). However immunohistochemistry (Andersen et al., 2000; Brenhouse et al., 2008; Brenhouse and Andersen, 2011) or qPCR studies (Naneix et al., 2012) have shown that the expression of dopamine receptors peaks during mid-adolescence, suggesting a short window of overexpression followed by pruning of dopamine synapses during late adolescence/early adulthood which may be related to the increased activity of dopamine neurons during the same period (McCutcheon and Marinelli, 2009; McCutcheon et al., 2012; Figure 1B). Recent advances in single cell RNA sequencing may clarify this picture by potentially showing different patterns of maturation within mPFC neuronal populations (Bhattacherjee et al., 2019; Tiklová et al., 2019).
The endocannabinoid system and prefrontal circuits during adolescence
The endocannabinoid system
Together with the dopamine system, the endocannabinoid (eCB) system is another central neuromodulator of executive functions (Egerton et al., 2006; Pattij et al., 2008) in adults and shares a similar late maturation during adolescence with the dopamine system (Caballero et al., 2016). In the following sections we will discuss how endocannabinoids and their endogenous receptors change across adolescence and how this influences the maturation of the PFC.
The two main endocannabinoids are 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA or anandamide; Mechoulam et al., 1995; Sugiura et al., 1995). They both bind to two key G-protein coupled receptors (GPCRs): cannabinoid receptor 1 (CB1)—expressed throughout the central nervous system (Herkenham et al., 1990; Mechoulam et al., 1995)—and cannabinoid receptor 2 (CB2) expressed predominantly in immune cells but also found in some neurons and glia (Atwood and Mackie, 2010; Zhang et al., 2014). We will focus here on the CB1 receptor due to its ubiquitous expression throughout the brain including the prefrontal cortex (Herkenham et al., 1990; Marsicano and Lutz, 1999) and its role in PFC development.
CB1 receptors are coupled to inhibitory G-proteins (Gi/o proteins) and their activation reduces cAMP levels, decreasing cAMP-dependent protein kinase activity (Howlett and Mukhopadhyay, 2000; Howlett, 2002). This induces the activation of A-type potassium channels, the inhibition of voltage-gated calcium channels and the disruption of neurotransmitter vesicles (Lovinger, 2008), which decreases the probability of neurotransmitter release. Unlike classical modulatory neurotransmitters which are stored in vesicles, endocannabinoids are synthesized and released de novo in times of sustained neuronal activity (Howlett and Mukhopadhyay, 2000; Freund et al., 2003) acting on presynaptic terminals (Wilson and Nicoll, 2001; Kreitzer and Regehr, 2002). This retrograde action allows neurons to filter and select afferent inputs via negative feedback. The principle psychoactive ingredient in cannabis, Δ9- tetrahydrocannabinol (THC), is a potent CB1 agonist (Gaoni and Mechoulam, 1964; Huestis et al., 2001).
Both 2-AG and AEA are derived from poly-unsaturated fatty acids but have distinct synthesis and metabolic pathways (Ueda et al., 2010; Ueda and Tsuboi, 2012). 2-AG is a major product of the phospholipase Cβ - diacylglycerol lipase pathway synthesized post-synaptically following sustained depolarization and by the subsequent increased calcium influx following activation of voltage-gated Ca2+ channels (Kano et al., 2009). 2-AG is metabolized by monoacylglycerol lipase (MAGL) localized mainly with pre-synaptic CB1 receptors (Häring et al., 2012). AEA synthesis on the other hand is a relatively minor biproduct of fatty acylethanolamine (N-acylethanolamines) species production triggered by increased intracellular calcium or cAMP levels in postsynaptic neurons (Bara et al., 2021). AEA is metabolized by fatty acid amide hydrolase (FAAH) localized post-synaptically to provide feedback inhibition (Häring et al., 2012).
Beyond their different synthetic and metabolic pathways, 2-AG and AEA also differ in terms of their pharmacological and functional actions via CB1 receptors. Pharmacologically 2-AG is a full agonist of the CB1 receptor, whereas AEA is a partial agonist (Sugiura et al., 1995, 2006). Despite binding to CB1 receptors with high affinity, AEA induces relatively poor intracellular signal transduction (Hillard et al., 1995). The slower time course of AEA's action makes it a good candidate for a tonic signal (Hill and Tasker, 2012) and thus AEA is implicated in long-term plasticity (Mackie, 2006). 2-AG on the other hand has a relatively low binding affinity for CB1 receptors but produces a much more robust intracellular response (Hillard et al., 1995). These dynamics combined with 2-AG release following sustained depolarization show a more characteristically phasic signal seen in shorter, activity-dependent synaptic plasticity (Lu and Mackie, 2016). In addition, 2-AG levels are generally several orders of magnitude higher than AEA levels in rodent brain tissue (Bisogno et al., 1999; Ueda and Tsuboi, 2012) which may be related to their different synthesis pathways.
