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ORIGINAL RESEARCH article

Front. Aging Neurosci., 22 June 2023
Sec. Neurocognitive Aging and Behavior
This article is part of the Research Topic Panoramic View of Cognitive Impairment: Interdisciplinary Cognitive Research View all 19 articles

Threshold effects of the relationship between physical exercise and cognitive function in the short-sleep elder population

\r\nYanwei You,&#x;Yanwei You1,2†Yuquan Chen&#x;Yuquan Chen3†Xiangyu Chen,&#x;Xiangyu Chen1,2†Mengxian Wei,Mengxian Wei1,2Jiahui YinJiahui Yin4Qi Zhang*Qi Zhang5*Qiang Cao,*Qiang Cao6,7*
  • 1Division of Sports Science and Physical Education, Tsinghua University, Beijing, China
  • 2School of Social Sciences, Tsinghua University, Beijing, China
  • 3Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • 4College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
  • 5Undergraduate Department, Taishan University, Tai’an, China
  • 6Department of Earth Sciences, Kunming University of Science and Technology, Kunming, China
  • 7School of Pharmacy, Macau University of Science and Technology, Taipa, Macao SAR, China

Background: It has been demonstrated that elderly people’s cognitive capacities can be improved with exercise, and short sleep is linked to cognitive decline. However, the impact of physical exercise on cognitive performance in seniors who do not get enough sleep is largely unknown. This makes it an intriguing subject to explore further.

Methods: This study consisted of elders (over 60 years old) who participated throughout the National Health and Nutrition Examination Survey’s 2011–2014 cycle (NHANES). Weighted linear regression model and restricted cubic splines analysis were performed to evaluate the association between physical exercise and cognitive function. In the end, 1,615 samples were scrutinized and the total number of weighted respondents was 28,607,569.

Results: Results showed that in the Animal Fluency test and the Digit Symbol Substitution test, a positive association was found between physical exercise volume and scores in the fully adjusted model. A two-piecewise linear regression model was then applied to explore the threshold effect of exercise on cognitive performance. Before 960 and 800 MET-minutes/week, there were consistent positive relationship between exercise and scores of the Animal Fluency test [ß (95% CI): 0.233 (0.154, 0.312), p < 0.001] and Digit Symbol Substitution test [β (95% CI): 0.555 (0.332, 0.778), p < 0.001], respectively. However, there was a saturation effect where physical exercise volume reached the two inflection points.

Conclusion: According to our research, the benefit of exercise did not always expand with the exercise volume increment under the short-sleep condition, which challenged existing knowledge. The short-sleep elder group could maintain cognitive performance with no more than 800 MET-minutes/week of physical exercise. Verification of these findings requires further biological investigations.

GRAPHICAL ABSTRACT
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Graphical Abstract. Study design and main findings.

1. Introduction

Aging leads to cognitive decline such as progressive impairment in memory, judgment, language, and attention, among other cognitive domains (Morley, 2018). In United States, there was an increase in the prevalence of cognitive impairment among women from 18.7% in 1996 to 21.2% in 2014 and among men from 17.6% in 1996 to 21.0% in 2014 (Hale et al., 2020). It was determined from results analyzing 160 studies in a meta-analysis that dementia occurred at a pooled incidence of 17.2 per 1,000 person in a year in elder population aged 60 years or older (Fiest et al., 2016). A decline in cognitive abilities, especially cognitive impairments and their associated diseases, can have a profound effect on an individual, his or her family, and society in general (Wubker et al., 2015; Connors et al., 2019). Sleep factors, with unusual sleep patterns (i.e., short-sleep), poor sleep quality, and sleep disorder (e.g., insomnia) were associated with occurrence of cognitive impairment in the elderly.

In modern society, short-sleep in the elder population has become increasingly common. Sleeplessness and disturbed sleep appear to increase as people age, along with a decrease in good quality nocturnal sleep (Ohayon et al., 2004; Basner et al., 2007). In addition, plentiful evidence has shown that inadequate sleep had negative consequences on cognitive function (Hu et al., 2017; Xu et al., 2021; You et al., 2023c). One cross-sectional study using the UK Biobank data reported that short-sleep (<7 h) was associated with a significant decline in cognitive abilities in the elderly (Kyle et al., 2017). Over a 3-year follow-up, another population-based analysis of adults over 50 found that individuals who complained for sleep issues suffered accelerated cognitive deterioration than those who didn’t (Jelicic et al., 2002). Given the significant breadth and impact of insufficient sleep on cognition among elders, there was an urgent need to find effective and practical solutions to these problems.

