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SYSTEMATIC REVIEW article

Front. Microbiol.
Sec. Infectious Agents and Disease
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1414330
This article is part of the Research Topic Fighting Antimicrobial Resistance in Developing Countries: Innovative Approaches and Challenges View all 9 articles

The frequency of mutations in the penA, mtrR, gyrA and parC genes of Neisseria gonorrhoeae, the presence of tetM gene and antibiotic resistance/susceptibility: a systematic review and meta-analyses

Provisionally accepted
Ana Clara Mendes Ana Clara Mendes 1Renan Pedra de Souza Renan Pedra de Souza 1Diana Bahia Diana Bahia 1,2*
  • 1 Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Mato Grosso, Brazil
  • 2 Federal University of Minas Gerais, Belo Horizonte, Brazil

The final, formatted version of the article will be published soon.

    Gonorrhoea is currently one of the most important sexually transmitted infections (STIs) due to the increasing spread of multidrug-resistant strains of Neisseria gonorrhoeae. The aim of this study was to analyze the association between resistance or decreased susceptibility to antibiotics in N. gonorrhoeae and the presence of mutations in the penA, mtrR, tetM, gyrA and parC genes. We conducted a systematic review according to the PRISMA guidelines. We selected 19 studies for the penA gene, 23 for gyrA and parC, 18 for mtrR and 12 for tetM using the Science Direct and PubMed databases. Meta-analyses of isolates resistant to penicillin, cefixime and ceftriaxone showed that more than 50% of isolates had mutations in the penA and mtrR genes. More than 50% of azithromycin-resistant isolates had mutations in the mtrR gene, while more than 50% of ciprofloxacinresistant and intermediate-resistant isolates had mutations in gyrA. Less than 50% of the isolates with intermediate resistance to ciprofloxacin had mutations in parC. The plasmid containing the tetM gene was found in more than 50% of tetracycline-resistant isolates. Infection surveillance and genetic studies are important for controlling the spread of gonorrhoea, which can improve the quality of life of infected people and reduce the financial burden on public health systems.

    Keywords: Neisseria gonorrhoeae, antibiotic resistance, Mutation, penA, MTRR, tetM, gyrA, ParC gene

    Received: 08 Apr 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Mendes, Souza and Bahia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Diana Bahia, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.