Whilst we focus this review on the function and dysfunction of the eCB system in shaping the PFC through actions at CB1 receptors, it is important to consider that endocannabinoids also interact with other receptors and systems. Whilst predominantly expressed in peripheral tissues CB2 receptors are expressed in some microglia within the brain and their activation may have important effects we do not fully understand (Cabral et al., 2008). In addition, eCBs can activate or facilitate the activation of other receptors. For example, AEA is a TRPV1 receptor agonist and 2-AG can potentiate GABA-A receptors independently of CB1 receptor effects (Piscitelli and Di Marzo, 2012). In fact, eCB signaling has been shown to engage as many as 12 different receptors and involve many biosynthetic and degradative enzymes, transporters and other proteins diversifying the ways eCB signaling may impact local brain circuits (for a comprehensive discussion of the complex interactions between endocannabinoids and other receptors, transporters, and enzymes see Maccarrone, 2020).
The eCB system in the developing brain
The CB1 receptor is the most abundant GPCR in the brain and the eCB system is uniquely positioned to have large scale influence on developing brain circuits. Our current understanding of the functioning and role the eCB system is still relatively new but we know this system is fundamentally important in all phases of brain development especially in controlling long-range axonal guidance and patterning of synaptic contacts (Berghuis et al., 2007; Harkany et al., 2007, 2008; Maccarrone et al., 2014; Bara et al., 2021). In cortical regions CB1 receptors are expressed at higher levels in GABAergic interneurons than in glutamatergic neurons with a higher expression in the PFC compared to motor and sensory cortices (Marsicano and Lutz, 1999). PFC CB1 expression in rodents peaks to its maximal density in early adolescence (Meyer et al., 2018), and then declines into adulthood (Figure 1B; Berrendero et al., 1999; Ellgren et al., 2008; Heng et al., 2011a; Peters et al., 2021c).
During adolescence 2AG and AEA levels also fluctuate. Within the PFC, AEA steadily increases from early to late adolescence, with concentrations reaching three times higher levels in late versus early adolescence before reaching stable levels into adulthood (Ellgren et al., 2008; Tirado-Muñoz et al., 2020). PFC 2-AG levels markedly decrease from early to late adolescence before stabilizing in adulthood (Ellgren et al., 2008; Rubino et al., 2015; Bara et al., 2021). These changes are accompanied by complementary changes in the activity of FAAH and MAGL (Long et al., 2012). Increased FAAH levels in adolescence may reflect in particular the tighter regulation of AEA during this key developmental period (Long et al., 2012).
Changes in the anatomical organization of the endocannabinoid system during adolescence are associated with important functional changes in synaptic plasticity which may also play an important role in long-range axonal pathfinding and patterning of synaptic contacts, both essential processes for prefrontal development (Berghuis et al., 2007; Maccarrone et al., 2014).
Sex differences in the developing dopamine and endocannabinoid prefrontal systems
There are important sex differences in cortical development in humans, most prominent is the faster maturation of the cortex in females compared to males (Mutlu et al., 2013) as well as early differences in functional connectivity and sex specific age-related changes in resting state activity (Zuo et al., 2010). Similar sex differences are also reported in subcortical regions. Striatal development also occurs faster in females with striatal volume stabilizing around early adolescence, whereas in males this continues to develop until early adulthood (Raznahan et al., 2014; Hammerslag and Gulley, 2016). In rodents, key sex differences have been also reported in the development of the prefrontal cortex (Drzewiecki and Juraska, 2020). Sex and the onset of puberty, with changes in gonadal hormones during adolescence, may be critical factors in the late maturation of dopamine and endocannabinoid systems (Becker and Chartoff, 2019; Zachry et al., 2021). However, until recently most of the data from animal models has come from studies in males.
In the dopamine system there are crucial anatomical and functional sex differences in adulthood including a higher proportion of dopamine neurons in the VTA of female rodents and variation of striatal dopamine concentration with the estrous cycle through the expression of estrogen receptors in both dopamine and striatal GABAergic striatal neurons (for a recent complete review see Zachry et al., 2021). Within the mesocortical pathway in particular, female rats exhibit a higher proportion of dopamine neurons (tyrosine hydroxylase expressing cells) compared to males (>50 vs. 30%; Kritzer and Creutz, 2008). Estrogen receptors are also expressed at both presynaptic and postsynaptic level in the prefrontal cortex (Almey et al., 2015) and in different proportion between males and females (Kritzer and Creutz, 2008) but sex- and estrous cycle-related modulation of dopamine signaling in this region remains poorly understood. So far, studies have found no substantial sex differences in the time course of the development of mesocortical DA innervation (Willing et al., 2017). However, gonadectomy of male rats at adulthood or during the perinatal period alters the organization of the mesocortical dopamine pathway (Kritzer, 1998; Kritzer et al., 1999), suggesting there is a role of puberty in this maturation. Furthermore, there are clear age- and sex-dependent differences in subcortical dopamine release and reuptake in rats in adolescence and adulthood (Pitts et al., 2020). These differences remain to be investigated in the prefrontal cortex.