Studies have found that regular exercise and physical activity was an effective strategy to mitigate the cognitive decline in the elder group (Espeland et al., 2017; Dominguez et al., 2021). Physical exercise can improve memory, focus, and concentration (Chirles et al., 2017), as well as reduce the risk of neurological diseases (Rolland et al., 2008), cardiovascular diseases (Fletcher et al., 2005), diabetes (Sampath Kumar et al., 2019), and osteoarthritis (You et al., 2021b), which were all common among senior citizens. Furthermore, regular exercise has been demonstrated to improve overall mental health (Deslandes et al., 2009; You et al., 2021c), reduce stress (Stubbs et al., 2017), and improve sleep disturbance (You et al., 2023a), which can all have a positive effect on cognitive function. Hence, regular exercise is a simple and effective way to maintain cognitive health, decrease the prevalence of certain diseases, and elevate living standards for elderly people.

However, the effects of physical exercise on cognition in the elderly were not consistent. An epidemiological study showed that neither global nor domain-specific cognitive function improved with moderate-intensity physical exercise programs after 24 months (Sink et al., 2015). Contrarily, a single exercise session had no impact on cognition and even raised perceptions of stress (Hopkins et al., 2012). It is possible that these inconsistent findings are due to different study designs and confounding factors, particularly when the impact of sleep on elderly people is considered. Elderly people’s cognitive abilities can be improved through exercise, while short sleep is associated with cognitive decline. To sum up, it is not only crucial but also interesting to explore the relationship between physical exercise and cognitive function under short-sleep conditions. Additionally, the evidence from large population-based studies is limited.

To the best of our knowledge, there was limited prior evidence that specifically examined whether physical exercise affected cognitive function in the community of elder groups with short-sleep conditions. In this study, by using a general sample from the National Health and Nutrition Examination Survey (NHANES), we aimed to: (1) examine the relationship between physical exercise and cognitive function in the short-sleep elder population; and (2) quantify its dose-response form and further assess the relationship by threshold analysis.

2. Materials and methods

2.1. Design and participants

Study data were from the National Health and Nutrition Examination Survey (NHANES), a comprehensive population-based survey intended to gather information about civilians in the United States (US). A multistage probability sampling design was applied to derive a typical selection of non-institutionalized households through the NHANES, which has been collected on approximately 10,000 people every two years since 1999. A research procedure of NHANES was approved by the Institutional Review Board (IRB) of the National Center for Health Statistics (NCHS), with written informed consent obtained.

Based on two cycles of “continuous NHANES” (2011/2012, 2013/2014), a total of 3,632 participants were initially included after excluding those less than 60 years old (n = 16,198). In addition, participants who slept less than 7 h were included in this study, leaving 2,126 samples for finally analysis. Subsequently, eligible participants needed to have complete data on cognitive tests. This resulted in an analytical sample of 1,833 survey participants. Finally, participants without covariates data were excluded from the analysis, leaving 1,615 samples for finally analysis (see Figure 1).

FIGURE 1
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Figure 1. Flowchart depicting the selection strategy.

2.2. Exposure measurement

Self-reported sleep length was collected on usual weekdays or workdays. In NHANES year cycle 2011–2014, participants were asked about their routine sleep hours: “How much sleep do you get (hours)?” Referring to previous literature (Su et al., 2021), short-sleep duration was defined as ≤7 h per night. The Physical Activity Questionnaire was used to gather data on the exposure variable, physical exercise, during home interviews. Physical exercise was defined as leisure time physical activity (including sports, fitness, and other recreational activities), as opposed to work-related physical activities (which included paid and unpaid jobs, household chores, and yard work).

