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REVIEW article

Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1464169
This article is part of the Research Topic New Insights into Intracellular Pathways and Therapeutic Targets in CNS Diseases View all 9 articles

The Role of Histone Deacetylases in Epilepsy：From lactate metabolism to protein lactylation

Provisionally accepted
Xi Kuang Xi Kuang 1Shuang Chen Shuang Chen 2Qingmei Ye Qingmei Ye 3*
  • 1 Hainan Health Vocational College, Haikou, Hainan Province, China
  • 2 Hubei Provincial Hospital of Integrated Chinese and Western Medicine, wuhan, China
  • 3 Hainan General Hospital, Haikou, China

The final, formatted version of the article will be published soon.

    Protein lactylation is a new form of protein post-translational modification that has been proposed recently. Lactoyl groups are mainly converted from the glycolytic product lactate, and protein lactylation in brain tissue has been shown to correlate with neuronal excitability. Ischemic stroke can enhance neuronal glycolysis to cause lactate accumulation in brain tissue. The lactate accumulation may increase neuronal excitability by upregulating protein lactylation levels, thereby inducing post-stroke epilepsy. Current clinical treatments for improving seizures have made significant progress, but about 30% of patients with epilepsy still cannot control their condition with medication, and the incidence of epilepsy is trending upward. In this paper, we have sorted out the mechanisms of epilepsy-associated neuronal death mediated by lactate metabolism and protein lactylation, and analyzed the possibility that histone deacetylase inhibitors can alleviate seizures by modulating protein lactylation, thus providing new ideas for future research on epilepsy pathogenesis and clinical treatment.

    Keywords: Protein lactylation, Histone deacetylase, Epilepsy, High-mobility group box 1, Hypoxia inducible factor-1α, Lactate

    Received: 13 Jul 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Kuang, Chen and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qingmei Ye, Hainan General Hospital, Haikou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.