Consistent with the general earlier maturation of the female brain the increases in CB1 receptor density seen in adolescence begin earlier in female rodents compared to males (de Fonseca et al., 1993). The expression of CB1 receptors also varies across the estrous cycle in female mice and rats, with CB1 mRNA transcripts highest in diestrus and lowest on estrus (González et al., 2000). Levels of AEA are generally higher in female rats and again these fluctuate with the estrous cycle. In contrast, 2-AG does not seem to differ between males and females or as a function of the estrous cycle. In addition, eCB signaling can modulate gonadal hormones in both humans and rodents (Meyer et al., 2018). The relationship between puberty, sex hormones, neuromodulators and the maturation of brain functions during adolescence remains poorly understood and certainly requires a more in-depth investigation (Shansky and Murphy, 2021).
Dopamine and endocannabinoid modulation of prefrontal circuits in the emergence of prefrontal functions during adolescence
Prefrontal circuits play a central role in action control including working memory processes (Goldman-Rakic et al., 2000; Seamans and Yang, 2004), goal-directed behaviors (Balleine and O'Doherty, 2010; Coutureau and Parkes, 2018; Turner and Parkes, 2020), response inhibition (Winstanley et al., 2006; Turner and Parkes, 2020), and behavioral flexibility (Floresco and Magyar, 2006). In adults, prefrontal dopamine (Floresco and Magyar, 2006; Winstanley et al., 2006) and endocannabinoid (Egerton et al., 2006; Pattij et al., 2008; McLaughlin et al., 2014; Gremel et al., 2016) signaling are important modulators of these executive functions. Several studies have reported alterations of these processes in adolescent rodents including adaptation to action-outcome contingency changes (Naneix et al., 2012, 2013), behavioral inhibition (Andrzejewski et al., 2011), attentional control (Burton and Fletcher, 2012), impulsivity (Doremus-Fitzwater et al., 2012), or behavioral extinction (Sturman et al., 2010). Conversely, adolescent rodents exhibit an increased sensitivity to rewards (Wilmouth and Spear, 2009; Friemel et al., 2010; Doremus-Fitzwater et al., 2012), environmental stimuli driving reward-seeking responses and motivated behaviors (Burton et al., 2011; Marshall et al., 2020), and impulsivity (Adriani and Laviola, 2003). These behavioral changes appear to be essential to the transition from childhood to adulthood by increasing exploration and novelty seeking but may also drive risk-taking behaviors.
Prefrontal functions and physiology are the results of a complex balance between excitatory (glutamatergic) and inhibitory (GABAergic) transmission regulated by different neuromodulation system including the dopamine and endocannabinoid systems (O'Donnell, 2011; Caballero et al., 2016; Figure 2). In the following sections, we will focus on how developmental changes in prefrontal dopamine and eCB systems represent an important mechanism in the emergence of PFC functions by increasing both the stability of PFC microcircuits and the timed filtering of subcortical inputs essential to either maintain or switch behavioral strategies adapted to changing environments (Simon and Moghaddam, 2014; Reichelt, 2016).
Figure 2. Adolescent changes in the modulation of prefrontal circuits by dopamine and endocannabinoids. (1) During adolescence, dopamine (DA, orange) increases the excitability of prefrontal GABAergic interneurons (blue) solely through D1 actions. At adulthood, dopamine facilitates interneurons excitability through both D1 and D2 receptors, which may change GABAergic control of pyramidal neuron (PN) activity. (2) Dopamine actions through D1 receptors enhance glutamatergic NMDA signaling on glutamate (Glu, pink and orange) neurons. This effect is more robust during late adolescence/adulthood, allowing the emergence of persistent depolarizations of pyramidal neurons (PN, orange). (3) eCB retrograde control (green) of glutamate transmission decreases between adolescence and adulthood, likely due to changes in expression levels of CB1 receptors. (4) At adulthood, the combined action of dopamine on D2 receptors and eCB signaling control the activity of plasticity of GABAergic synapses on PN. Changes in this process during adolescence remain to be demonstrated. (5) PN controls the activity of subcortical circuits. Within the VTA for instance, both PN glutamate transmission and local GABAergic transmission control the activity of DA neurons and DA release. Developmental changes in eCB signaling through the expression of CB1 receptors on PN and GABAergic neurons may change this regulation.