The metabolic equivalent of task (MET) for the specified activity was multiplied by the participants’ reported weekly exercise time. To determine the MET-minutes per week, we used moderate and vigorous physical exercise (MVPE) measures. The Physical Activity Guidelines for Americans (PAGA) weighting mechanism was employed in the MVPE approach, where 2 min of moderate activity equated to 1 min of vigorous exercise (Ainsworth et al., 2000). Subsequently, the standard MET value of each activity was then multiplied by the overall amount of MVPE minutes per week to determine the MET-minutes per week. This method of quantifying physical exercise volume was also employed in earlier papers (You et al., 2022). Each level of exercise corresponded to a predetermined MET score, depending on whether reported as moderate (4 MET) or vigorous intensity (8 MET). Since the cumulative effects of a single exercise event may not be accurately reflected by a shift of 1 MET, exercise volume was described in terms of 100 MET as a unit of measurement (100*MET-min/week) in this study. In view of the fact that there was limited recommended physical activity guide for the elderly with short-sleep, the physical exercise volume was then categorized into three quantiles, none (<1 MET-min/week), low (from 1 to 360 MET-min/week), and moderate to vigorous (≥360 MET-min/week) for further analysis.

2.3. Cognitive function modules

The Animal Fluency test and the Digit Symbol Substitution test (DSST) were used to measure cognitive function in the NHANES. These assessments were conducted in a household interview or at a Mobile Examination Center (MEC). In the Animal Fluency test, which measured categorical verbal fluency and executive function, participants were instructed to name as many animals as they could in a minute. Processing speed, sustained attention, and working memory were evaluated using the Wechsler Adult Intelligence Scale (WAIS III) performance module called the DSST. This examination was administered using a paper form with a key located on top containing nine symbols and digits. A total of 133 symbols were displayed followed by numbers, and participants were asked to determine what each symbol represented in 2 min. Higher scores indicated greater cognitive function across all tests. The score was calculated as the total number of accurate matches. Detailed information about paradigm of the two cognitive tests was described in the Supplementary material.

2.4. Covariate assessment

Referring to the previous literature (Huang et al., 2021; You et al., 2023b), age, gender, race (non-Hispanic white, non-Hispanic black, Mexican American, and other races), marital status (never married, married or living with partner, widowed, divorced, or separated), family poverty income ratio [low income (<1), middle income (1,3), and high income (>3)], and educational attainment (below high school, high school, and college or above) were all extracted from the demographic questionnaire. Additionally, the questionnaires for smoking cigarettes and drinking alcohol were used to gather information about smoking status and alcohol intake status. According to the questionnaire replies, the status of alcohol use was divided into three categories: non-drinker, moderate alcohol use, and heavy alcohol use. Smoking status was classified as never, former, and current. Moreover, we evaluated the individuals’ chronic diseases (Wang et al., 2023). Participants were deemed to have diabetes mellitus (DM) if they met the following criteria: (1) A doctor has diagnosed you with diabetes; (2) HbA1c (%) > 6.5; (3) fasting glucose (mmol/l) ≥ 7.0; and (4) random blood glucose (mmol/l) ≥ 11.1; (5) 2-h OGTT Blood Glucose (mmol/l) ≥ 11.1; (6) use of insulin or diabetes drugs. Self-reported congestive heart failure, coronary heart disease, angina, heart attack, or stroke were attributed to cardiovascular disease (CVD). Detailed covariate information was available at http://www.cdc.gov/nchs/nhanes/.

2.5. Statistical analyses

To comply with the NHANES protocol, all data were combined into a single dataset and analyzed using the masked variance and weighting procedure. Using the weights from the Mobile Examination Center interviews, 4 years’ worth of survey data from NHANES 2011 to 2014 were combined to address non-response, non-coverage, and unequal probabilities of selection. This strategy was consistent with the weight method of prior researches (Shen et al., 2019; You et al., 2022). The merged weights were calculated as WT11–14 = (1/2) * WTMEC2YR11–12 + (1/2) * WTMEC2YR13–14, where WTMEC2YRs were variables from NHANES 2011–2014. In this study, we employed both multivariate adjusted and unadjusted models: Model 0 was adjusted for no covariates; Model 1 was adjusted for age, sex, race; Model 2 was adjusted for age, sex, race, marital status, education, poverty status, body mass index, smokers, alcohol drinkers, diabetes mellitus, and cardiovascular diseases.

