Skip to main content

REVIEW article

Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1536547
This article is part of the Research Topic Tuberculosis: Recent Updates in Basic Research, Drug Discovery and Treatment View all 4 articles

Progress in the role of Nanoparticles in the diagnosis and treatment of bone and joint tuberculosis

Provisionally accepted
Yitong Ding Yitong Ding 1*Baiyun Li Baiyun Li 2*Yangfei Yi Yangfei Yi 1*Can Liu Can Liu 1*Jie Wen Jie Wen 3*Xiaohong Jian Xiaohong Jian 1*Yufei Li Yufei Li 1*
  • 1 College of Medicine, Hunan Normal University, Changsha, Hunan Province, China
  • 2 Hunan Normal University, Changsha, Hunan Province, China
  • 3 Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, China

The final, formatted version of the article will be published soon.

    Bone and joint tuberculosis (BJTB), caused by Mycobacterium tuberculosis (MTB), is a prevalent form of extrapulmonary tuberculosis that poses significant challenges to global public health due to difficulties in early diagnosis, prolonged treatment cycles, and drug resistance. Recent advancements in nanotechnology have introduced novel solutions for the early detection and precise treatment of BJTB, leveraging unique physicochemical properties such as high specific surface area, targeted delivery capabilities, sustained drug release, and excellent biocompatibility.In diagnostic applications, nanomaterials markedly enhance the sensitivity and accuracy of detection methods while reducing testing time. These technologies are adaptable to resourcelimited settings, enabling earlier patient intervention and mitigating disease progression risk. In therapeutic applications, nanomaterials prolong drug retention in bone tissue through targeted delivery, thereby decreasing medication frequency and minimizing toxic side effects, which significantly improves treatment efficacy. Despite substantial progress, further research is required to address long-term safety concerns, broaden clinical applicability, and evaluate performance under complex pathological conditions. This review summarizes recent advancements in nanomaterials for diagnosing and treating BJTB and identifies key areas for future research, laying the groundwork for advancing precision medicine and personalized treatments.

    Keywords: bone and joint tuberculosis, nanomaterials, diagnosis, Treatment, Tuberculosis

    Received: 29 Nov 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Ding, Li, Yi, Liu, Wen, Jian and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yitong Ding, College of Medicine, Hunan Normal University, Changsha, 410013, Hunan Province, China
    Baiyun Li, Hunan Normal University, Changsha, 410081, Hunan Province, China
    Yangfei Yi, College of Medicine, Hunan Normal University, Changsha, 410013, Hunan Province, China
    Can Liu, College of Medicine, Hunan Normal University, Changsha, 410013, Hunan Province, China
    Jie Wen, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, China
    Xiaohong Jian, College of Medicine, Hunan Normal University, Changsha, 410013, Hunan Province, China
    Yufei Li, College of Medicine, Hunan Normal University, Changsha, 410013, Hunan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.