Dopamine and endocannabinoid modulation of prefrontal glutamatergic neurons
Both dopamine and endocannabinoids modulate the activity of pyramidal glutamate neurons and prefrontal glutamatergic plasticity. In adults, dopamine's action on prefrontal circuits is highly dependent of the excitability state of pyramidal neurons and interneurons. Low dopamine levels maintain prefrontal networks, mainly through actions on GABAergic interneurons and D2 receptors. Increases in dopamine levels during phasic activity recruits D1 receptors (Montague et al., 2004; Seamans and Yang, 2004; Durstewitz and Seamans, 2008) required for prefrontal functions such as executive functions (Floresco and Magyar, 2006; Floresco and Jentsch, 2011) and appetitive learning (Baldwin et al., 2002). Dopamine D1 signaling interacts with glutamatergic N-methyl-D-aspartate (NMDA) receptor signaling through D1-dependent mechanisms to induce long-lasting plateau depolarizations (up-state) of pyramidal cells (Tseng and O'Donnell, 2005). Similarly, CB1-dependent eCB signaling regulates prefrontal glutamatergic activity through depolarization-induced suppression of excitation process (Auclair et al., 2000; Kreitzer and Regehr, 2002; Fortin and Levine, 2007; Lovinger, 2008) and long-term depression in deep cortical layers (V–VI; Lafourcade et al., 2007).
As prefrontal D1 expression levels change during adolescence (Leslie et al., 1991; Tarazi and Baldessarini, 2000; Brenhouse et al., 2008; Naneix et al., 2012), ex vivo studies also showed that D1-NMDA interactions emerge during adolescence (Tseng and O'Donnell, 2005; Heng et al., 2011b; Flores-Barrera et al., 2014; Caballero et al., 2016). Despite important anatomical changes on both glutamatergic projections from the amygdala and the hippocampus to the PFC (Cunningham et al., 2002; Johnson et al., 2016; Calabro et al., 2020), only the latter presents a delayed functional maturation during adolescence (Caballero et al., 2014b; Flores-Barrera et al., 2014). Long-term potentiation (LTP) of hippocampal-prefrontal synapses on pyramidal only appear after PND50 in relationship with changes in the expression of GluN2B subunit composition of NMDA receptors. This process parallels the decrease of CB1-related inhibition of glutamatergic transmission (Heng et al., 2011a; Caballero et al., 2016) which may facilitate excitatory transmission from the PFC to subcortical circuits. Interestingly, anatomical studies have shown important changes in D1 expression levels in prefronto-accumbens neurons which may underlie increased incentive salience in response to environmental cues seen in adolescents (Brenhouse et al., 2008; Sonntag et al., 2014).
Dopamine and endocannabinoid modulation of prefrontal GABAergic neurons
As for glutamatergic signaling, prefrontal GABAergic transmission is also still undergoing important developmental changes during adolescence. Previous studies demonstrated a progressive increase in the expression levels of calcium binding proteins parvalbumin and a parallel decrease in the expression of calretinin (Caballero et al., 2014a), increasing the proportion of fast-spiking interneurons. This process is dependent on NMDA glutamatergic transmission onto GABAergic interneurons (Flores-Barrera et al., 2014; Caballero et al., 2016; Bogart and O'Donnell, 2018) which may be related to the continuous development of projections from the hippocampus and the amygdala during this period (Cunningham et al., 2002; Johnson et al., 2016; Calabro et al., 2020).
Before adolescence, dopamine facilitates GABAergic transmission by increasing GABA interneurons excitability only through D1 receptor signaling (Gorelova et al., 2003; Tseng et al., 2006). Intriguingly, during late adolescence (PND50), dopamine increases GABA neurons excitability through both D1 and D2 signaling (Tseng et al., 2006; Tseng and O'Donnell, 2007; Caballero et al., 2016). This process is still poorly understood but may involve changes in the expression of D2 receptors and their signaling through β-arrestins which are able to enhance firing of parvalbumin interneurons in the cortex (Urs et al., 2016).
Less is known about the developmental changes of eCB-dependent regulation of GABAergic transmission. In adults, CB1 signaling suppresses GABA release onto glutamatergic cells (Chiu et al., 2010; Hill et al., 2011) and drives depolarization-induced suppression of inhibition at these synapses (Kiritoshi et al., 2013). Moreover, CB1 receptors also colocalize with dopamine D2 receptors on GABA cells, participating in the establishment of long-term depression of GABA synapses (Chiu et al., 2010). It is currently unknown if the changes in prefrontal CB1 receptor expression during adolescence follow the same pattern in glutamatergic and GABAergic neurons (Berrendero et al., 1999; Ellgren et al., 2008; Meyer et al., 2018; Peters et al., 2021c). As for glutamatergic pyramidal neurons, potential changes in CB1 and dopamine modulation of prefrontal GABAergic transmission may contribute to the establishment of excitation/inhibition balance, increasing the selection of specific inputs, decreasing the signal-to-noise ratio and refining prefrontal processing (Montague et al., 2004; Seamans and Yang, 2004; Durstewitz and Seamans, 2008; O'Donnell, 2011; Caballero et al., 2016).