Weighted linear regression model was used to investigate the association between physical exercise and test results for cognitive function. To explore the threshold impact and take into account any confounders, we constructed a model of two-piecewise linear regression. The threshold level of physical exercise (100 * MET-minutes/week) was determined using a recurrence method, which includes identifying the inflection point along a predefined interval and selecting the most likely inflection point. Using the log-likelihood ratio test, the two-piecewise linear regression model was compared to the one-line linear regression model. Simultaneously, the non-linear relationship was further evaluated using the restricted cubic spline (optimal knots = 3). Stratified analyses were conducted to explore the influence of covariates on the relationship between physical exercise and cognitive function. The R Foundation’s software1 was used for all statistical analyses, and a p value of 0.05 or less was regarded as statistically significant.

3. Results

In the final analysis, 1,615 participants aged 60 or older were included, and represented for a weighted population of 28,607,569. Table 1 displays the sociodemographic data of the study subjects. Study participants were an average of 68.79 years old, 47.17% of whom were male. The mean sleep length of all participants was 6.29 h per day. In addition, the average physical activity among total participants was 595 MET-minutes/week. For the cognitive function assessment, the mean score of the Animal Fluency test (reflecting verbal fluency and executive function) and the score of the Digit Symbol Substitution test (reflecting processing speed, sustained attention, and working memory) was 18.54 and 53.55, respectively.

TABLE 1
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Table 1. Demographic characteristics of study participants in NHANES.

Physical exercise and cognitive function test results were analyzed using a weighted linear regression model. As for the Animal Fluency test, when physical exercise was assessed as a continuous variable, Table 2 reveals that higher exercise volume was associated with better performance [Model 0, β (95% CI): 0.115 (0.085,0.144), p < 0.001; Model 1, β (95% CI): 0.099 (0.071, 0.128), p < 0.001; Model 2, β (95% CI): 0.077 (0.048, 0.106), p < 0.001]. Exercise was also associated with this outcome when assessed as a category variable. In the fully adjusted Model 2, taking the none exercise group as the reference, moderate to vigorous volume was positively associated with the Animal Fluency test scores [β (95% CI): 1.946 (1.126, 2.765), p < 0.001]. However, no significant association was identified in the low level physical exercise group. According to Supplementary Table 1, stratified analysis revealed that these associations were consistent across subgroups.

TABLE 2
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Table 2. Associations between physical exercise and cognitive function in the short-sleep elder population.

When it comes to the Digit Symbol Substitution test, similar findings are also identified in Table 2. Results showed that higher exercise volume was associated with higher scores of the Digit Symbol Substitution test when exercise volume was assessed as a continuous variable [Model 0, β (95% CI): 0.263 (0.152, 0.375), p < 0.001; Model 1, β (95% CI): 0.224 (0.119, 0.328), p < 0.001; Model 2, β (95% CI): 0.077 (0.048, 0.106), p = 0.038]. Also, this association persisted when exercise was assessed as a category variable. In the fully adjusted Model 2, using the reference group of those with no exercise, moderate to vigorous volume was positively associated with the Digit Symbol Substitution test performance [β (95% CI): 3.707 (1.325, 6.090), p = 0.006] in the Model 2. Additionally, a stratified analysis showed that these associations were consistent for subgroups with different demographic characteristics, as detailed in Supplementary Table 2.

An analysis of the log-likelihood ratio was performed to compare the one-line (non-segmented) model to the segmented regression model, and our results indicated a threshold existed. As for the Animal Fluency test (Table 3), based on a two-piecewise linear regression model, we calculated that the inflection point was 960 MET-minutes/week. As seen on the left side of the inflection point, the β (95% CI) and p-value were 0.233 (0.154, 0.312) and < 0.001, respectively. On the right side of the inflection point, we found no significant association between physical exercise and cognitive test’s score, with β (95% CI) and p-value of 0.013 (−0.027, 0.053) and 0.522. Similar results are also found in the Digit Symbol Substitution test (Table 4). The score of the test was positively correlated with physical exercise until it bottomed out at 800 MET-minutes/week [β (95% CI): 0.555 (0.332, 0.778), p < 0.001]. However, when the physical exercise volume was higher than 800, such association seemed to saturate [β (95% CI): −0.044 (−0.136, 0.048), p = 0.349]. In Figure 2, using restricted cubic splines, we flexibly modeled and visualized the relationship between cognitive performance and physical exercise volume among short-sleep elders. When exercise volume reached 9.6 and 8 (100*MET-minutes/week), there was a saturation effect where the effects of physical exercise on the Animal Fluency test and Digit Symbol Substitution test plateaued.

