Corrigendum: The impact of non-coding RNAs in the epithelial to mesenchymal transition

A Corrigendum on
The impact of non-coding RNAs in the epithelial to mesenchymal transition

by Hussen BM, Shoorei H, Mohaqiq M, Dinger ME, Hidayat HJ, Taheri M and Ghafouri-Fard S (2021). Front. Mol. Biosci. 8:665199. doi: 10.3389/fmolb.2021.665199

In the published article, the References column was incorrect in Supplementary Table 1. The table has been updated in the original article supplementary material.

In the published article, Supplementary Table 2 was mistakenly not included in the publication. The table has been added to the original article supplementary material.

After publication of this article, it has come to the authors’ attention that the following referenced articles have been retracted. These references have been removed from the original article.

Chong L., Lingling S., Jiaying S. (2019). Circular RNA hsa_circ_0000467 modulates SGK1 to facilitate cell migration, metastasis, and EMT while repressing apoptosis in colorectal cancer by sponging miR-383-5p. RSC Adv. 9 39294–39303. 10.1039/c9ra07900a.

Fan H., Liu X., Zheng W. W., Zhuang Z. H., Wang C. D. (2017). MiR-150 alleviates EMT and cell invasion of colorectal cancer through targeting Gli1. Eur. Rev. Med. Pharmacol. Sci. 21 4853–4859.

Jin D., Guo J., Wu Y., Du J., Wang X., An J., et al. (2019). UBE2C, directly targeted by miR-548e-5p, increases the cellular growth and invasive abilities of cancer cells interacting with the EMT marker protein zinc finger E-box binding homeobox 1/2 in NSCLC. Theranostics 9 2036–2055. 10.7150/thno.32738.

Li R., Liu J., Qi J. (2020a). Knockdown of long non-coding RNA CCAT1 suppresses proliferation and EMT of human cervical cancer cell lines by down-regulating Runx2. Exp. Mol. Pathol. 113:104380. 10.1016/j.yexmp.2020.104380.

Li X., Wang S.-W., Xi-Ling L., Yu F.-Y., Cong H.-M. (2020c). Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA-15a and repressing ROCK1 expression. Inflamm. Res. 69 897–910. 10.1007/s00011-020-01364-8.

Li Z.-T., Zhang X., Wang D.-W., Xu J., Kou K.-J., Wang Z.-W., et al. (2020d). Overexpressed lncRNA GATA6-AS1 inhibits LNM and EMT via FZD4 through the Wnt/β-catenin signaling pathway in GC. Mol. Ther. Nucleic Acids 19 827–840. 10.1016/j.omtn.2019.09.034.

Lin X., Wang S., Sun M., Zhang C., Wei C., Yang C., et al. (2019). miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization. J. Hematol. Oncol. 12:20.

Liu S., Song L., Yao H., Zhang L., Xu D., Gao F., et al. (2016). MiR-375 is epigenetically downregulated by HPV-16 E6 mediated DNMT1 upregulation and modulates EMT of cervical cancer cells by suppressing lncRNA MALAT1. PLoS One 11:e0163460.

Liu W., Yang Y. J., An Q. (2020). LINC00963 promotes ovarian cancer proliferation, migration and EMT via the miR-378g/CHI3L1 Axis. Cancer Manag. Res. 12 463–473. 10.2147/cmar.s229083.

Sun J., Hu J., Wang G., Yang Z., Zhao C., Zhang X., et al. (2018). LncRNA TUG1 promoted KIAA1199 expression via miR-600 to accelerate cell metastasis and epithelial-mesenchymal transition in colorectal cancer. J. Exp. Clin. Cancer Res. 37:106.

Wang Z., Wang J., Wang K., Zhou Y., Wang J. (2020). LncRNA FEZF1-AS1 promoted chemoresistance, autophagy and epithelial-mesenchymal transition (EMT) through regulation of miR-25-3p/ITGB8 axis in prostate cancer. Eur. Rev. Med. Pharmacol. Sci. 24 2281–2293.