Beyond prefrontal microcircuits: Dopamine and endocannabinoid modulation of prefrontal signaling to subcortical regions
Changes in the prefrontal endocannabinoid system during adolescence may also impact the dopamine system and dopamine signaling in prefrontal subcortical targets, modulating dopamine-related behaviors such as reward prediction error, learning, motivation and event salience (Floresco and Magyar, 2006; Berridge, 2007; Schultz, 2007; Wickens et al., 2007; Bromberg-Martin et al., 2010; Berke, 2018).
In the VTA, dopamine neurons synthesize and release eCBs but do not express CB1 receptors (Julian et al., 2003), VTA eCBs act on local GABA interneurons as well as on GABA and glutamate terminals (Szabo et al., 2002; Melis et al., 2004; Riegel and Lupica, 2004; Wang et al., 2015). This results in the indirect disinhibition of dopamine neurons and the increase of dopamine release in terminal regions including the nucleus accumbens (Cheer et al., 2000, 2007; Oleson et al., 2012; Zlebnik and Cheer, 2016; Covey et al., 2017; Peters et al., 2021a,b) and the prefrontal cortex (Pistis et al., 2002). As in cortical regions, CB1 receptor expression in the VTA increases during early adolescence (PND 40) before decreasing to reach adult levels (de Fonseca et al., 1993) but the neuronal specificity of such changes remains unknown. This may be related to changes in CB1 levels on prefrontal glutamatergic terminals in the VTA controlling the activity of dopamine neurons (Carr and Sesack, 2000; Heidbreder and Groenewegen, 2003; Gabbott et al., 2005; Beier et al., 2015). These complex changes may represent an important mechanism underlying developmental changes in VTA responses to rewarding and aversive environmental stimuli (Kim et al., 2016; McCane et al., 2021) and dopamine-related behaviors (Spear, 2000).
Prefrontal glutamatergic neurons also strongly project to striatal regions (Vertes, 2004; Gabbott et al., 2005) to modulate action control processes (Alexander et al., 1986; Haber, 2003; Voorn et al., 2004). In the nucleus accumbens, cortical glutamatergic terminals control the activity of GABAergic medium spiny neurons (Surmeier et al., 2011) but also modulate local dopamine release through indirect actions on cholinergic interneurons (Cachope et al., 2012; Mateo et al., 2017). In adults, this cortical control of mesolimbic dopamine signal is dependent on CB1 receptors expressed on glutamatergic terminals. Combined with changes in the expression of dopamine D1 receptors by prefronto-accumbens neurons (Brenhouse et al., 2008; Sonntag et al., 2014), changes in CB1 expression in the same neurons may strongly change dopamine release in subcortical regions between adolescents and adults, impacting the control of motivated behaviors. Accordingly, ex vivo and in vivo studies have reported age-related changes in dopamine release in different striatal regions (Matthews et al., 2013; Pitts et al., 2020) and in striatal neuronal responses during instrumental and Pavlovian tasks (Galiñanes et al., 2009; Sturman and Moghaddam, 2012) which may also underlie enhanced reward sensitivity and executive functions deficits during adolescence.
Vulnerability of prefrontal circuits during adolescence
Unfortunately, the late maturation of prefrontal circuits and the associated behavioral changes also creates a window of vulnerability to external insults which may have long-lasting deleterious impact on brain functions. Accordingly, adolescence is the period of life associated with the onset of numerous neuropsychiatric disorders in humans, such as schizophrenia, substance abuse or eating disorders (Paus et al., 2008). As previously stated, adolescents and the adolescent brain are especially sensitive to valence-based stimuli such as drugs of abuse, palatable foods or stressful experience (Spear, 2000; Andersen, 2003; Crews et al., 2007; Reichelt, 2016; Reichelt and Rank, 2017). In this last section, we will focus on two specific examples to illustrate how specific exposure during adolescence may impact prefrontal dopamine and eCB systems and related functions: the effects of cannabis (or CB1 agonists) and the effects of palatable foods.
