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CORRECTION article
Front. Microbiol. , 09 November 2021
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 12 - 2021 | https://doi.org/10.3389/fmicb.2021.795790
This article is a correction to:
Genetic and Phenotypic Characterization of the Novel Metallo-β-Lactamase NDM-29 From Escherichia coli
A Corrigendum on
Genetic and Phenotypic Characterization of the Novel Metallo-β-Lactamase NDM-29 From Escherichia coli
by Zhu, Y., Jia, X., Jia, P., Li, X., and Yang, Q. (2021). Front. Microbiol. 12:743981. doi: 10.3389/fmicb.2021.743981
In the original article, Starkova et al. (2021) was not cited in the article. The citation has now been inserted in Introduction, paragraph 2 and Discussion, paragraph 3.
Additionally, there was an error. Our article is the first research on NDM-29 in China rather than in Asia. Corrections have been made to Highlights, paragraph 1; Introduction, paragraph 2; Discussion, paragraph 1; Discussion, paragraph 3; and Discussion, paragraph 4.
The corrected paragraphs appear below.
Highlights, paragraph 1:
“- The first detailed report of the carbapenemase NDM-29 from E. coli and its genetic environment in China.
- A whole genome sequence analysis of the newly found plasmid pNC225-NDM-29 and the gene blaNDM−29.
- Complete functional verification experiments, including conjugation, transformation, cloning, and fitness cost.”
Introduction, paragraph 2:
“In a recent study, we discovered an NDM-29 carbapenemase- producing E. coli strain (19NC225), isolated from a patient's bile in 2019. The gene sequence of blaNDM−29 from a Klebsiella pneumoniae strain has been submitted to the NCBI database (NCBI), by researchers from Saint Petersburg, Russia (Starkova et al., 2021). Our study is the first detailed report of NDM-29 from E. coli in China, including genetic and phenotypic characterization, and confirms the potential threat of this new NDM-type carbapenemase to be a cause of extensively drug-resistant organism spread.”
Discussion, paragraph 1:
“Here we described a newly found carbapenemase, NDM-29, isolated from a clinical strain of E. coli. The success of conjugation from clinical isolation to E. coli EC600, K. pneumoniae ATCC 13883, and K. pneumoniae ATCC 700603 indicated the transferability of pNC225-NDM-29. The presence of the ISKpn19-based transposon where the region harboring blaNDM−29 is located suggested the risk of the spread of resistance caused by NDM-29. Meanwhile, no fitness cost was observed in the transconjugants/transformants containing plasmid pNC225-NDM-29, which demonstrated a limited burden from the transferable plasmid. However, the conjugation from donor to recipients (ATCC 13883, ATCC 700603, and DH5α) showed low efficiency, which may be due to high energy cost or multibarrier in recipients (Llosa et al., 2002). Although the growth curves did not show a significant impact of transferred plasmid on recipients, a limitation of growth curve that the competitive fitness of donor over recipients was not estimated and needs further study (Hanafi et al., 2016). Anyhow, the dissemination and adaptability of the NDM-29-harboring plasmid among clinical bacteria would be a threat to infectious control.”
Discussion, paragraph 3:
“Currently, the mutation of D130G has been reported in NDM- 14, and kinetic analysis indicated that NDM-14 has greater carbapenem resistance with a higher affinity for imipenem and meropenem (Zou et al., 2015). Based on our research, there is no difference between NDM-1 and NDM-29 in terms of susceptibility to carbapenems, which is in accordance with the findings of Starkova et al. (2021).”
Discussion, paragraph 4:
“In conclusion, we report the identification of a novel class B enzyme with carbapenemase activity, NDM-29, in a clinical E. coli isolate. The novel blaNDM−29 is first detected in China and was obtained from a MDR E. coli strain isolated from bile of a patient with biliary tract infection. The strain, containing two plasmids (pNC225-TEM1B and pNC225-NDM-29), belongs to ST1485 and O83:H42, showed homology with E. coli MS6198 from Australian (Hancock et al., 2017), which harbors blaNDM−1. The plasmid, pNC225-NDM-29, which encods blaNDM−29, exhibited 99% identity with six blaNDM−1-carrying plasmids, especially a IncN1 plasmid pNDM-BTR from an E. coli in urine specimen (99.96% identity and 100% coverage), and showed responsibility for the MDR phenotype.”
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: carbapenemase, NDM, Escherichia coli, whole-genome sequence, antimicrobial resistance
Citation: Zhu Y, Jia X, Jia P, Li X and Yang Q (2021) Corrigendum: Genetic and Phenotypic Characterization of the Novel Metallo-β-Lactamase NDM-29 From Escherichia coli. Front. Microbiol. 12:795790. doi: 10.3389/fmicb.2021.795790
Received: 15 October 2021; Accepted: 18 October 2021;
Published: 09 November 2021.
Approved by:
Frontiers Editorial Office, Frontiers Media SA, SwitzerlandCopyright © 2021 Zhu, Jia, Jia, Li and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Qiwen Yang, eWFuZ3Fpd2VuODFAdmlwLjE2My5jb20=
†These authors have contributed equally to this work
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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