This article is a correction to:
Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
Greg Hussack1†
Martin A. Rossotti1†
Henk van Faassen1Tomohiko Murase2
Luiz Eugenio2Joseph D. Schrag3Kenneth K.-S. Ng2,4*
Jamshid Tanha1,5*- 1Life Sciences Division, Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, ON, Canada
- 2Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
- 3Life Sciences Division, Human Health Therapeutics Research Centre, National Research Council Canada, Montréal, QC, Canada
- 4Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada
- 5Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
A corrigendum on
Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
by Hussack, G., Rossotti, M. A., van Faassen, H., Murase, T., Eugenio, L., Schrag, J. D., Ng, K. K.-S., and Tanha, J. (2023). Front. Microbiol. 14:1110541. doi: 10.3389/fmicb.2023.1110541
In the published article, there was an error. In the Title, the genus name “Clostridioides” was misspelled as “Clostridiodes.”
This sentence previously stated:
“Structure-guided design of a potent Clostridiodes difficile toxin A inhibitor”
The corrected sentence appears below:
“Structure-guided design of a potent Clostridioides difficile toxin A inhibitor”
A correction has been made to the Abstract section, first sentence. This sentence previously stated:
“Crystal structures of camelid heavy-chain antibody variable domains (VHHs) bound to fragments of the combined repetitive oligopeptides domain of Clostridiodes difficile toxin A (TcdA) reveal that the C-terminus of VHH A20 was located 30 Å away from the N-terminus of VHH A26.”
The corrected sentence appears below:
“Crystal structures of camelid heavy-chain antibody variable domains (VHHs) bound to fragments of the combined repetitive oligopeptides domain of Clostridioides difficile toxin A (TcdA) reveal that the C-terminus of VHH A20 was located 30 Å away from the N-terminus of VHH A26.”
A correction has been made to the Keywords section. This keyword previously stated:
“Clostridiodes difficile”
The corrected keyword appears below:
“Clostridioides difficile”
A correction has been made to the Introduction section, first paragraph. This sentence previously stated:
“Clostridiodes difficile is a spore-forming Gram-positive bacterium capable of infecting humans and causing symptoms ranging from mild diarrhea to pseudomembranous colitis”
The corrected sentence appears below:
“Clostridioides difficile is a spore-forming Gram-positive bacterium capable of infecting humans and causing symptoms ranging from mild diarrhea to pseudomembranous colitis”
A correction has been made to the Abbreviations section, page 2 Footnote. This abbreviation previously stated:
“TcdA, Clostridiodes difficile toxin A”
The corrected abbreviation appears below:
“TcdA, Clostridioides difficile toxin A”
A correction has been made to the Abbreviations section, page 2 Footnote. This Abbreviation previously stated:
“TcdB, Clostridiodes difficile toxin B”
The corrected abbreviation appears below:
“TcdB, Clostridioides difficile toxin B”
A correction has been made to the Figure 1 legend, first sentence. This sentence previously stated:
“Model of the A20-A26 fusion protein bound to the CROPs domain of Clostridiodes difficile TcdA.”
The corrected sentence appears below:
“Model of the A20-A26 fusion protein bound to the CROPs domain of Clostridioides difficile TcdA.”
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: biparatopic, Clostridioides difficile, inhibitor, nanobody, single-domain antibody, toxin, VHH
Citation: Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK-S and Tanha J (2023) Corrigendum: Structure-guided design of a potent Clostridioides difficile toxin A inhibitor. Front. Microbiol. 14:1167817. doi: 10.3389/fmicb.2023.1167817
Received: 16 February 2023; Accepted: 20 March 2023;
Published: 30 March 2023.
Approved by:
Frontiers Editorial Office, Frontiers Media SA, SwitzerlandCopyright © 2023 Hussack, Rossotti, van Faassen, Murase, Eugenio, Schrag, Ng and Tanha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Kenneth K.-S. Ng, a2VubmV0aC5uZyYjeDAwMDQwO3V3aW5kc29yLmNh; Jamshid Tanha, amFtc2hpZC50YW5oYSYjeDAwMDQwO25yYy1jbnJjLmdjLmNh
†These authors have contributed equally to this work and share first authorship