Impact of adolescent cannabinoid exposure on prefrontal circuits and functions
Cannabis is one of the most commonly used drugs of abuse, especially amongst adolescents (Miech et al., 2020). THC, the principal psychoactive constituent of cannabis, is a potent CB1 agonist (Gaoni and Mechoulam, 1964; Huestis et al., 2001). We do not fully understand how adolescent use in particular impacts the developing brain, however there is emerging evidence that altering the eCB system through such external insults may have important consequences especially at the prefrontal level (Schneider, 2008; Bara et al., 2021). Accordingly, numerous studies in humans and animal models report associations between adolescent cannabis exposure and increased risk of psychiatric conditions which a emerge in adolescence including psychosis, mood disorders and substance use disorders (Laviolette and Grace, 2006; Rubino et al., 2012; Renard et al., 2016).
Chronic CB1 agonist treatment in adolescent animals causes alterations in multiple PFC dependent behaviors, including anxiety (O'Shea et al., 2004), short- and long-term spatial and working memory (Rubino et al., 2009; Renard et al., 2013), motivational and emotional processes (Schneider and Koch, 2003), social behaviors (Schneider et al., 2008), and drug-seeking responses (Ellgren et al., 2007; Higuera-Matas et al., 2008). These alterations are specific to adolescence and are not observed when agonists are administered in adulthood. Importantly, the functioning and vulnerability of the eCB system presents important sex-differences that we do not discuss here (see Ginder et al., 2022 for a complete review of this topic) but which may play a key role in normal and pathological development during adolescence and puberty.
These behavioral phenotypes are associated with profound anatomical and functional alterations of prefrontal circuits (Rubino et al., 2015). These include alterations in mPFC CB1 receptor density and impaired eCB-mediated long-term depression (LTD) of prefrontal excitatory transmission (Rubino et al., 2015; Cuccurazzu et al., 2018). These changes are associated with an increased expression of GluA1 and GluN2B subunits in AMPA and NMDA receptors respectively (Rubino et al., 2015), altering the normal development of PFC glutamatergic transmission (Lovelace et al., 2015; Rubino et al., 2015). Interestingly, these effects are reversed by enhancing AEA levels at adulthood (Cuccurazzu et al., 2018), highlighting the importance of eCB signaling in normative prefrontal development and function.
In addition to its action on prefrontal glutamatergic transmission, there is emerging evidence that prefrontal GABA interneurons may be especially vulnerable to adolescent THC (or synthetic agonist) exposure (Cass et al., 2014; Renard et al., 2018; Peters et al., 2021c). Adolescent, but not adult, exposure to the synthetic CB1 agonist WIN55,212-2 decreases prefrontal GABA signaling resulting in dysregulation of cortical oscillatory activity (Cass et al., 2014; Renard et al., 2017). Conversely, activating prefrontal GABA-A receptors restores behavioral and dopaminergic abnormalities observed following adolescent THC exposure (Renard et al., 2017). Reduced prefrontal GABAergic transmission is associated with hyperdopaminergic state and alterations of prefrontal cortex-related behaviors (Yee et al., 2005; Enomoto et al., 2011), mimicking key behavioral alterations observed for instance in schizophrenia (Carlsson et al., 1997; O'Carroll, 2000; Nakazawa et al., 2012).
Adolescent cannabis exposure also directly impacts the activity of dopamine neurons in the VTA with potential alterations of eCB-mediated inhibition of VTA GABA neurons and glutamate terminals, resulting in a decrease of eCB-dependent disinhibition of dopamine neuron firing and dopamine release in the nucleus accumbens (Scherma et al., 2016), suggesting a broader impact of cannabis during adolescence on dopamine functions. The specific impact of adolescent THC exposure on mesocortical dopamine neurons or on dopamine release and signaling within the prefrontal cortex still needs to be investigated. Similarly, other drugs of abuse seem to have a critical influence on corticolimbic circuits and brain functions if they are used during adolescence compared to adulthood (for a complete view on the impact of drugs on adolescent brains see these recent books edited by Bell and Rahman, 2021a,b).
Impact of adolescent palatable food overconsumption on prefrontal circuits and functions
In parallel to cannabis use by teenagers, in recent decades there has been a dramatic rise of obesity amongst children and adolescents, due to the increased availability of energy-dense and highly palatable foods and drinks (Crews et al., 2007; Wang et al., 2008; Ogden et al., 2016). Moreover, animal studies have shown that adolescents are more sensitive to palatable foods such as high-fat and high-sugar foods (Wilmouth and Spear, 2009; Friemel et al., 2010; Marshall et al., 2017, 2020) which may increase food-seeking behaviors, lead to overconsumption, unbalanced dietary habits and obesity.