TABLE 3
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Table 3. Threshold effect analysis of the relationship between physical exercise and score of the Animal Fluency test in the short-sleep elders (based on Model 2).

TABLE 4
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Table 4. Threshold effect analysis of the relationship between physical exercise and score of the Digit Symbol Substitution test in the short-sleep elders (based on Model 2).

FIGURE 2
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Figure 2. The dose-response relationship between exercise volume with the score of the Animal Fluency test (A) and score of the Digit Symbol Substitution test (B) in the short-sleep elders.

4. Discussion

In this population-based study, physical exercise volume was found to be positively associated with the cognitive function in the short-sleep elders. Additionally, exercise and cognitive performance were found to be non-linearly correlated. The relationship was stated as follows: the scores of cognitive tests rose substantially with the expanded level of exercise, but reached a plateau after exercise volume at 960 MET-minutes/week for the Animal Fluency test and 800 MET-minutes/week for the Digit Symbol Substitution test. Our study detected that physical exercise had a threshold effect on cognitive function in short-sleep elders.

Our study identified a positive association between physical exercise volume and cognitive function in elderly individuals who get short amounts of sleep, which was consistent with a prior meta-analytic study in the aging population (Colcombe and Kramer, 2003; Lam et al., 2018). In several population studies (Spirduso and Clifford, 1978; Emery and Gatz, 1990), it was also verified that older high-fit individuals performed cognitive tests better than older low-fit individuals. While the mechanism of this association was not yet understood, it was clear that, in addition to improving cognitive function, exercise has been linked to increased expression of brain chemicals such as molecular mediators and growth factors represented by brain-derived neurotrophic factor (BDNF). Animal studies showed that exercise induces BDNF in the brain, most robustly in the hippocampal region (Cotman et al., 2007). Neuronal cells’ survival, differentiation, migration, dendritic arborization, synaptogenesis, and plasticity were all influenced by BDNF (Greenberg et al., 2009). This neurotrophin’s molecular mechanism has been explored in a recent study that FNDC5, which was previously identified as a muscle protein induced by exercise, was elevated in the brain and might lead to better cognitive ability (Wrann et al., 2013). There was also a study that explored these effects from the molecular perspective that the benefits of exercise were attributed to the control of communications between BDNF, p-CREB, and NMDAR signaling, which was closely related to the brain function of spatial learning and memory (Wu et al., 2020).

From the dose-response investigation of the relation between exercise and cognitive function in short-sleep elders was performed, our study found that there was a threshold effect of exercise in this special group. The 2018 Physical Activity Guidelines indicated that there was still much to learn regarding how much physical exercise is necessary to enhance cognitive abilities (Erickson et al., 2019), and there lacked strong evidence that whether physical activity was always effective in improving the cognition, especially in short-sleep aged adults. Physical exercise appeared to have a threshold effect (no more than 800 MET-minutes/week) on cognitive function in short-sleep elders, with an increase in cognitive function observed when exercise volume was kept within such a level (800 MET-minutes/week volume exercise was equal to perform 200-min moderate intensity exercise or 100-minutes vigorous intensity exercise per week). This was a novel finding, considering that WHO Guidelines 2020 recommended elders to exercise for 150–300 min each week at a moderate level (WHO, 2020).

