This article is a correction to:
Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment
Jason Mares1†Ana Paula Costa2†William J. Dartora2Krista M. Wartchow2Artur Lazarian2David A. Bennett3Tal Nuriel4Vilas Menon1*
Laura Beth J. McIntire2,4*- 1Center for Translational & Computational Neuroimmunology, Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, United States
- 2Lipidomics and Biomarker Discovery Lab, Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, NY, United States
- 3Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States
- 4Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, United States
A corrigendum on
Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment
by Mares, J., Costa, A. P., Dartora, W. J., Wartchow, K. M., Lazarian, A., Bennett, D. A., Nuriel, T., Menon, V., and McIntire, L. B. J. (2024). Front. Aging Neurosci. 16:1419253. doi: 10.3389/fnagi.2024.1419253
In the published article, there was an error in the caption for Figure 5. Impact of lipid species in the dorsolateral prefrontal cortex and serum on cognition controlling for educational background and neuropathological markers as published. The caption text in Figure 5 was incorrectly stated as: (A) Multiple regression models for cognitive global random slope as the dependent variable are conducted for brain and (B) serum. Volcano plots present the main results of the regressions with lipid species coefficient and BH-adjusted p-values along the x and y axes, respectively. (C) Models are re-run accounting for amyloid plaques and tau tangles markers in brain and (D) serum.
The corrected caption appears below.
Figure 5. Impact of lipid species in the dorsolateral prefrontal cortex and serum on cognition controlling for educational background and neuropathological markers. (A) Education-adjusted scores for the blue eigen module are shown in diagnosis-genotype groups. (B) Association of the residuals of education-adjusted blue modules with cognitive global random slope are shown and post-hoc linear regression lines are added onto the plot. The left-top table reports correlation test results between residuals and cognitive global random slope for each diagnosis-genotype group. (C, D) Using linear models, we analyzed the association of the cognitive global random slope with each lipid species in the (C) DLPFC and (D) serum data. Volcano plots present the main results of these models with lipid species beta estimates and Benjamini-Hochberg-adjusted p-values shown along the x and y axes, respectively and significant results are shown above the threshold (dashed line).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: lipidomics, lipid metabolism, Alzheimer's disease, ROSMAP, ApoE
Citation: Mares J, Costa AP, Dartora WJ, Wartchow KM, Lazarian A, Bennett DA, Nuriel T, Menon V and McIntire LBJ (2024) Corrigendum: Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment. Front. Aging Neurosci. 16:1480818. doi: 10.3389/fnagi.2024.1480818
Received: 14 August 2024; Accepted: 27 August 2024;
Published: 25 September 2024.
Edited and reviewed by: Allison B. Reiss, New York University, United States
Copyright © 2024 Mares, Costa, Dartora, Wartchow, Lazarian, Bennett, Nuriel, Menon and McIntire. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Laura Beth J. McIntire, lbm7002@med.cornell.edu; Vilas Menon, vm2545@cumc.columbia.edu
†These authors have contributed equally to this work and share first authorship