The dopamine system is well-known to respond directly to food rewards and modulate food-seeking behaviors by acting in prefrontal and subcortical regions (Hajnal and Norgren, 2001; Bassareo et al., 2002; Hajnal et al., 2004; Berridge, 2007; Avena et al., 2008; de Araujo et al., 2010; Kenny, 2011; McCutcheon, 2015; Alhadeff et al., 2019; Zimmerman and Knight, 2020; Grove et al., 2022). Similarly, eCBs are tightly linked to feeding as they are derived from poly-unsaturated fatty acids and are able to modulate homeostatic and non-homeostatic/hedonic feeding (Mahler et al., 2007; Maccarrone et al., 2010; Lau et al., 2017; Coccurello and Maccarrone, 2018). In humans and rodents, obesity in adults is associated with alteration of both dopamine and eCB circuits (Berthoud and Morrison, 2008; South and Huang, 2008; Volkow et al., 2011; Bello et al., 2012) but also with dysfunction of prefrontal functions (Reichelt, 2016; Lowe et al., 2019). In adolescents, the delayed development of both dopamine and eCB systems may simultaneously support this adolescent sensitivity to overnutrition, but also provides a vulnerability window for the long-term effects of unbalanced dietary habits.
The differential time course in the development of cortical and subcortical dopamine pathways may be responsible of increased reactivity to palatable foods during adolescence, leading to overconsumption and increased food-seeking responses (Wilmouth and Spear, 2009; Friemel et al., 2010; Marshall et al., 2017, 2020). As eCB signaling controls the activity of mesocorticolimbic circuits, increased levels of CB1 receptors during adolescence may also participate to this process by decreasing VTA GABAergic activity and decreasing cortical control on VTA and striatal neurons, all together leading to increased dopamine activity (Lau et al., 2017; Sallam and Borgland, 2021) and food-seeking behaviors (Mateo et al., 2017).
Several studies have also investigated the impact of adolescent exposure to palatable food on related brain functions to understand how vulnerable these circuits may be to natural rewards. Adolescent overnutrition causes complex behavioral alterations which seem to be highly dependent on diet parameters including but not limited the constitution of the diet (e.g. high fat, high sugar, cafeteria diet), the duration of exposure (age at start, length of time exposed, withdrawal period between diet and testing) or other exposure parameters (e.g., continuous or limited access, combined access with control diet or not). We focus here on reward- and prefrontal-related functions but there is also an important literature on the effect of these dietary habits on learning, memory and emotional behaviors (for recent reviews on the topic see Kendig, 2014; Tsan et al., 2021). Taken together, several studies indicate that exposure to highly palatable foods during adolescence, but not at adulthood, strongly impacts reward-related functions including the preference for palatable foods (Vendruscolo et al., 2010b; Carlin et al., 2016; Naneix et al., 2016; Rabasa et al., 2016; Gueye et al., 2018), conditioned place preference for food (Privitera et al., 2011), motivation for food rewards (Frazier et al., 2008; Vendruscolo et al., 2010a; Reichelt et al., 2016; Tantot et al., 2017; Wong et al., 2017; Naneix et al., 2018; Ducrocq et al., 2019), hedonic processing (Naneix et al., 2016; but see Steele et al., 2019), and sensitivity to drugs of abuse (Blanco-Gandía et al., 2017; Naneix et al., 2017). More importantly, several adolescent dietary habits also seem to impact prefrontal-related functions including control of goal-directed behavior (Tantot et al., 2017; but see Kendig et al., 2013), memory extinction (Baker and Reichelt, 2016), and cognitive control (Reichelt et al., 2015; Labouesse et al., 2017; Robertson and Rasmussen, 2017; Steele et al., 2019).
At the neurobiological level, exposure to highly palatable foods during adolescence is associated with broad anatomical and functional alterations of the dopamine system including reduced dopamine clearance in the striatum (Baladi et al., 2015), increased sensitivity of the mesolimbic pathway (Naneix et al., 2017) and changes in the expression of dopamine markers (Teegarden et al., 2009; Carlin et al., 2016; Naneix et al., 2017, 2018) in the prefrontal cortex and the nucleus accumbens. To our knowledge, the specific effects of such adolescent diets on prefrontal dopamine release, transmission and associated plasticity has not been investigated. However, the functioning of prefrontal microcuircuits is strongly impacted by adolescent consumption of palatable foods. As with cannabis exposure, prefrontal GABA signaling seems especially vulnerable, with diet-induced decreased of GABA levels (Sandoval-Salazar et al., 2016) and numbers of parvalbumin interneurons (Reichelt et al., 2015, 2019; Baker and Reichelt, 2016). Moreover, juvenile obesity in mice also impairs prefrontal glutamatergic transmission including NMDA-dependent synaptic plasticity and AMPA postsynaptic currents (Labouesse et al., 2017). Surprisingly, given its role in feeding and appetite, there are no clear data available on the impact of such diet exposure on the eCB system. In adult animals, obesity or the exposure to high-sugar/high-fat foods alters eCB-dependent cortical synaptic plasticity and insulin effects on VTA dopamine neurons to control ingestive behaviors (Labouèbe et al., 2013; Liu and Borgland, 2015; Liu et al., 2016; Lau et al., 2017). As maternal high-fat diet dysregulates the eCB system (Almeida et al., 2022; Urbonaite et al., 2022), we might predict high-fat / high-sugar diet exposure during adolescence would have similar effects. The exact nature of these alterations is not well-understood and the mechanisms which make adolescent PFC circuits particularly vulnerable are yet to be determined. However, altered dopamine and eCB signaling may both contribute to long-lasting diet-induced dysfunctions in executive functions.