Consistent with our results, researchers using cohort data from the China Health and Retirement Longitudinal Study also discovered that moderate and mild physical exercise was linked to higher cognitive functioning, as opposed to vigorous exercise (Wu et al., 2021). Obviously, sleep plays an important role in cognitive function and lacking sleep may induce disorders of brain hormones and chemicals during daily executive activities. Moderate level exercise has been proposed to activate the reticulum system’s arousal mechanism, thus improving various cognitive functions (Dietrich and Audiffren, 2011). Excessive exercise might, however, result in the prefrontal cortex being disengaged from higher-order functions due to greater activation of the premotor cortex and supplementary motor area. It was also found that vigorous exercise might be difficult for beginners and elders with concomitant diseases, and could lead to feelings of incompetence, failure, and low self-esteem (You et al., 2021a). Hence, exercise should be regulated, taking into account the individual’s sleep habits and duration, to ensure the most beneficial effect on cognitive function.

The strengths of this study included that we used the study samples from a nationwide population. To our awareness, this was the initial research to examine the dose-response relationship between physical exercise and cognitive function in the specific short-sleep aged population. Exercise volume and cognitive performance associations were analyzed using adjusted weighted regression in consideration of the complex multistage sampling design of NHANES. In addition, threshold analysis was performed in order to quantify the dose-response form of the association. We also used the stratified analysis to further verify these results in consideration of confounding factors, including sociodemographic characteristics, BMI, smoking and alcohol drinking status, as well as chronic diseases.

It was also important to note that this study had the following limitations. Firstly, due to the NHANES’ cross-sectional design, the causal or temporal relationship among these associations was still questionable in the elderly short-sleep population. There was also an assumption that elders with cognitive decline or impairment would unable to perform high volume of exercise activities. Secondly, in spite of the fact that we adjusted for possible confounders, residual confounding effects (i.e., biological and genetic factors) could still bias our results. Thirdly, the measurement of physical exercise was assessed by self-report questionnaires in NHANES design, which tended to be imprecise compared with objectively measured test such as the accelerometer (Barros et al., 2021). Moreover, the results of this study were only applicable to elderly people with short sleep, and additional research is needed in order to better understand sleep patterns and the effects of age. Lastly, it is unknown whether the pandemic or other public health emergencies will alter these associations. Research on the biological mechanisms of exercise and COVID-19 is therefore necessary to shed light on this population’s cognition (Gonzales et al., 2022).

5. Conclusion

Utilizing the NHANES data, we assessed short-sleep older adults’ physical exercise and cognitive function in this study. Physical exercise showed positive associations with performance on a test of Animal Fluency and a test of Digit Symbol Substitution. In addition, a dose-response-based analysis detected the threshold effect in the short-sleep elders, and performing no more than 800 MET-minutes/week exercise was positively associated with cognitive abilities. However, the underlying molecular mechanisms of such association remain unknown. Future research is needed to better understand the relationship between physical exercise and cognitive function in this population, as well as the potential mechanisms.

Data availability statement

Publicly available datasets were analyzed in this study. This data can be found here: https://wwwn.cdc.gov/nchs/nhanes/Default.aspx.

Author contributions

YY, YC, and XC designed the study and wrote the original draft manuscript. YY, YC, XC, MW, and JY reviewed and edited the revised version of manuscript, collected, analyzed, and interpreted the data. QZ and QC critically administrated, reviewed, and approved the manuscript. All authors read and approved the final manuscript.

Acknowledgments

The authors appreciate the time and effort given by participants during the data collection phase of the National Health and Nutrition Examination Survey (NHANES) project.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1214748/full#supplementary-material

Footnotes

  1. ^ http://www.R-project.org

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Keywords: cognitive function, physical exercise, short-sleep, elder population, NHANES, threshold effect

Citation: You Y, Chen Y, Chen X, Wei M, Yin J, Zhang Q and Cao Q (2023) Threshold effects of the relationship between physical exercise and cognitive function in the short-sleep elder population. Front. Aging Neurosci. 15:1214748. doi: 10.3389/fnagi.2023.1214748

Received: 30 April 2023; Accepted: 05 June 2023;
Published: 22 June 2023.

Edited by:

Song Ge, University of Houston–Downtown, United States

Reviewed by:

Chao Yang, University of Texas MD Anderson Cancer Center, United States
Peijin Han, University of Michigan, United States

Copyright © 2023 You, Chen, Chen, Wei, Yin, Zhang and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Qi Zhang, 3334858663@qq.com; Qiang Cao, 2918292861@qq.com

These authors have contributed equally to this work

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