Wu K., Li L., Li L., Wang D. (2020). Long non-coding RNA HAL suppresses the migration and invasion of serous ovarian cancer by inhibiting EMT signaling pathway. Biosci. Rep. 40:BSR20194496.

Xu W., Sun X., Zang C., Jiang Y. (2020). lncRNA SNHG7 promotes tumorigenesis of nasopharyngeal carcinoma via epithelial-to-mesenchymal transition. Oncol. Lett. 19 2721–2726.

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Zhou X., Men X., Zhao R., Han J., Fan Z., Wang Y., et al. (2018). miR-200c inhibits TGF-beta-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer. Cancer Gene Ther. 25 68–76. 10.1038/s41417-017-0005-y.

A correction has been made to Introduction, miRNAs in EMT, Paragraph 1. This sentence previously stated:

“In this type of cancer, miR-145-5p, miR-383-5p, miR-3622a-3p, miR-205 and miR-200b inhibit EMT process through targeting CDCA3, SGK1, SALL4, MDM4 and HIF-1α, respectively (Shang et al., 2017; Chong et al., 2019; Chang et al., 2020; Chen et al., 2020; Fan and Wang, 2020).”

The corrected sentence appears below:

“In colorectal cancer, miR-145-5p, miR-3622a-3p, miR-205 and miR-200b inhibit EMT through targeting CDCA3, SALL4, MDM4 and HIF-1α, respectively (Shang et al., 2017; Chang et al., 2020; Chen et al., 2020a; Fan and Wang 2020).”

A correction has been made to Introduction, lncRNAs in EMT, Paragraph 1. The section previously included the following sentences:

“CCAT1 is an oncogenic lncRNA in cervical cancer cells whose silencing has blocked proliferation, migratory potential, invasiveness and EMT process in these cells. CCAT1 silencing has led to downregulation of Runx2 and suppression of PI3K/AKT signaling in cervical cancer cells PI3K/AKT signal (Li et al., 2020a). HAL is a downregulated lncRNA in serous ovarian cancer tissues and cells. Upregulation of HAL has suppressed invasive potential of these cells and enhanced their apoptosis. HAL has been shown to directly suppress expression of TWIST1. Functional studies has highlighted the role of HAL in regulation of EMT (Wu K. et al., 2020). In ovarian cancer, LINC00963, TC0101441, CCAT1 and PTAR promote EMT through modulation of miR-378g, KiSS1, miR-490-3p and miR-101-3p, respectively (Liang et al., 2018; Mu et al., 2018; Liu et al., 2020; Qiu et al., 2020).”

The corrected sentence appears below:

“In ovarian cancer, TC0101441, CCAT1 and PTAR promote EMT through modulation of KiSS1, miR-490-3p and miR-101-3p, respectively (Liang et al., 2018; Mu et al., 2018; Qiu et al., 2020).”

A correction has been made to Introduction, lncRNAs in EMT, Paragraph 2. This sentence previously stated:

“Over-expression of LINC00963, FLVCR1-AS1 and LINC00261 has been associated with poor overall survival rate of patients with neoplasm (Yan et al., 2019; Gao et al., 2020; Liu et al., 2020).”

The corrected sentence appears below:

“Over-expression of FLVCR1-AS1 and LINC00261 has been associated with poor overall survival rate of patients with neoplasm (Yan et al., 2019; Gao et al., 2020).”

In the published article, there was an error in Tables 1, 2 as published. These tables cited four retracted articles that should be removed (Lin et al., 2019; Jin et al., 2019; Liu et al., 2020; Sun et al., 2018). The corrected Tables 1, 2 and their captions appear below.

Table 1

Table 1. Prognostic roles of EMT-associated miRNAs in cancer (ACT: adjacent control tissue).

Table 2

Table 2. Diagnostic and prognostic role of EMT-associated lncRNAs in cancer (ACTs: adjacent control tissues, OS: overall survival).

The authors apologize for these errors and state that these do not change the scientific conclusions of the article in any way. The original article has been updated.

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