Conclusion
Dopamine and eCB signaling are central elements in the regulation of prefrontal microcircuits and their dysregulation is associated with numerous neuropsychiatric disorders that typically first present in adolescence. During adolescence, prefrontal circuits undergo important developmental changes which support the emergence of adaptive adult behaviors. Dopamine and eCB prefrontal systems have a similar delayed maturation during adolescence characterized by transitory increases in receptors expression, gradual increases in neurotransmitter levels and important changes in synaptic effects. Given their interactions with different neuronal populations and effects at different synaptic sites, adolescent remodeling of these systems may play a key role in the successful maturation of prefrontal circuits and their functioning.
Despite a considerable increase in research on this topic during the last few decades, numerous questions remain. By increasing the recruitment of GABAergic interneurons and the sustained activity of pyramidal neurons during the transition to adulthood, prefrontal dopamine signaling increases the selection of specific inputs, decreasing the signal-to-noise ratio and refining prefrontal processing (O'Donnell, 2011; Caballero et al., 2016). Specific guidance cues control the late development of dopamine fibers (Hoops and Flores, 2017) but the mechanisms governing synaptic changes and the emergence of adult-like PFC activity compared to limbic regions remains unclear. Moreover, despite clear effects of external insults (drugs of abuse, palatable foods, and stress) during adolescence on prefrontal functions, anatomical organization of the mesocortical pathway and on the functioning of prefrontal glutamate and GABA transmission, the impact on the functioning of this dopamine pathway in vivo and its interaction with local microcircuits remains poorly explored compared to other dopamine circuits. One of the reasons for this may come from the unique properties of the mesocortical pathway (Sesack et al., 1998; Lammel et al., 2008) which have made it challenging to investigate in vivo until recently.
For the eCB system, most of our knowledge on the maturation of the eCB system comes from studying the effect of drugs including THC or CB1 agonists given during adolescence. The prefrontal eCB system presents important anatomical changes during adolescence (Rubino et al., 2015; Caballero et al., 2016). However, little is known about related neurophysiological changes on different prefrontal populations and the underlying processes governing these changes. Considering the important role of eCB in responses to food and in the control of feeding (Lau et al., 2017), there is also an important lack of information on the impact of unbalanced dietary habits during adolescence on eCB signaling.
Finally, a crucial point to consider is how dopamine and eCB systems interact through development. At adulthood they exhibit strong functional interactions to control diverse motivated behaviors. As they both exhibit a continued maturation throughout adolescence, which is not observed in other neuromodulatory systems, they may represent a crucial milestone in postnatal brain development in health and disease. The recent development of cutting-edge tools such as specific optical sensors for in vivo and ex vivo recordings (Labouesse et al., 2020; Dong et al., 2021) allows us to dissect microcircuits and use longitudinal studies to measure dynamic changes of prefrontal dopamine and eCB signaling from childhood to adulthood which until now were not possible.
Author contributions
All authors conceptualized, wrote and edited the manuscript, designed and produced all figures, and approved the submitted version.
Funding
FN was funded by the Royal Society (RGS_R1_211013), the Wellcome Trust Institutional Strategic Support Fund (RG13793-43), and the Tenovus Scotland (G21.11). KZP was funded by the Medical Research Council (project MR/T03260X/1) at the University of Sussex in the lab of Eisuke Koya.
Acknowledgments
KZP acknowledges the mentorship of Dr. Eisuke Koya in allowing her the time to contribute to this manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
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Keywords: prefrontal cortex (PFC), adolescence, dopamine, endocannabinoid, reward, neuromodulators
Citation: Peters KZ and Naneix F (2022) The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period. Front. Neural Circuits 16:939235. doi: 10.3389/fncir.2022.939235
Received: 08 May 2022; Accepted: 14 October 2022;
Published: 01 November 2022.
Edited by:
Cecilia Flores, McGill University, CanadaReviewed by:
Kuei Y. Tseng, University of Illinois at Chicago, United StatesKristen Delevich, Washington State University, United States
Lauren Mackenzie Reynolds, Centre National de la Recherche Scientifique (CNRS), France
Copyright © 2022 Peters and Naneix. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Fabien Naneix, ZmFiaWVuLm5hbmVpeCYjeDAwMDQwO2FiZG4uYWMudWs=