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SYSTEMATIC REVIEW article

Front. Med.
Sec. Nuclear Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1517805
This article is part of the Research Topic Advances in PET-CT Imaging View all 13 articles

[18F]FDG PET/CT versus [18F]FDG PET/MRI in Staging of Non-Small Cell Lung Cancer: A Head-to-head Comparative Meta-Analysis

Provisionally accepted
Dandan Yu Dandan Yu Chaolin Chen Chaolin Chen *
  • Traditional Chinese Medical Hospital of Zhuji, Shaoxing, China

The final, formatted version of the article will be published soon.

    Purpose: This meta-analysis aims to compare the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in patients with non-small cell lung cancer(NSCLC). Methods: An extensive literature search was conducted throughout the PubMed, Embase, and Web of Science databases for works accessible through September 2024. We included studies assessed the diagnostic efficacy of [18F]FDG PET/CT and [18F]FDG PET/MRI in NSCLC. Results: The meta-analysis includes six studies with a total of 437 patients. The sensitivity and specificity of [18F]FDG PET/CT and [18F]FDG PET/MRI for detecting lymph node metastasis were similar, at 0.82 (0.68-0.94) vs. 0.86 (0.70-0.97) and 0.88 (0.76-0.96) vs. 0.90 (0.85-0.94), respectively, with no significant differences (P = 0.70 for sensitivity, P = 0.75 for specificity). For distant metastasis, the sensitivity of [18F]FDG PET/CT and [18F]FDG PET/MRI was 0.86 (0.60-1.00) and 0.93 (0.63-1.00), and specificity was 0.89 (0.65-1.00) vs. 0.90 (0.64-1.00), respectively, also showing no significant differences (P = 0.66 for sensitivity, P = 0.97 for specificity). Conclusions: Our meta-analysis shows that [18F]FDG PET/MRI has similar sensitivity and specificity to [18F]FDG PET/CT in identifying lymph node and distant metastases in patients with NSCLC. Additional larger sample prospective studies are needed to confirm these findings.

    Keywords: [ 18 F]FDG PET/CT, [ 18 F]FDG PET/MRI, Non-small cell lung cancer, Meta-analaysis, staging

    Received: 27 Oct 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Yu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chaolin Chen, Traditional Chinese Medical Hospital of Zhuji, Shaoxing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.